MPTP hydrochloride from MedChemExpress

Product Specs
ItemMPTP hydrochloride
CompanyMedChemExpress
Price $66.00Supplier Page View Company Product Page
Catalog NumberHY-15608
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.82%
TypeChemical
Molecular Weight209.72
Molecule NameMPTP (hydrochloride)
FormulaC12H16ClN
Research AreaNeurological Disease; Cancer

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(1) Uric acid alleviates the inflammatory response in LPS-induced BV2 cells and MPTP-induced PD mice by resisting ferroptosis through the Nrf2 signalling pathwayRedox RepDecember 31, 2026Dongmei Zhou, Tian Xiong, Bing Yang, Fanjie Liu, Xianglai Mo, Ting Chen, Peipei Lu, Xinghuan Liang, Li Li, Yingfen Qin, et al.(Darmstadt, Germany). Probenecid (PBN, Cat. No. HY-B0545), ML385 (Cat. No. HY-100523), MPTP (Cat. No. HY-15608) and MPP+ (Cat. # HY-W008719) were purchased from MedChemExpress (New Jersey, U.S.A.). All antibodies

(2) Preventive Attenuation of MPTP-Induced Parkinson's Disease-like Abnormalities by Lactiplantibacillus plantarum SHOU LAC-1 in MiceFoodsSeptember 2, 2026Wenrui Zhao, Yaqin He, Houxiang Ma, Dongpin Tu, Jun Chen, Quancai Sun, Ye Peng, Zhiyao An, Pengcheng Pan, Wenhui Wu, et al.whereas mice in the Control group received an equivalent volume of sterile saline. MPTP hydrochloride (HY-15608), L-DOPA (HY-N0304), and benserazide hydrochloride (HY-B0404A) were purchased from MedChemExpress (Monmouth

(3) Striatal small RNA remodeling in MPTP-induced Parkinson’s disease highlights coordinated downregulation of mitochondrial tsRNAsFrontiers in Aging NeuroscienceAugust 24, 2026Mingyu Mao, Yan Wang, Qing Deng, Jun Xiang, Wentao Limodel, mice in the MPTP group received daily intraperitoneal injections of MPTP (MedChemExpress, cat.no.HY-15608) at a dose of 25 mg/kg for 10 consecutive days. Control mice received an equal volume of sterile saline

(4) Upregulated PKM2 Protects Dopaminergic Neurons From Oxidative Damage Through Nrf2 Transactivation in an MPTP-Induced Mouse Model of Parkinson's DiseaseCNS Neurosci TherJune 1, 2026Meng Mei, Qian-Qian Miao, Meng-Ke Li, Hao-Ran Wang, Jian-Hua Ding, Gang Hu, Yao WeiMouse Subacute PD Model The mice were subcutaneously injected with saline‐dissolved MPTP (20 mg/kg, HY‐15608, MedChemExpress, New Jersey, USA) once daily for five consecutive days [39, 49, 50]. Three days after

(5) Alterations in Phospholipid Levels and Spatial Distribution in the Motor Cortex and Their Correlation with Motor Performance in an MPTP-Induced Parkinsonian Mouse ModelMoleculesApril 2, 2026Morakot Sroyraya, Kunwadee Noonong, Prasert Sobhon, Tanapan Siangcham, Wanwisa Waiyaput, Veerawat Sansri, Kulathida Chaithirayanon, Pennapa Chonpathompikunlertsecondary antibody were purchased from Thermo Fisher Scientific Inc., Waltham, MA, USA. MPTP hydrochloride (HY-15608) was purchased from MedChemExpress (Monmouth Junction, NJ, USA). Bouin used as a fixative was obtained

(6) Zhigancao decoction alleviates Parkinson’s disease via inhibiting TNF/NF-κB and Ras/ERK-mediated neuroinflammation and apoptosisiScienceJanuary 16, 2026Jiakang Zhang, Xinlang Yu, Yuan Fang, Wenshan Li, Qi Cui, Xiaoyu Liu, Yanjie Jiang, Yin Zhang, Chengcheng Xu, Xin Sun, et al.peptides, and recombinant proteins","Chemicals, peptides, and recombinant proteins" ,, MPTP,MCE,Cat#HY-15608 L-DOPA,MCE,Cat#HY-N0304 MPP+,MCE,Cat#HY-W008719 Apigenin,Macklin,Cat#A800500 Bisdemethoxycurcumin,Sigma,Cat#33171-05-0 R-7050,MCE,Cat#HY-110203 ,, Critical

