Dinaciclib from MedChemExpress

Product Specs
ItemDinaciclib
CompanyMedChemExpress
Price $99.00Supplier Page View Company Product Page
Catalog NumberHY-10492
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.80%
FormulaC21H28N6O2
Research AreaCancer
TypeChemical
Molecular Weight396.49
Quantity10 mM * 1 mL
Molecule NameDinaciclib

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(1) Essential lncRNAs in the human transcriptomeCell GenomicsJuly 8, 2026Wen-Wei Liang, Simon J. Mueller, Sydney K. Hart, Hans-Hermann Wessels, Alejandro Méndez-Mancilla, Akash Sookdeo, Olivia Choi, Christina M. Caragine, Alba Corman, Lu Lu, et al.compounds that inhibit cell cycle progression, the CDK1/2/5/9 inhibitor dinaciclib (0.5 μM, MedChemExpress HY-10492) and the DNA damage-inducing agent doxorubicin (1 μM, MedChemExpress HY-15142), which trigger G1-S and

(2) Combining anti-gene γPNA with small molecules and RNA inhibitors: A strategy to enhance anti-tumor efficacyMolecular Therapy Nucleic AcidsMarch 12, 2026Sai Pallavi Pradeep, Brooke Elizabeth DiVasto, Peter M. Glazer, Raman BahalγPNA1 and ScR-γPNA2 at 8 μM for 72 h. MDA-MB 231 cells were cotreated with dinaciclid (MedChemExpress, #HY-10492) and γPNA1 and ScR-γPNA2 at 8 μM for 72 h. MDA-MB-231 and HeLa cells were cotreated with c-Myc siRNA

(3) Differential cell survival outcomes in response to diverse amino acid stressLife science allianceNovember 1, 2025Russier M, Fiore A, Bici A, Groß A, Tanzer M, Yeroslaviz A, Mann M, Murray PJ.resuspended in water), 1 μM RSL3 (S8155; SelleckChem), SHIN1 (HY-112066; MedChemExpress). Dinaciclib (HY-10492; MedChemExpress) and palbociclib (S1116; SelleckChem, resuspended in water) were used to inhibit CDK1/2/5/9

(4) Small Molecule Screening Identifies HSP90 as a Modifier of RNA Foci in Myotonic Dystrophy Type 1Molecular and Cellular BiologyJune 3, 2025Sara J. Johnson, Hannah L. Johnson, Reid T. Powell, Clifford Stephan, Fabio Stossi, Thomas A. CooperSNS-032 (CAS 345627–80-7 MedChemExpress HY-10008/CS-0021), Dinacilib (CAS 779353–01-4 MedChemExpress HY-10492/CS-0541), AZD6482 (CAS 1173900–33-8 APEXBIO A5478), Homoharringtonine (CAS Enzo ALX-350–236-M005), Chromomycin A3

(5) RNA sequencing identifies lung cancer lineage and facilitates drug repositioningPeerJSeptember 24, 2024Longjin Zeng, Longyao Zhang, Lingchen Li, Xingyun Liao, Chenrui Yin, Lincheng Zhang, Xiewan Chen, Jianguo Sunviability was estimated by CCK-8 assay. BEAS-2B and H1944 cell lines were co-cultured with Dinaciclib (HY-10492; MedChemExpress, Monmouth Junction, NJ, USA) for 48 and 72 h, respectively. Meanwhile, treatment of

(6) Regulated induced proximity targeting chimeras-RIPTACs-A heterobifunctional small molecule strategy for cancer selective therapiesCell chemical biologyAugust 15, 2024Raina K, Forbes CD, Stronk R, Rappi JP Jr, Eastman KJ, Zaware N, Yu X, Li H, Bhardwaj A, Gerritz SW, et al.765.3924 Reagents: TAMRA-CA was purchased from Promega (G8251). JQ-1 (HY-13030), BI-2536 (HY-50698), dinaciclib (HY-10492) were purchased from MedChemExpress. Alexa Fluor 647 phalloidin (A22287) and DAPI (62247) were bought

(7) FOXK2 amplification promotes breast cancer development and chemoresistanceCancer LettersAugust 10, 2024Yang Yu, Wen-Ming Cao, Feng Cheng, Zhongcheng Shi, Lili Han, Jinling Yi, Edaise M. da Silva, Higinio Dopeso, Hui Chen, Jianhua Yang, et al.(F6627), and dichloroacetate (DCA; 347795) were from Sigma-Aldrich. The CDK2 inhibitors dinaciclib (HY-10492) and alpelisib (BYL-719, HY-15244) were from MedChemExpress. 2.3. Fluorescence in situ hybridization A

(8) CDK9 inhibition as an effective therapy for small cell lung cancerCell Death & DiseaseMay 20, 2024L. Valdez Capuccino, T. Kleitke, B. Szokol, L. Svajda, F. Martin, F. Bonechi, M. Krekó, S. Azami, A. Montinaro, Y. Wang, et al.10% (Hydroxypropyl Beta Cyclodextrin; #C0926-5G Sigma) or dinaciclib at 30 mg/kg (MedChemExpress, #HY-10492, Lot#120243) twice per week, every 2 weeks, until tumours reached a size of 800 mm3, at which point

(9) MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastomaJournal of experimental & clinical cancer research : CRAugust 21, 2023Pitolli C, Marini A, Guerra M, Pieraccioli M, Marabitti V, Palluzzi F, Giacò L, Tamburrini G, Cecconi F, Nazio F, et al.sc-391691, Santa Cruz Biotechnology), Indisulam (Cat. No. HY-13650, MedChemExpress), Dinaciclib (Cat. No. HY-10492, MedChemExpress), THZ1 (Cat. No. HY-80013, MedChemExpress), THZ531 (Cat. No. HY-103618, MedChemExpress),

