BV6 from MedChemExpress

Product Specs
ItemBV6
CompanyMedChemExpress
Price $252.00Supplier Page View Company Product Page
Catalog NumberHY-16701
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.90%
TypeChemical
Molecular Weight1205.57
FormulaC₇₀H₉₆N₁₀O₈
Research AreaCancer

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(1) Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functionsCell Death DisOctober 6, 2025Juliette Tokgozoglu, Valeria Pistorio, Mirko Minini, Pierre-Antoine Soret, Virginie Steunou, Jean-Louis Delaunay, Julien Castel, Serge Luquet, Ivan Nemazanyy, Carine Beaupère, et al.Z-VAD(OMe)-FMK (20 µmol/L, #HY-16658, MedChemExpress, NJ, USA), a cIAP1/2 inhibitor, BV-6 (10 µmol/L, #HY-16701, MedChemExpress) 2 h before TNF-α stimulation (20 ng/ml, #315-01 A, PeproTech, Neuilly-sur-Seine, Paris).

(2) Reprogramming RIPK3-induced cell death in malignant B cells promotes immune-mediated tumor controlSci AdvAugust 15, 2025Ruby Alonso, Zacarias Garcia, Béatrice Corre, Fabrice Lemaître, Camille Vaganay, Hélène Saklani, Capucine L. Grandjean, Nader Yatim, Philippe BoussoMedChemExpress). Pro-B cells expressing or lacking endogenous RIPK3 (RIPK3−/− pro-B) were treated with BV6 (5 μM; HY-16701, CliniSciences) to favor apoptosis induction or BV6 (5 μM) plus emricasan (5 μM; HY-10396, CliniSciences)

(3) Impact of protein and small molecule interactions on kinase conformationsElifeAugust 1, 2024Valentina Kugler, Selina Schwaighofer, Andreas Feichtner, Florian Enzler, Jakob Fleischmann, Sophie Strich, Sarah Schwarz, Rebecca Wilson, Philipp Tschaikner, Jakob Troppmair, et al.Chem Express, HY-P7090A), z-VAD(OMe)-FMK (MCE Med Chem Express, HY-16658), BV6 (MCE Med Chem Express, HY-16701). Representation of data In Figure 1E and F, representative experiments of n=4 independent experiments

(4) Impact of protein and small molecule interactions on kinase conformationseLifeAugust 1, 2024Valentina Kugler, Selina Schwaighofer, Andreas Feichtner, Florian Enzler, Jakob Fleischmann, Sophie Strich, Sarah Schwarz, Rebecca Wilson, Philipp Tschaikner, Jakob Troppmair, et al.Chem Express, HY-P7090A), z-VAD(OMe)-FMK (MCE Med Chem Express, HY-16658), BV6 (MCE Med Chem Express, HY-16701). Representation of data In Figure 1E and F, representative experiments of n=4 independent experiments

(5) Targeting P2Y(14)R protects against necroptosis of intestinal epithelial cells through PKA/CREB/RIPK1 axis in ulcerative colitisNature communicationsMarch 7, 2024Liu C, Wang H, Han L, Zhu Y, Ni S, Zhi J, Yang X, Zhi J, Sheng T, Li H, et al.(20 ng·mL−1) (HY-P70426A, MCE) plus z‐VAD‐fmk (20 μM) (HY-16658B, MCE) and Smac mimetic (BV6, 2 μM) (HY-16701, MCE) for 12 h, then stained cells with 50 µg ml−1 PI for 20 min. Dead cell imaging in live organoids

(6) The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytesiScienceOctober 21, 2022Magusto J, Beaupère C, Afonso MB, Auclair M, Delaunay JL, Soret PA, Courtois G, Aït-Slimane T, Housset C, Jéru I, et al.Z-VAD(OMe)-FMK (20 μmol/L, #HY-16658, MedChemExpress, NJ, USA), a cIAP1/2 inhibitor, BV-6 (10 μmol/L, #HY-16701, MedChemExpress) and an inhibitor of protein synthesis, cycloheximide (CHX) (0.5 μg/mL, #C4859, Sigma-Aldrich)

(7) Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosusNature communicationsMarch 19, 2018Liu J, Huang X, Hao S, Wang Y, Liu M, Xu J, Zhang X, Yu T, Gan S, Dai D, et al.130-049−201) and CD45R (B220, 130-049-501) MicroBeads were purchased from Miltenyl Biotec. Smac mimetic BV6 (HY-16701) was from MCE. MG132 (C2211) and LPS (L3129) were from Sigma. The anti-IgM (115-006-075 for B cell stimulation)

(8) Structural mechanisms of heavy-metal extrusion by the Cus efflux systemBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicineAugust 1, 2013Delmar JA, Su CC, Yu EW.

(9) BV6, an IAP antagonist, activates apoptosis and enhances radiosensitization of non-small cell lung carcinoma in vitroJournal of thoracic oncology : official publication of the International Association for the Study of Lung CancerNovember 1, 2011Li W, Li B, Giacalone NJ, Torossian A, Sun Y, Niu K, Lin-Tsai O, Lu B.

(10) RIPK1 and RIPK3 regulate TNFα-induced β-cell death in concert with caspase activityMolecular metabolismJanuary 1, 0001"Contreras CJ, Mukherjee N, Branco RCS, Lin L, Hogan MF, Cai EP, Oberst AA, Kahn SE, Templin AT."G7232, Promega, Madison, WI), TNFα (40 ng/ml, mouse: CYT-252, Prospec, Rehovot, Israel), BV6 (5 μM, HY-16701, MedChemExpress, Monmouth Junction, NJ), GSK’872 (5 μM, HY-101872, MedChemExpress). 2.3 Quantitative

(11) Inhibitor of apoptosis proteins (IAPs) may be effective therapeutic targets for treating endometriosis"Human reproduction (Oxford, England)"January 1, 0001"Uegaki T, Taniguchi F, Nakamura K, Osaki M, Okada F, Yamamoto O, Harada T."

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