XAV-939 from MedChemExpress

Product Specs
ItemXAV-939
CompanyMedChemExpress
Price $66.00Supplier Page View Company Product Page
Catalog NumberHY-15147
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.91%
TypeChemical
Molecular Weight312.31
FormulaC₁₄H₁₁F₃N₂OS
Research AreaCancer

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(1) TGFβ-dependent upregulation of OCIAD2 is essential for epithelial-to-mesenchymal transition during mesendoderm differentiationStem Cell ReportsSeptember 8, 2026Kajal Kamat, Maneesha S. InamdarE1905 Sodium acetate,Sigma Aldrich,Cat#S5636 CHIR99021,Sigma Aldrich,Cat#SML1046 XAV939,MedChemExpress,Cat#HY-15147 Prestoblue,Thermo Fisher Scientific,Cat#A13261 Y-27632 dihydrochloride,Sigma Aldrich,Cat#Y0503 2-NBDG,Invitrogen,Cat#

(2) Esculentoside A suppresses the malignant progression of hepatocellular carcinoma by promoting RORBCell DivisionJune 3, 2026Qing Ye, Dousheng Bai, Aoqing Wang, Xi Zhang, Ruiqi Chaiapplied to HCC cell lines for 48 h, followed by 24-hour treatment with 10 µmol/L XAV-939 (purity: 99.80%, HY-15147, MedChemExpress, Monmouth Junction, NJ, USA) [33]. The control group was treated with an equivalent

(3) Effects of SOX10 on the proliferative, invasive, migratory, and epithelial–mesenchymal transition abilities of triple-negative breast cancer cellsFrontiers in OncologyMay 18, 2026Shuai Wang, Linfang Jinconcentration of 5 μM (8), and inhibited using XAV939 (a tankyrase 1/2 inhibitor; MedChemExpress, Cat. No. HY-15147) at a concentration of 10 μM (13). Both compounds were dissolved in dimethyl sulfoxide (DMSO) to prepare

(4) DKC1 promotes colorectal cancer progression and therapy resistance by dysregulating sphingolipid biosynthesisNat CommunMay 18, 2026Umar K. Khan, Ayush Goel, Shivansh Nigam, Nazia Chaudhary, Ayush Praveen, Anjan Roy, Fabeha Fatima, Dilpreet K. Sawhney, Afiya Dalwai, Akshay Shendre, et al.was plotted. For experiments with WNT inhibitor, media was supplemented with XAV939 (MedChemExpress, HY-15147) and replaced every 24 h. For doxycycline induced DKC1 silencing experiment, SW620 shSCRM and shDKC1

(5) Tempol Protects Against Radiation Injury in the Submandibular Gland Through the β‐Catenin Signaling PathwayJournal of Oral Pathology & MedicineMay 14, 2026Jinfeng Wang, Mingjun Xu, Jinghua Zhong, Kui Zhong, Zheng Chen, Chunyu Liu, Chao LiuIR + TPL). Where indicated, cells were treated with the β‐catenin pathway inhibitor XAV939 (100 μM; HY‐15147, MedChemExpress) for 8 h, with or without 8 mM TPL for 10 min, prior to irradiation with 6 Gy (groups:

(6) Exploring the efficacy of XAV939 and LF3 in targeting β-catenin signalling in gallbladder cancer cell linesDiscover OncologyMay 11, 2026Akanksha Kashyap, Sheikh Mohammad Umar, Arundhathi J. R. Dev, Nisha Manav, Prasenjit Das, Sunil Kumar, R. Chethan, Chandra Prakash Prasadcells were exposed to varying concentrations of β-catenin inhibitors, XAV939 (MedChemExpress, USA, HY15147) and LF3 (SelleckChem, USA, S8474) for 48 h. After treatment, 10 µL of 5 mg/mL MTT ((3- (4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium

