Acetaminophen from MedChemExpress

Product Specs
ItemAcetaminophen
CompanyMedChemExpress
Price $50.00Supplier Page View Company Product Page
Catalog NumberHY-66005
Quantity500 mg
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.98%
TypeChemical
Molecular Weight151.16
Molecule NameAcetaminophen
FormulaC8H9NO2
Research AreaInflammation/Immunology; Cancer

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(1) A commensal protozoan exacerbates acetaminophen-induced liver injury by producing free sphingosineGut MicrobesDecember 31, 2026Xiaoqing Yan, Yusi Shen, Qian Sun, Xiuwen Zhu, Qiuchong Chen, Longxiang Liao, Yuan Zhou, Wanpeng Cheng, Zhen Shi, Zhuanzhuan Liu, et al.(6 to 8 weeks old) were purchased from Vital River Laboratory Animal Technology. For the AILI, APAP (HY-66005, MCE) was intraperitoneally administered at a dose of 500 mg/kg (for acute liver injury) or 700 mg/kg

(2) Silibinin promotes hepatocyte proliferation through PINK1/Parkin-mediated mitophagy to alleviate acetaminophen-induced liver injuryClin Exp MedJuly 3, 2026Fengming Xu, Mohamed Albadry, Olaf Dirsch, Uta DahmenMedChemExpress and Procell system. E.g., Silibinin (Sigma-Aldrich, #S0417), Acetaminophen (MedChemExpress, #HY-66005), 3-Methyladenine (MedChemExpress, #HY-19312), and FBS (Procell system, #164210). Cell counting kit-8

(3) Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity TestingAdvanced ScienceJune 29, 2026Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, et al.troglitazone (10–50 µm; MedChemExpress, Cat# HY‐50935) or acetaminophen (APAP, 10–50 mm; MedChemExpress, Cat# HY‐66005) at the indicated concentrations. Stock solutions were prepared in DMSO and diluted in culture medium

(4) Hepatic SNHG9 links gut microbiota to liver protection in drug-induced liver injuryNat CommunMay 20, 2026Wu Bao, Bingqing Hang, Danyi Zeng, Jiajie Mao, Li-Bin Pan, Lichao Wang, Guangyi Xu, Meng Wang, Kailin Liu, Xianjiong Chen, et al.treatment Mice were given ad libitum access to food and water, then administered 500 mg/kg acetaminophen (CAT#HY-66005; MCE) dissolved in PBS via oral gavage. The mice were monitored for signs of distress throughout the

(5) Identification and validation of key PANoptosis-related genes via integrative machine learning and single-cell sequencing in AILIiScienceApril 17, 2026Shuo Li, Chenhui He, Meng Wang, Binli Ran, Guanghui Li, Guangzhong Dong, Heng Zhang, Chaopeng Mei, Yaodong Song, Qiwen Yu, et al.and reagent","Chemicals, peptides, recombinant proteins and reagent" ,, Acetaminophen,MCE,CAS No.: HY-66005 TRIzol,Invitrogen,Cat No.15596018 HI Script III RT SuperMix,Vazyme,Cat No. R323-01 SYBR Green PCR

(6) Bazedoxifene rescues hepatocytes from chemically induced oxidative ferroptotic injury in vivo and in vitro by inhibiting protein disulfide isomeraseiScienceMarch 20, 2026Xiangyu Hao, Tian-Hao Xiao, Yi-Chen Jia, Bao Ting Zhuproteins" ,, Bazedoxifene,MedChemExpress,Cat#HY-A0031; CAS: 198481-32-2 Acetaminophen,MedChemExpress,Cat#HY-66005; CAS: 103-90-2 Erastin,Selleck Chemicals,Cat#S7242; CAS:571203-78-6 RSL3,Selleck Chemicals,Cat#S8155;