(7) UBC9 mediates mitophagy to attenuate oxidative stress by regulating SUMOylation of PINK1 in the Parkinson’s disease progressionCell Biology and ToxicologyDecember 6, 2025Jian Liu, Ge Jia, Yu Zhou, Junmei Zhang, Yanjin Wang, Yuxiang Caithe AAV-control adenovirus. Mice in sham group received normal saline solution. MPTP (25 mg/kg/day, HY-15608, MedChemExpress) was injected intraperitoneally for 5 days along with AVV-oe-NC or AVV-oe-UBC9. All

(8) Formononetin derived from Parabacteroides merdae alleviates MPTP-induced Parkinson’s disease in mice by inhibiting ferroptosis via the PI3K-AKT-ferritinophagy axisCommunications BiologyNovember 25, 2025Xuechao Dong, Teng Yang, Zheng Jin1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 15 mg/kg) for five consecutive days51. Briefly, MPTP hydrochloride (HY-15608, MCE) was dissolved in saline to achieve a final MPTP concentration of 15 mg/kg. Control mice were treated

(9) Aerobic exercise and gut flora: a key link to improved cognitive impairment in mice with Parkinson’s diseaseFrontiers in Aging NeuroscienceOctober 21, 2025Wen Peng Shan, Shi Lei Yan, Yuan Yuan Guo, Hua Ke Yang, Jing Chun Wang, Jie Xiangprevious study (Park et al., 2024), we made a PD mouse model with MPTP. First, we diluted MPTP (Cat#HY-15608, MedChemExpress, USA) to 3 mg/mL with sterile saline. At the same time, we made a 10 mg/mL solution

(10) GSDMD-Deficient G-MDSCs Exert Profoundly Suppressive Activity to Relieve MPTP-Induced Parkinson's DiseaseCNS Neurosci TherOctober 13, 2025Qi Wu, Fangzhou Liu, Min Gu, Junjie Wei, Guotao Lu, Li Qian, Xiaobo Li, Weijuan Gongpurchased from BioLegend (San Diego, CA, USA). 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP, HY‐15608) and ACT001 (HY‐128861A) were obtained from MedChemExpress (New Jersey, USA). LPS was acquired from

(11) Mitochondrial dysfunction-mediated metabolic remodeling of TCA cycle promotes Parkinson's disease through inhibition of H3K4me3 demethylationCell Death DiscovJuly 29, 2025Xiaoyuan Zhang, Fali Zhang, Yue Zeng, Aiying Li, Jiamao Yan, Pei Li, Kexin Qin, Teng Zhang, Jiaojiao Huang, Minghui Zhao, et al.water containing citrate (Sigma; 1% w/v) and intraperitoneal injection (i. p.) of MPTP (MedChemExpress, HY-15608; 30 mg/kg body weight) or vehicle treatment for 8th to 12th days; the behavioral teste and sampling

(12) Exploring the mechanism of metabolic cell death-related genes AKR1C2 and MAP1LC3A as biomarkers in Parkinson's diseaseSci RepJuly 15, 2025Jia Fu, Jing Zhao, Xue Zhao, Na Mi, Chao Zhang, Xueying Li, Lei Wu, Lige Han, Yali Zhang, Lifen Yaocontrol groups (n = 5/group) using a random number table method. MPTP hydrochloride (MCE, Cat. No. HY-15608) was dissolved in 0.9% saline and administered intraperitoneally (30 mg/kg/day) for 7 consecutive days.

