ISO-1 from MedChemExpress

Product Specs
ItemISO-1
CompanyMedChemExpress
Price $88.00Supplier Page View Company Product Page
Catalog NumberHY-16692
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.94%
TypeChemical
Molecular Weight235.24
FormulaC₁₂H₁₃NO₄
Research AreaInflammation/Immunology

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(1) Cardiac tertiary immune niches drive immune activation in immune checkpoint inhibitor myocarditisSci AdvAugust 28, 2026Carly C. Tymm, Matthieu Paiola, Shoiab Bukhari, Xizi Hu, Robert Winchester, Adam MorHepes, and 50 μM β-mercaptoethanol. Small-molecule inhibitors ISO-1 (MIF inhibitor; MedChemExpress, HY-16692), bindarit (CCL2/7/8 inhibitor; MedChemExpress, HY-B0498), and maraviroc (CCR5 inhibitor; MedChemExpress,

(2) Characterizing the SASP-Dependent Paracrine Spreading of Senescence Between Human Brain Cell TypesAging CellAugust 15, 2026Taylor Russo, Markus RiesslandTreatment Treatment with migration inhibitor factor (MIF) antagonist ISO‐1 (MedChemExpress, Catalog No. HY‐16692) (Kok et al. 2018) was utilized to prevent MIF‐associated communication between senescence inducers

(3) Pancancer Fine-Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung AdenocarcinomaAdvanced science (Weinheim, Baden-Wurttemberg, Germany)May 1, 2026Wang T, Zhao H, Sun X, Ding Y, Zhu Z, Yu X, Zhu R, Wang D, Li K, Liu Y, et al.experiment, mice bearing established LLC tumors were randomized to receive either the MIF inhibitor ISO‐1 (HY‐16692, MedChemExpress, 35 mg/kg/day, administered via intraperitoneal injection) or PBS (5/group) for a duration

(4) comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disordersCell stem cellMarch 5, 2026Shen Y, Benlabiod C, Watson E, Gurashi K, Fower A, Rodriguez-Romera A, Reyat JS, Adnan-Awad S, Hargreaves R, Kemble S, et al.2-phosphate,Sigma,Cat#49752-10G Penicillin-Streptomycin,Gibco,Cat#15140122 GlutaMAX,Gibco,Cat#35050061 ISO-1,MedChemExpress,Cat#HY-16692 Bortezomib,MedChemExpress,Cat#HY-10227 CellTrace Violet Cell Proliferation Kit,ThermoFisher Scientific,Cat#C34557 DAPI,Life Technologies

(5) Epithelial redox stress programs macrophage immunometabolism through a ZNF24-MIF–NF–κB pathway in chronic nonbacterial prostatitisRedox BiologyMarch 1, 2026Fei Zhang, Andong Zhang, Tong Meng, Xianhong Liu, Cheng Yang, Chaozhao Liang, Meng Zhangtreated daily for 14 days with ISO-1 (3.5 mg/kg in 10 % dimethyl sulfoxide (DMSO)/90 % corn oil; Cat. No. HY-16692; MCE) [31] via intraperitoneal injection, whereas the controls received vehicle alone. In parallel,

(6) Characterizing the SASP-Dependent Paracrine Spreading of Senescence Between Human Brain Cell TypesbioRxivFebruary 14, 2026Taylor Russo, Markus Riesslandtreatment Treatment with migration inhibitor factor (MIF) antagonist ISO-1 (MedChemExpress, Catalog No. HY-16692) (31) was utilized to prevent MIF-associated communication between senescence inducers and receiving

(7) MIF Regulates the Th17/Treg Ratio to Exacerbate Kidney Injury in Chronic Kidney DiseaseInflammationDecember 23, 2025Ruijing Zhang, Keyi Fan, Heng Wang, Jinshan Chen, Chuanlong Lu, Lizheng Li, Runze Chang, Maolin Qiao, Yuhang Zhang, Hongjiu Zhang, et al.10.0.7 (BD Biosciences). Besides, MIF protein (MedChemExpress, HY-P7387) and ISO-1 (MedChemExpress, HY-16692) were added to CD4 + T cells. Statistical Analysis The data are presented as the means ± SDs. Normality