(7) Gallium‐Doped MXene Nanozymes Protect Liver Through Multi‐Death Pathway Blockade and Hepatocyte RegenerationAdvanced ScienceJanuary 5, 2026Xiaopeng Cai, Jingwen Deng, Liqing Wang, Junjie Su, Dongyi Xian, Yilang Yan, Xinyu Yang, Chuanbin Wu, Tingting Peng, Yuan Ding, et al.h of attachment, the cells were subjected to oxidative stress by treatment with 10 mmol L−1 APAP (#HY‐66005, MCE, USA) for 24 h. Then, the cells were treated with V2C, Ga‐V2C, or NAC (25 µg mL−1) for addtional

(8) Downregulation of PCYT2 by increased portal pressure safeguards liver regeneration after partial hepatectomyTheranosticsJanuary 1, 2026Guangyin Pu, Yayue Song, Qiushi Li, Jinjie Duan, Guangyan Wang, Wenjing Xiu, Jingwen Xu, Xiaoyu Zhao, Wenhui Dong, Tingting Lan, et al.(containing 25 μg meclizine) at 17 h and 6 h before they were intraperitoneal injected with APAP (300 mg/kg; HY-66005, MedChemExpress, NJ) for 24 h. Due to variations in the meclizine content across different NP batches,

(9) ATG16L1 Regulates Reparative Function of Peritoneal Macrophages During Acute Drug-induced Liver InjuryCellular and Molecular Gastroenterology and HepatologyNovember 4, 2025Xun Wang, Xinyu Zhan, Yiyun Gao, Hao Wang, Zheng Liu, Mu Liu, Ling Lu, Haoming ZhouAdoptive Transfer of PMs At time = 0 hours, WT recipients received APAP (300 mg/kg, intraperitoneal, HY-66005, MCE) freshly dissolved in warm phosphate-buffered saline (PBS); control mice received equal-volume

(10) Lipin3 deficiency promotes hepatocyte ferroptosis and pyroptosis via activating JAK1-STAT3 pathway during acetaminophen induced acute liver injuryMol BiomedOctober 10, 2025Yu-Xing Liu, Qian Wang, Zi-Yu Xiangyang, Jie-Yi Long, Hao Huang, Liang-Liang FanELISA detection kit (LZ-E031454) was purchased from Shanghai Rayzbio Biotechnology Co., Ltd. APAP (HY-66005) was purchased from MedChemExpress. Erastin (KM9100), AS-252424 (KM7417) and CPT (KM15658) were purchased

(11) Kummerowia striata extract protects paracetamol-induced liver injury by modulating the S1P/Nrf2/Keap1 pathwayPLoS OneAugust 14, 2025Huanghui Qin, Runxiao Chen, Youlan Xie, Hang Liu, Yubo Xiao, Lanyu Lidissolved in distilled water for use. Acetaminophen (purity 99%, AR) was purchased from MCE (Catalog No. HY-66005) and freshly prepared for each experiment. It was dissolved by heating in a 70°C water bath for 10 minutes

(12) A combined “eat me/don’t eat me” strategy based on exosome for acute liver injury treatmentCell Reports MedicineApril 15, 2025Wei Du, Chen Chen, YingYing Liu, Huiyi Quan, Ming Xu, JingJing Liu, Ping Song, ZhiQiang Fang, ZhenSheng Yue, Hao Xu, et al.6 p.m. to 9 p.m. in dark room and then fasted from 9 p.m. to 9 a.m. next day. 300 mg/kg APAP (MCE, HY-66005) was intraperitoneal (i.p.) injected, and food were given back. Meanwhile, mice were randomly divided

(13) Mogroside V protects against acetaminophen-induced liver injury by reducing reactive oxygen species and c-jun-N-terminal kinase activation in miceWorld Journal of HepatologyMarch 27, 2025Jia-Lin Shi, Tian Sun, Qing Li, Chun-Mei Li, Jun-Fei Jin, Chong ZhangBiotechnology Co., Ltd. (Chengdu, China). The APAP powder (purity > 99.98%) was obtained from MCE Co., Ltd (HY-66005, China). The alpha mouse liver 12 (AML12) cells were cultivated in DMEM/F-12 medium enriched with 5%

