IOX1 from MedChemExpress

Product Specs
ItemIOX1
CompanyMedChemExpress
Price $85.00Supplier Page View Company Product Page
Catalog NumberHY-12304
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.89%
TypeChemical
Molecular Weight189.17
FormulaC₁₀H₇NO₃
Research AreaCancer

Add to Compare List

MedChemExpress

1 Deer Park Drive, Suite F

MONMOUTH JUNCTION, NJ 08852

United States

Phone: US Tel: 609-228-6898
US Fax: 609-228-5909
EU Tel: +4686500910

Email: sales@medchemexpress.com
eu.sales@MedChemExpress.com

Company Profile

Website: medchemexpress.com

(1) DREAMS illuminates spatial DNA and RNA modification landscapesNature Cell BiologyAugust 24, 2026Yan Peng, Liang Xue, Yujie Zhang, Shuangshuang Feng, Yiting Lu, Houyu Zhang, Mingjie Dong, Chenyang Wang, Meng Bao, Waleed Alam, et al.and 1 mM TCEP. Where indicated, the established TET1 inhibitor OX1 (final concentration 10 μM; MCE, HY-12304) was added to the reaction buffer to assess TET1 enzyme activity67,68. In parallel, reactions were also

(2) KDM3A drives NSCLC proliferation and metastasis via H3K9 demethylation, EMT activation, and MMP-9 upregulationBiomolecules and BiomedicineNovember 3, 2025Bingqing Shi, Zhe Wang, Lei Xiu, Luyao Li, Xiaolian Yang, Guanhua Wang, Jianjun Li, Hu Wang, Yuning Han(Gibco, 10378016, CA, USA). The histone demethylase inhibitor IOX1 was obtained from Medchemexpress (Cat# HY-12304). CBA-1 was sourced from ProbeChem (Cat# PC-20353), and cisplatin was acquired from Medchemexpress (Cat#

(3) Improving the Efficiency of CRISPR/Cas9-Mediated Non-Homologous End Joining Gene Knockout Using Small Molecules in Porcine CellsBiomoleculesAugust 6, 2025Shihao Lv, Xiaokang Xu, Sijia Yang, Mingjie Feng, Zhongyu Yuan, Xueqing Liu, Chaoqian Jiang, Jun Song, Yanshuang Mu(Houston, TX, USA); Repsox (CAS number: HY-13012), GSK-J4 (CAS number: HY-15648B), and IOX 1 (CAS number: HY-12304) were obtained from the MedChemExpress company (Monmouth Junction, NJ, USA). These small molecules were

(4) Moxibustion regulates KDM4D expression and modulates lipid metabolism to inhibit tumor proliferation in CAC miceCancer Cell IntMay 5, 2025Guona Li, Jindan Ma, Luyi Wu, Hanxiao Zhang, Yaying Lin, Hongxiao Xu, Muen Gu, Kunshan Li, Hongsheng Dong, Yan Huang, et al.KDM4D [19]. The mice in the 5-c-8HQ group received intraperitoneal injections of 5-c-8HQ (10 mg/kg, HY-12304, MCE) once daily for 30 d [10]. Mice in the normal and CAC groups underwent the same grasping and fixation

(5) KDM3A Ablation Activates Endogenous Retrovirus Expression to Stimulate Antitumor Immunity in Gastric CancerAdvanced ScienceOctober 1, 2024Jiabin Zheng, Huolun Feng, Jiatong Lin, Jianlong Zhou, Zhihui Xi, Yucheng Zhang, Fa Ling, Yongfeng Liu, Junjiang Wang, Tieying Hou, et al.BGC823, 2 µg mL−1). Antibodies and Inhibitors KDM3A inhibitors used include IOX1 (MedChemExpress, cat. HY‐12304) and BIX01294 (MedChemExpress, cat. HY‐10587). The following antibodies were used: anti‐β‐tubulin (Arigo,

(6) Hypoxia triggers cardiomyocyte apoptosis via regulating the m6A methylation-mediated LncMIAT/miR-708-5p/p53 axisHeliyonJune 15, 2024Chuqiao Shen, Xiaoqi Chen, Yixuan Lin, Yan Yangwhereas mice in the MI + IOX1 group were intragastrically administered the ALKBH5 inhibitor IOX1 (cat no. HY-12304; MedChemExpress), at a dose of 20 mg/kg/day for 12 days [32,33]. After 24 h ligation, all the mice were

(7) TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammationProceedings of the National Academy of Sciences of the United States of AmericaFebruary 15, 2022Liu D, Zhao Z, She Y, Zhang L, Chen X, Ma L, Cui J.(T9284-500ML) were purchased from Sigma. Recombinant TNF-α (300-01A) was purchased from PeproTech. IOX1 (HY-12304) was purchased from MCE. LSB (50 mM Hepes, 150 mM NaCl, 1 mM EDTA, 10% glycerol, 1.5 mM MgCl2, and 1%

(8) Histone demethylase JMJD2D promotes the self-renewal of liver cancer stem-like cells by enhancing EpCAM and Sox9 expressionThe Journal of biological chemistryJanuary 1, 2021Deng Y, Li M, Zhuo M, Guo P, Chen Q, Mo P, Li W, Yu C.1:1000); HA-tag antibody (Thermo Fisher Scientific, Cat# 26183, 1:1000). The JMJD2D inhibitor 5-c-8HQ (HY-12304) was purchased from MCE. Lipofectamine 2000 (Cat #11668019) was purchased from Invitrogen. Cell culture Human

(9) A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5Journal of biomolecular screeningMarch 1, 2016Li F, Kennedy S, Hajian T, Gibson E, Seitova A, Xu C, Arrowsmith CH, Vedadi M.

(10) IOX1, a JMJD2A inhibitor, suppresses the proliferation and migration of vascular smooth muscle cells induced by angiotensin II by regulating the expression of cell cycle-related proteinsInternational journal of molecular medicineJanuary 1, 2016Hu Q, Chen J, Zhang J, Xu C, Yang S, Jiang H.

(11) A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1ChemMedChemMarch 1, 2014Schiller R, Scozzafava G, Tumber A, Wickens JR, Bush JT, Rai G, Lejeune C, Choi H, Yeh TL, Chan MC, et al.

(12) [Maternal and child health care among refugees in Sudan]LakartidningenMay 30, 1979Dahlin K.

(13) Histone H3K36me2 demethylase KDM2A promotes bladder cancer progression through epigenetically silencing RARRES3Cell death & diseaseJanuary 1, 0001"Lu B, Wei J, Zhou H, Chen J, Li Y, Ye L, Zhao W, Wu S."measured at 0, 12, 24, 36, 48, 60, and 72 h, respectively. Assessing drug synergism IOX1 (Cat. No. HY-12304) and all-trans-Retinoic acid (ATRA, Cat. No. HY-14649) were purchased from MedChemExpress (MCE). To

Be the First to Write a Review!

Description

MedChemExpress

Citations (13)

Reviews

IOX1 from MedChemExpress

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map