D-AP5 from MedChemExpress

Product Specs
ItemD-AP5
CompanyMedChemExpress
Price $82.00Supplier Page View Company Product Page
Catalog NumberHY-100714A
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.94%
FormulaC5H12NO5P
Research AreaNeurological Disease
TypeChemical
Molecular Weight197.13
Quantity10 mM * 1 mL
Molecule NameD-AP5

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(1) Protocol for the generation of human medullary spinal trigeminal nucleus-like organoids and trigeminothalamic assembloidsSTAR ProtocJuly 14, 2026Wei Pang, Jinkui Zhu, Siyuan Chu, Yangfei XiangC9368 Muscimol,MCE,Cat# HY-N2313 (R)-Baclofen,MCE,Cat# HY-17354 Bicuculline,MCE,Cat# HY-N0219 D-AP5,MCE,Cat# HY-100714A CNQX disodium salt,Tocris,Cat# 1045 α-CGRP (human),MCE,Cat# HY-P1071 Cal-520,AAT Bioquest,Cat# 21130 Powerload,Invitrogen,Cat#

(2) Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and PlasticityAdvanced ScienceMay 29, 2026Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wenneurons were treated for 4 h with 1 µM TTX (Shanghai Charm‐Analysis, 20–309500), 50 µM D‐AP5 (MCE, HY‐100714A), and 100 µM DNQX (Abcam, ab120018) [61]. Neurons were then fixed and immunostained with anti‐GFP antibody

(3) FOXG1 Hierarchically Shapes Synaptic Functions in Striatal iSPNs and Contributes to ASD EtiologyNeuroscience BulletinFebruary 2, 2026Baoshen Zhang, Daxiang Xu, Shuangshuang Dong, Pei Zhu, Pengfei Jiang, Jie Sun, Junhua Liu, Huanxin Chen, Chunjie ZhaoMonmouth Junction, NJ, USA), and 50 μmol/L N-methyl-D-aspartate (NMDA) receptor blocker D-AP5 (MCE, HY-100714A). To assess the AMPAR/NMDAR ratio, both AMPAR- and NMDAR-mediated evoked excitatory postsynaptic currents

(4) Repetitive transcranial magnetic stimulation alleviates neuropathic pain via microglial polarization by modulating the METTL3/NMDAR2B/NLRP3 pathwayFrontiers in ImmunologyJanuary 26, 2026Jiayi Zhu, Lei Li, Rongnan Shi, Fei Xing, Yue Yang, Zhangyu Xu, Qin Wang, Qi Deng, Dan Li, Maomao Huang, et al.MedChemExpress; STM2457; T9060; Targetmol) and NMDAR2B (d-Serine; HY-100808; MedChemExpress; D-AP5; HY-100714A; MedChemExpress) were added to the culture medium, and their effects were verified. BV2 cells were pretreated

(5) SNX6-mediated subunit-specific secretory trafficking of AMPA receptors regulates synaptic function and plasticityCommun BiolDecember 22, 2025Jiaqi Zhai, Deng Pan, Chao-Hua Jiang, Jiang Chen, Dou Wang, Ranran Mao, Zhenzhen Guo, Huali Geng, Jiawei Nie, Lei Chen, et al.AMPAR-eEPSC values from 0 mV to 40 mV and from -70mV to 0 mV in the presence of 50 μM D-AP5(D-APV, HY-100714A, MedChemExpress, NJ, USA) to block NMDARs, and 10 μM Bicuculline (505875, Sigma-Aldrich) to block GABAA

(6) Chromatin remodeling factor BAF155 coordinates oligodendroglial-neuronal communications linked to regional myelination and autism-like behavioral deficits in miceNature CommunicationsDecember 21, 2025Xiaorui Wang, Cong Zeng, Zhonghao Wu, Minmin Lu, Xiao Wang, Yun Xiu, Qi Wang, Shouyu Wang, Xiaoying Chen, Yan Shen, et al.AMPA receptor antagonist NBQX (10 µM; MCE, HY-15068) and NMDA receptor antagonist D-AP5 (50 µM; MCE, HY-100714A) or TTX (1 µM) + NBQX (10 µM) + D-AP5 (50 µM) into the ACSF throughout the recording. We clamped membrane

(7) Social memory engram formation impairment in neuroligin-3 R451C knock-in mice is caused by disrupted prefrontal NMDA receptor-dependent potentiationCommunications BiologySeptember 30, 2025Zhiyuan Li, Qun Yang, Huiyi Li, Jiali Ge, Hangtian Yan, Jiahui Li, Yuzhen Fu, Kexian Yan, Sien Li, Jialin Chen, et al.induction compared with those during the 2–5 min baseline. In some experiments, 50 μM D-AP5 (MCE, China, HY-100714A) were added to the bath solution to block NMDARs and prevent LTP induction. For whole-cell LTD recordings,

(8) Suppressive effect of the anesthetic propofol on the T cell function and T cell-dependent immune responsesScientific reportsAugust 20, 2024Yamamoto W, Hamada T, Suzuki J, Matsuoka Y, Omori-Miyake M, Kuwahara M, Matsumoto A, Nomura S, Konishi A, Yorozuya T, et al.Tokyo, Japan). DL-2-amino-5-phosphonopentanoic acid (D-AP5) was purchased from MedChemExpress (Cat #HY-100714A; Monmouth Junction, NJ, USA). For in vivo experiments, we use Propofol Intravenous Injection 1% "Maruishi"

(9) Single-cell RNA sequencing reveals the immune features and viral tropism in the central nervous system of mice infected with Japanese encephalitis virusJ NeuroinflammationMarch 26, 2024Ling'en Yang, Junyao Xiong, Yixin Liu, Yinguang Liu, Xugang Wang, Youhui Si, Bibo Zhu, Huanchun Chen, Shengbo Cao, Jing YeInhibitor buffer”, which consists of CCS with 10 μM NBQX (Apexbio, B6566) and 50 μM APV (MedChemExpress, HY-100714A). Brain slabs, approximately 300 μm thick, were cut using a Leica VT 1200S vibratome. Slabs containing

(10) N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learningThe European journal of neuroscienceMarch 1, 2013Morris RG, Steele RJ, Bell JE, Martin SJ.

(11) The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitroThe Journal of neuroscience : the official journal of the Society for NeuroscienceJanuary 1, 1992Davis S, Butcher SP, Morris RG.

(12) The effects of a series of omega-phosphonic alpha-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparationsBritish journal of pharmacologyJanuary 1, 1982Evans RH, Francis AA, Jones AW, Smith DA, Watkins JC.

(13) [Histochemical localization of mucopolysaccharides in Nauphoeta cinerea (Blattoidea)]Rivista di istochimica, normale e patologicaJanuary 1, 1975Mosconi Bernardini P.

(14) Assessing the Nature of Human Brain-Derived Extracellular Vesicles on Synaptic Activity Via the Development of an Air-liquid Microfluidic Platform"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"January 1, 0001"Bernou C, Iwasaki Y, Lutz W, Almeida G, Béchard E, Delalande F, Rompais M, Bouget J, Gorda B, Cazevieille C, et al."(CNQX; Sigma–Aldrich, #C127‐5MG), and 50 µm (2R)‐amino‐5‐phosphonovaleric acid (AP5; MedChemExpress, # HY‐100714A) for 10 min prior to recording. Spikes were detected using a 10‐ms rolling window detecting values above

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D-AP5 from MedChemExpress

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