(8) MIF downregulation attenuates neuroinflammation via TLR4/MyD88/TRAF6/NF-κB pathway to protect dopaminergic neurons in Parkinson’s disease modelCommunications BiologyNovember 18, 2025Yicong Huang, Chang Zhou, Shaogang Qutreatment MIF inhibitor, (S, R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester (ISO-1, HY-16692) and Resatorvid (Toll-like receptor 4 inhibitor, HY-11109) were purchased from MedChemExpress. MN9D

(9) Metformin protects against cyclophosphamide-induced ovarian fibrosis by MIF/CD74-mediated macrophage polarizationJournal of Translational MedicineNovember 12, 2025Ping Nie, Bo Yao, Zhejun Zhang, Jingling Li, Minghua Wang, Gendie E. Lash, Bihui Guo, Ping Lisupplemented with 10% fetal bovine serum (Gibco, USA) (5% CO2, 20% O2, 37 °C). The MIF antagonist, ISO-1 (HY-16692, MedChemExpress, New Jersey, USA) and the 4HC chemotherapy reagent (19527, Cayman, USA) were also used

(10) Macrophage migration inhibitory factor (MIF) suppresses mitophagy through disturbing the protein interaction of PINK1-Parkin in sepsis-associated acute kidney injuryCell Death & DiseaseJuly 2, 2024Tianlong Li, Jiachen Qu, Chang Hu, Jingjing Pang, Yaoyao Qian, Yiming Li, Zhiyong PengμM, MedChemExpress, HY-100941), OLA (2 μM, MedChemExpress, HY-10162), ISO-1 (20 μM, MedChemExpress, HY-16692), and T0467 (5 μM, MedChemExpress, HY-139308), were individually co-incubated with HK-2 cells [17, 28–31].

(11) Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammationImmunityOctober 10, 2023Pekayvaz K, Gold C, Hoseinpour P, Engel A, Martinez-Navarro A, Eivers L, Coletti R, Joppich M, Dionísio F, Kaiser R, et al.Jurkat cells were added to the corresponding wells after 72h of incubation with MIF inhibitor 1600 μM (ISO-1 HY-16692, MedChemExpress ®) or DMSO only. Cells were incubated for 60 min prior to image acquisition. The resulting

(12) Human embryonic stem cells secrete macrophage migration inhibitory factor: A novel findingPloS oneJanuary 1, 2023Wei Y, Zheng X, Huang T, Zhong Y, Sun S, Wei X, Liu Q, Wang T, Zhao Z.control group, MIF (NBp2-35005, NOVUS, USA) group, CXCL12 (Ab259416, Abcam, U.K) group, and ISO-1 (HY-16692, MCE, USA) group. MIF group was divided into 30 ng/mL group, 100 ng/mL group, and 300 ng/mL group. CXCL12

(13) Exosomal MIF Derived From Nasopharyngeal Carcinoma Promotes Metastasis by Repressing Ferroptosis of MacrophagesFrontiers in cell and developmental biologyJanuary 1, 2021Chen W, Zuo F, Zhang K, Xia T, Lei W, Zhang Z, Bao L, You Y.and Western blotting. Processing and Culture of Macrophages Macrophages were co-cultured with ISO-1(HY-16692,20uM, MCE) and human recombinant MIF factor (300–69,20 ng/ml, PeproTech) for 24 h. Ferrostatin-1 (Fer-1)

(14) Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced diseaseJournal of endometriosisSeptember 30, 2011Nothnick WB, Colvin A, Cheng KF, Al-Abed Y.

(15) ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsisThe Journal of biological chemistryNovember 4, 2005Al-Abed Y, Dabideen D, Aljabari B, Valster A, Messmer D, Ochani M, Tanovic M, Ochani K, Bacher M, Nicoletti F, et al.

(16) The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agentsThe Journal of biological chemistryJuly 12, 2002Lubetsky JB, Dios A, Han J, Aljabari B, Ruzsicska B, Mitchell R, Lolis E, Al-Abed Y.

(17) Cerebrospinal fluid and ependymal neurophysinThe Journal of clinical investigationMay 1, 1973Robinson AG, Zimmerman EA.

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ISO-1 from MedChemExpress

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