(10) FOXK2 amplification and overexpression promotes breast cancer development and chemoresistancebioRxivJune 2, 2023Yang Yu, Wen-Ming Cao, Feng Cheng, Zhongcheng Shi, Lili Han, Jin-Ling Yi, Edaise M da Silva, Higinio Dopeso, Hui Chen, Jianhua Yang, et al.F6627), and Dichloroacetate (DCA) (347795) were from Sigma (St. Louis, MO). CDK2 inhibitors, Dinaciclib (HY-10492) and Alpelisib (BYL-719, HY-15244), were from MedChemExpress (Monmouth Junction, NJ). Fluorescence in situ hybridization

(11) A hybrid deep forest-based method for predicting synergistic drug combinationsCell Reports MethodsFebruary 27, 2023Lianlian Wu, Jie Gao, Yixin Zhang, Binsheng Sui, Yuqi Wen, Qingqiang Wu, Kunhong Liu, Song He, Xiaochen Boinhibitor,MedChemExpress(MCE),HY-13629; CAS: 33419-42-0 Dinaciclib CDK inhibitor,MedChemExpress(MCE),HY-10492; CAS: 779353-01-4 ,, Critical commercial assays,Critical commercial assays,Critical commercial assays ,, Counting

(12) Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells SelectivelybioRxiv : the preprint server for biologyJanuary 2, 2023Raina K, Forbes CD, Stronk R, Rappi JP Jr, Eastman KJ, Gerritz SW, Yu X, Li H, Bhardwaj A, Forgione M, et al.otherwise. TAMRA-CA was purchased from Promega (G8251). JQ-1 (HY-13030), BI-2536 (HY-50698), Dinaciclib (HY-10492) were purchased from MedChemExpress. Chemical Synthesis: RIPTAC synthesis and characterization provided

(13) Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor–mediated synergistic antileukemic actionsScience AdvancesSeptember 16, 2022Pu Zhang et al.doses: the first cohort: weekly intraperitoneal injections of dinaciclib (10 mg/kg ) (MedChemExpress, HY-10492) in 20% cyclodextrin (CTD THPB-P) diluted just before injection, daily oral gavage of gilteritinib (30

(14) Cyclin-Dependent Kinase Inhibitors Function as Potential Immune Regulators via Inducing Pyroptosis in Triple Negative Breast CancerFrontiers in OncologyJune 8, 2022Tao Xu, Zhen Wang, Jiahao Liu, Ge Wang, Dongchen Zhou, Yaying Du, Xingrui Li, Yu Xia, Qinglei Gaowith 5% CO2. GW-8510 (CAS 222036-17-1) was pursued from Santa Cruz Biotechnology, Inc. Dinaciclib (HY-10492), and Palbociclib (HY-50767) were pursued from MedChemExpress. Cytotoxic Assay BT549, MDA-MB-231,

(15) The role of E26 transformation-specific variant transcription factor 5 in colorectal cancer cell proliferation and cell cycle progressionCell Death & DiseaseMay 1, 2021Yi Peng, Haoran Feng, Changgang Wang, Zijia Song, Yaqi Zhang, Kun Liu, Xi Cheng, Ren ZhaoCDK inhibitor that inhibits CDK2, CDK5, CDK1, and CDK9, was purchased from MedChemExpress (Cat. No. HY-10492, USA). Generation of gene overexpression and knockdown cells Lentivirus for ETV5 overexpression and

(16) Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosisNature communicationsApril 23, 2021Ferreira APA, Casamento A, Carrillo Roas S, Halff EF, Panambalana J, Subramaniam S, Schützenhofer K, Chan Wah Hak L, McGourty K, Thalassinos K, et al.(called CK2i in this study, Cayman 16779), Dinaciclib (called Cdk1/2/5/9i in this study, MedChemExpress Hy-10492), Dobutamine (Sigma D0676), D4476 (called CK1i in this study, BioVision 1770), GDC-0879 (called BRAFi

(17) Discovery of Widespread Host Protein Interactions with the Pre-replicated Genome of CHIKV Using VIR-CLASPMolecular cellMay 21, 2020Kim B, Arcos S, Rothamel K, Jian J, Rose KL, McDonald WH, Bian Y, Reasoner S, Barrows NJ, Bradrick S, et al.previously described (Barrows et al., 2019). Cells were treated with the following reagents: Dinaciclib (HY-10492) was from MedChemExpress; Actinomycin D (A9415) and Cerulenin (219557) were from Sigma; Ruxolitinib

(18) Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft modelsCancer biology & therapyOctober 1, 2011Feldmann G, Mishra A, Bisht S, Karikari C, Garrido-Laguna I, Rasheed Z, Ottenhof NA, Dadon T, Alvarez H, Fendrich V, et al.

(19) Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitorMolecular cancer therapeuticsAugust 1, 2010Parry D, Guzi T, Shanahan F, Davis N, Prabhavalkar D, Wiswell D, Seghezzi W, Paruch K, Dwyer MP, Doll R, et al.

(20) CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibitionNatureJanuary 1, 0001"Gallo D, Young JTF, Fourtounis J, Martino G, Álvarez-Quilón A, Bernier C, Duffy NM, Papp R, Roulston A, Stocco R, et al."RP-6306 (this study), RP-6421 (this study) AZD1775 (Selleckchem, S1525), dinaciclib (MedChemExpress, HY-10492), PF-06873600 (MedChemExpress, HY-114177), RO-3306 (Selleckchem, S7747), gemcitabine (Cayman Chemicals,

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Dinaciclib from MedChemExpress

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Dinaciclib from MedChemExpress

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