(7) Isoginkgetin protects against degeneration of ALS motor neurons via regulating the GSK-3β–TFEB signaling axisPharmacological ResearchMay 1, 2026Ang Li, Xianglu Xiao, Guopan Liu, Krinos Li, Yixia Ling, Shenglong Deng, Chunzuan Xu, Shu-qin Cao, Jing Wen, Guang Lu, et al.Isoginkgetin (HY-N2117; MCE; Dissolved in DMSO), Torin 1 (HY-13003; MCE), BI-D1870 (HY-10510; MCE), XAV-939 (HY-15147; MCE), LY294002 (HY-10108; MCE), Go6976 (HY-10183; MCE), ATP (HY-B2176; MCE), N2 (17502–048; Gibco),

(8) Flavonoids of Cuscuta chinensis Enhance Osteogenic Differentiation in Dental Pulp Stem Cells via the Regulation of Wnt/β-Catenin SignalingPrev Nutr Food SciApril 20, 2026Jianghua Yang, Xiyuan Guo, Jingang Xiao, Fahsai KantawongSolarbio Science & Technology Co., Ltd., TFCC from DESITE, and the Wnt inhibitor－XAV-939 (Cat. no. HY-15147)－was from MCE. The alkaline phosphatase (ALP) staining kit and Alizarin red S solution (Cat. no. C0138)

(9) Enhancing reprogramming towards induced human expanded pluripotency through substitution of SOX2 with engineered SOX17 transcription factorsCommunications BiologyApril 9, 2026Haoqing Hu, Derek Hoi Hang Ho, Shi Wing Yeung, Yuebin Tan, Sik Yin Ho, Mingxi Weng, Degong Ruan, Ralf Jauch(Corning, #25023CI), 3.3 μg per mL l-glutathione reduced (Sigma, #G4251-300MG), 1 μM XAV-939 (MCE, #HY-15147), 2.5 μM IWR-1-endo (MCE, #HY-12238), 1 μM CHIR-99021 (MCE, #HY-10182), 0.1 μM A-419259 (MCE, #HY-15764).

(10) Canonical Wnt signaling affects calcium homeostasis in serum-treated AC16 cells through MLN-mediated SERCA2a regulationJournal of Molecular Cell BiologyApril 3, 2026Ang Li, Yuanyuan Shen, Zhenyan Li, Wenyu Jiang, Jie Su, Xiaomin Song, Lin Livarious compounds, including SFRP1/2 (MedChemExpress, HY-P74554 and HY-P77835), XAV939 (MedChemExpress, HY-15147), LF3 (MedChemExpress, HY-101486), LiCl (Sigma, 656984), thapsigargin (MedChem-Express, HY-13433), KN-62

(11) Dysregulation of the Cant1/β-Catenin/TCF4–CHSY1 Axis Underpins Impaired ECM Biosynthesis in Skeletal DisordersResearch (Wash D C)April 1, 2026Yuanliang Li, Wenqi Yu, Yingxin Li, Kai Liu, Wenjing Xu, Cong Li, Yugu Li, Ying Li, Zhaoxin Tang, Yung-Fu Chang, et al.cultured in DMEM/F12 containing 5 mM lithium chloride (no. R30508, Shyuanye, China) or 10 μM XAV-939 (no. HY-15147, MedChemExpress, China) for 48 h. Cells were then washed with phosphate-buffered saline (PBS), quenched

(12) Downregulation of the host ribonucleotide reductase subunit M2 via the Wnt/β-catenin pathway is a novel mechanism for duck plague virus replication and a potential antiviral targetPoult SciMarch 5, 2026Qiqi Yang, Shun Chen, Renyong Jia, Mafeng Liu, Qiao Yang, Bin Tian, Xumin Ou, Zhen Wu, Juan Huang, Di Sun, et al.4408-78-0) was added to DEF cells at 200 μg/mL. The Wnt signaling pathway inhibitor XAV939 (MedChemExpress, HY-15147) and the Wnt signaling pathway activator Laduviglusib (MedChemExpress, HY-10182) were used at 40 μM

(13) Gpc3 selectively suppresses subcutaneous adipogenesis in diet-induced obesityPLoS BiolMarch 4, 2026Yan Li, Ming Tao, Carlos F. Ibáñez, Meng XieGSK3 inhibitor CHIR99021 (MedChemExpress, HY-10182) and Tankyrase inhibitor XAV939 (MedChemExpress, HY-15147) were applied from DIV 0–7. Oil Red O staining and quantification Cells were washed three times with