(13) Dopaminergic Neuron-Derived AIMP1 Promotes Neurodegeneration via CD23-Dependent Microglial ActivationCNS Neurosci TherJune 16, 2025Qinqin Wang, Hao Yu, Xunan Yuan, Ruolin Li, Xuezhi Li, Shu Yin, Xiaodan Ma, Xinmiao WangRegents and Antibodies AIMP1 was purchased from MCE (HY‐P77643). MPTP was obtained from MedChem Express (HY‐15608). Anti‐AIMP1 antibody was a gift from Prof. Jiawei Zhou (CAS Center for Excellence in Brain Science

(14) Inhibition of tRF- 02514 in Extracellular Vesicles Preserves Microglia Pyroptosis and Protects Against Parkinson’s DiseaseMolecular NeurobiologyApril 21, 2025Xiaolin Dong, Qingyun Li, Rui Li, Yanping Li, Furong Jin, Hongmei Li, Kun Tu, Gang Wureceived an intraperitoneal injection of 1-methyl- 4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) (MCE, HY- 15608) at a dose of 20 mg/kg for 14 consecutive days, while control mice were administered an equivalent volume

(15) Distinct expression of NEAT1 isoforms in Parkinson's disease models suggests different roles of the variants during the disease courseSci RepApril 15, 2025Fanni Annamária Boros, Orsolya Horváth, Rita Maszlag-Török, Mária Baranyi, Nikolett Nánási, Orsolya Oláh-Németh, Beáta Sperlágh, László Vécsei, Péter Klivényicorresponding to the EtOH content of the solution for the highest SFN dose implemented). MPTP (cat.no.: HY-15608, MedChemExpress, NJ, USA) was dissolved in PBS and administered via i.p. injection. For the PSS model

(16) Antioxidant and neuroprotective effects of nutriosomes and grape pomace phytochemicals in a cell model of oxidative stress and mouse model of Parkinson diseaseSci RepApril 8, 2025Mohamad Allaw, Matteo Perra, Pathik Parekh, Marcello Serra, Jacopo Marongiu, Ines Castangia, Federica Fulgheri, Pierluigi Caboni, Giulia Tolle, Francesco Corrias, et al.were purchased from Life Technologies Europe (Monza, Italy). MPTP was purchased from MedChemExpress (HY-15608) and was dissolved in distilled water. Extraction process The extraction was performed as previously

(17) Fibrinogen degradation products exacerbate alpha-synuclein aggregation by inhibiting autophagy via downregulation of Beclin1 in multiple system atrophyNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeuticsMarch 1, 2025Liu H, Yu R, Zhang M, Zheng X, Zhong L, Yang W, Luo Y, Huang Z, Zheng J, Zhong H, et al.purchased from Sigma-Aldrich. Chloroquine and thrombin (T832140) were obtained from Macklin. MPTP (HY-15608) and 3-NP (HY-W012875) were purchased from MCE. The reactive oxygen species (ROS) detection kit and

(18) Malvidin-3-O-Glucoside Mitigates α-Syn and MPTP Co-Induced Oxidative Stress and Apoptosis in Human Microglial HMC3 CellsInternational Journal of Molecular SciencesNovember 27, 2024Rachit Sood, Sanjay, Sung-Ung Kang, Na Young Yoon, Hae-Jeung LeeAbcam (Cambridge, UK). M3G (CFN92049) was provided by ChemFaces (Wuhan, China). MPTP hydrochloride (HY-15608) and Nrf2 inhibitor ML385 (HY-100523) were obtained from MedChemExpress LLC (Princeton, NJ, USA). Dulbecco’s

(19) SHANK2-AS3: A potential biomarker for Parkinson's disease and its role in neuronal apoptosis via NF-κB signaling in SH-SY5Y cellsHeliyonNovember 15, 2024Qiong Huang, Dani Qin, Chunyan Chen, Yu Kang, Haocong Chen, Min Xu, Rao Fu, Xiaohua Dongmaintained at 37 °C with 5 % CO2 in cell incubator. MPTP were purchased from MedChamExpress company (MCE, HY-15608). MPTP at different concentration (2 mM, 4 mM, and 8 mM) was added to the medium and incubated for 24

(20) Umbilical cord blood-derived exosomes attenuate dopaminergic neuron damage of Parkinson's disease mouse modelJournal of NanobiotechnologySeptember 14, 2024Junjie Ye, Xiaodong Sun, Qi Jiang, Jianjun Gui, Shenglan Feng, Bingqing Qin, Lixia Xie, Ai Guo, Jinju Dong, Ming Sang(111–035-003) and goat anti-mouse IgG (115-035-003) were purchased from Jackson ImmunoResearch (USA). MPTP (HY-15608) was obtained from MedChemExpress, and MPP+ (36913-39-0) was obtained from Sigma. 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine

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MPTP hydrochloride from MedChemExpress

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MPTP hydrochloride from MedChemExpress

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