Hycanthone from MedChemExpress

Description

Hycanthone is a thioxanthenone DNA intercalator and inhibits RNA synthesis as well as the DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits apurinic endonuclease-1 (APE1) by direct protein binding with a K_D of 10 nM. Hycanthone is a bioactive metabolite of Lucanthone (HY-B2098) and has anti-schistosomal agent

Product Specs
ItemHycanthone
CompanyMedChemExpress
Price $66.00Supplier Page View Company Product Page
Catalog NumberHY-B1099
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.97%
TypeChemical
Molecular Weight356.48
FormulaC₂₀H₂₄N₂O₂S
Research AreaInfection

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(1) Hycanthone Inhibits Inflammasome Activation and Neuroinflammation-Induced Depression-Like Behaviors in MiceBiomolecules & TherapeuticsMarch 1, 2023Kyung-Jun Boo, Edson Luck Gonzales, Chilly Gay Remonde, Jae Young Seong, Se Jin Jeon, Yeong-Min Park, Byung-Joo Ham, Chan Young ShinPM). All procedures were approved by Konkuk IACUC, Seoul, Korea (KU20195). Drugs Hycanthone (Cat No. HY-B1099) was purchased from MedChemExpress (NJ, USA) and LPS (Cat No. L2630) was obtained from Sigma-Aldrich

(2) Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein bindingPloS oneJanuary 1, 2011Naidu MD, Agarwal R, Pena LA, Cunha L, Mezei M, Shen M, Wilson DM 3rd, Liu Y, Sanchez Z, Chaudhary P, et al.

(3) Effect of hycanthone administered in vivo upon the incorporation of radioactive precursors into macromolecules of Schistosoma mansoniMolecular and biochemical parasitologyJune 1, 1983Pica Mattoccia L, Cioli D.

(4) Action of antischistosomal drugs, hycanthone and its analog 1A-4 N-oxide, on viral interferon inductionJournal of toxicology and environmental healthJuly 1, 1980Hahon N, Ong T.

(5) [The regional blood flow of brainstem and effect of anti-vertigo drugs (author's transl)]Nihon Jibiinkoka Gakkai kaihoDecember 20, 1975Sano M, Matsunaga T.

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Hycanthone from MedChemExpress

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Hycanthone from MedChemExpress

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