(14) Chenodeoxycholic acid modulates cholestatic niche through FXR/Myc/P-selectin axis in liver endothelial cellsNat CommunMarch 1, 2025Peng Zhang, Xinying Li, Jinyuan Liang, Yuanwen Zheng, Yao Tong, Jing Shen, Yatai Chen, Penghu Han, Shuzheng Chu, Ruirui Liu, et al.were fasted overnight (17:00—9:00, 16 h) to reduce hepatic glutathione (GSH) levels before APAP (Cat#HY-66005, MCE) treatment. During fasting pretreatment, mice were housed in cages with wire mesh floors to prevent

(15) MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injuryCell DiscovFebruary 18, 2025Ru Xing, Ruilong Liu, Yongxiao Man, Chen Liu, Yajuan Zhang, Hong Gao, Weiwei Yang3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine (DDC) (137030) was purchased from Sigma-Aldrich. Acetaminophen (HY-66005) and Cycloheximide (HY-12320) were bought from MCE. Sirius rosa BB (S8060) was bought from Solarbio.

(16) Methylcobalamin protects against liver failure via engaging gasdermin ENature communicationsJanuary 31, 2025Xu W, Wang Y, Cui S, Zheng Q, Lin Y, Cui Q, Xie Y, Zeng Y, Zhang C, Li Y, et al.(HY-14520), dimethyl fumarate (HY-17363), Z-DEVD-FMK (HY-12466), cisplatin (HY-17394), acetaminophen (HY-66005), N-acetylcysteine (HY-B0215) were purchased from MCE (NJ, USA). Deoxycholic acid (D2510), cycloheximide

(17) Akkermansia muciniphila Mediated the Preventive Effect of Disulfiram on Acute Liver Injury via PI3K/Akt PathwayMicrob BiotechnolJanuary 18, 2025Ruonan Zhang, Xuewei Sun, Han Lu, Xinrui Zhang, Mingyan Zhang, Xuewen Ji, Xinyi Yu, Chengliang Tang, Zihan Wu, Yinghua Mao, et al.DSF APAP model mice were given intraperitoneal injection of 500 mg/kg APAP (500 mg/kg, MedChemExpress, HY‐66005, Shanghai, China). In the DSF treatment experiment, 500 mg/kg APAP was injected intraperitoneally for

(18) Thonningianin A ameliorates acetaminophen-induced liver injury by activating GPX4 and modulating endoplasmic reticulum stressFrontiers in pharmacologyJanuary 1, 2025Lai S, Ye Y, Ding Q, Hu X, Fu A, Wu L, Cao W, Liu Q, Dou X, Qi X.purchased from Shanghai Yuanye Biotechnology Co., Ltd. (Shanghai, China). Acetaminophen (APAP, Cat. No: HY-66005) was purchased from MedChemExpress (State of New Jersey, United States). Sodium carboxymethyl cellulose

(19) FAK inhibition delays liver repair after acetaminophen-induced acute liver injury by suppressing hepatocyte proliferation and macrophage recruitmentHepatology CommunicationsNovember 1, 2024Qing Li, Qi Xu, Jialin Shi, Wei Dong, Junfei Jin, Chong Zhanghours, male mice 6 to 7 weeks of age were intraperitoneally injected with 300 mg/kg of APAP (MCE, Cat. #HY-66005) to induce the ALI model. In parallel, the mice injected with equivolumetric saline solution were used

(20) FAK inhibition delays liver repair after acetaminophen-induced acute liver injury by suppressing hepatocyte proliferation and macrophage recruitmentHepatol CommunOctober 17, 2024Qing Li, Qi Xu, Jialin Shi, Wei Dong, Junfei Jin, Chong Zhanghours, male mice 6 to 7 weeks of age were intraperitoneally injected with 300 mg/kg of APAP (MCE, Cat. #HY-66005) to induce the ALI model. In parallel, the mice injected with equivolumetric saline solution were used

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Acetaminophen from MedChemExpress

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