(14) β-Catenin–Facilitated Glycolytic Reprogramming Fuels TNBC Progression: Therapeutic Blockade with XAV939Technology in Cancer Research & TreatmentFebruary 17, 2026Sheikh Mohammad Umar, Shruti Kahol, Sandeep R. Mathur, Ajay Gogia, S.V.S. Deo, Shivam Pandey, Chandra Prakash Prasadfunctions. β-Catenin Inhibitor For the present study, XAV939 [Mol. Wt. 312.3 g/mol; C₁₄H₁₁F₃N₂OS; #HY15147, MedChemExpress (NJ, USA)] was used to inhibit β-catenin. XAV939 targets tankyrase (TNKS) 1 and 2, two

(15) Berberine augments the secretory function of salivary gland in homeostasis and after radiation exposureFrontiers in ImmunologyJanuary 12, 2026Qihang Lian, Yue Tian, Nan Wang, Yikun Luo, Xi Wang, Banghui Liu, Hefei Tian, Xiangjun Liu, Qingping Yin, Zhenni Xu, et al.medium independently or in the combination of either 80 mM LiCl (HY-Y0649, MCE, China) or 5 µM XAV939 (HY-15147, MCE, China). For the radiation experiments, SGOs were firstly cultured for 5 days and then irradiated

(16) Wnt3a-expressing cancer stem cells impair CD8(+) TRM function, contributing to immunotherapy resistance in MelanomaOncoimmunologyDecember 31, 2025Gajón JA, Juarez-Flores A, Mendoza-Roldan F, Hernandez-Aceves J, Muñoz-Cruz S, Perez-Torres A, Fuentes-Panana EM, Bonifaz LC.mice bearing MO4, R1, or R2 tumours were administered 10 mg/kg of XAV939 (MedChemExpress, Catalogue: HY−15147) intraperitoneally every other day starting on day 14 post-inoculation. Beginning on day 20, mice received

(17) CBX4 Drives Gastric Cancer Progression by Activating β-Catenin SignalingOncology ResearchDecember 30, 2025Wendong Jia, Ting Zhang, Ziying Zhang, Lingzhi Wu, Xihao Fu, Zhenxin Wang, Ni YinLipofectamine 2000 (11668019) was supplied by Thermo Fisher Scientific (Waltham, MA, USA). XAV939 (HY-15147) was supplied by MCE (Monmouth Junction, NJ, USA). The dual-luciferase (LUC) assay system (E2920) was

(18) Tanshinone IIA suppresses fibro-adipogenic progenitor differentiation and attenuates fat infiltration in rotator cuff injury via Wnt/β-catenin pathwayRegenerative therapyDecember 1, 2025Zhang Y, Li X, Zhang R, Wang M, Wang T, Liu G, Kuati A, Mao W.(MedChemExpress, cat#HY-N0135)、KYA797K (MedChemExpress, cat#HY-101090) and XAV-939 (MedChemExpress, cat#HY-15147). The obtained FAPs were proliferated in αMEM (Gibco, cat#10712124) containing 10 % fetal bovine serum

(19) YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated DeubiquitinationAdvanced ScienceNovember 26, 2025Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, et al.were purchased from Selleck and Proteintech, respectively. P5091 (HY‐15667) and Wnt inhibitor XAV‐939 (HY‐15147) were obtained from MedChemExpress. CQ was acquired from Selleck (S6999), and MG132 was obtained from

(20) Pan-cancer analysis of role of LOXL4 and experiment validation in osteosarcomaDiscov OncolOctober 21, 2025Wenjie Chen, Fujie Xie, Jie Lv, Dixi Huang, Ronghao Zhong, Zhijia Wen, Jiangsen Sun, Shaowei Zheng, Weile Liu, Haobo Zhong, et al.Goat anti-rabbit IgG H&L (HRP) (ab205718, 1:30000, Abcam). MCE (USA) provided the pathway inhibitor XAV-939 (HY-15147). Colony formation assays A cell suspension containing 200 quantified viable cells was plated into

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XAV-939 from MedChemExpress

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XAV-939 from MedChemExpress

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