RN486 from MedChemExpress | Biocompare.com

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RN486

Description

RN486 is a potent, selective and orally active Btk inhibitor with an IC₅₀ of 4.0 nM and a K_d of 0.31 nM. RN486 is less active for other kinases. RN486 can be used for rheumatoid arthritis and systemic lupus erythematosus research

Product Specs
ItemRN486
CompanyMedChemExpress
Price $174.00Supplier Page View Company Product Page
Catalog NumberHY-18018
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity98.91%
TypeChemical
Molecular Weight606.69
FormulaC₃₅H₃₅FN₆O₃
Research AreaInflammation/Immunology

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(1) Suppression of glomerulonephritis in lupus-prone NZB × NZW mice by RN486, a selective inhibitor of Bruton's tyrosine kinaseArthritis and rheumatismSeptember 1, 2013Mina-Osorio P, LaStant J, Keirstead N, Whittard T, Ayala J, Stefanova S, Garrido R, Dimaano N, Hilton H, Giron M, et al.

(2) Bruton's Tyrosine Kinase mediates platelet receptor-induced generation of microparticles: a potential mechanism for amplification of inflammatory responses in rheumatoid arthritis synovial jointsImmunology lettersFebruary 1, 2013Hsu J, Gu Y, Tan SL, Narula S, DeMartino JA, Liao C.

(3) RN486, a selective Bruton's tyrosine kinase inhibitor, abrogates immune hypersensitivity responses and arthritis in rodentsThe Journal of pharmacology and experimental therapeuticsApril 1, 2012Xu D, Kim Y, Postelnek J, Vu MD, Hu DQ, Liao C, Bradshaw M, Hsu J, Zhang J, Pashine A, et al.

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