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Protein Biochemistry
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PHA-793887
PHA-793887 from MedChemExpress
Be the first to write a review!
Citations:
(6)
Supplier Page
Supplier Page from
MedChemExpress for
PHA-793887
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Description
PHA-793887 is a potent, ATP-competitive
CDK
inhibitor, can inhibit Cdk2, Cdk1, Cdk4, and Cdk9 with
IC
50
s of 8 nM, 60 nM, 62 nM and 138 nM, respectively, and also inhibits glycogen synthase kinase 3β with an
IC
50
of 79 nM
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
PHA-793887
Company
MedChemExpress
Price
$61.00
Supplier Page
View Company Product Page
Catalog Number
HY-11001
Quantity
10 mM * 1 mL
Applications
Bioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity
99.25%
Type
Chemical
Molecular Weight
361.48
Formula
C₁₉H₃₁N₅O₂
Research Area
Cancer
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MedChemExpress
1 Deer Park Drive, Suite F
MONMOUTH JUNCTION
,
NJ
08852
United States
Phone
: US Tel: 609-228-6898
US Fax: 609-228-5909
EU Tel: +4686500910
Email: sales@medchemexpress.com
eu.sales@MedChemExpress.com
Company Profile
Website:
medchemexpress.com
Citations (6)
(1)
Fibroblast growth factor receptor risk signature predicts patient prognosis and immunotherapy resistance in colorectal cancer
Frontiers in Immunology
November 29, 2024
Xiaofang Li, Zhiling Pan, Tiankuo Luan, Qian Xiao, Liuying Li, Qianxue Wu, Guoqing Yao, Xiang Zhang, Daqiang Song
MC38
tumors
were subjected to treatment with either a control vehicle or
PHA-793887
(
MedChemExpress
,
HY-11001
), administered at a dosage of 10 mg/kg. Post-treatment, the excised
tumor
tissues underwent
flow cytometric analysis
(2)
Pan-Cancer analysis and experimental validation identify the oncogenic nature of ESPL1: Potential therapeutic target in colorectal cancer
Frontiers in Immunology
March 16, 2023
Yuchen Zhong, Chaojing Zheng, Weiyuan Zhang, Hongyu Wu, Meng Wang, Qian Zhang, Haiyang Feng, Guiyu Wang
(
IntestiCult™ Organoid Growth Medium (Human
), Cat.
06010
). 2.10 Drug
sensitivity
assay
PHA-793887
(
HY-11001
),
PAC-1
(
HY-13523
), and
AZD-7762
(
HY-10992
) were purchased from
MCE
(https://www.medchemexpress.com/).
(3)
A first in man, phase I dose-escalation study of PHA-793887, an inhibitor of multiple cyclin-dependent kinases (CDK2, 1 and 4) reveals unexpected hepatotoxicity in patients with solid tumors
Cell cycle (Georgetown, Tex.)
March 15, 2011
Massard C, Soria JC, Anthoney DA, Proctor A, Scaburri A, Pacciarini MA, Laffranchi B, Pellizzoni C, Kroemer G, Armand JP,
et al
.
(4)
Transcriptional analysis of an E2F gene signature as a biomarker of activity of the cyclin-dependent kinase inhibitor PHA-793887 in tumor and skin biopsies from a phase I clinical study
Molecular cancer therapeutics
May 1, 2010
Locatelli G, Bosotti R, Ciomei M, Brasca MG, Calogero R, Mercurio C, Fiorentini F, Bertolotti M, Scacheri E, Scaburri A,
et al
.
(5)
Therapeutic efficacy of the pan-cdk inhibitor PHA-793887 in vitro and in vivo in engraftment and high-burden leukemia models
Experimental hematology
April 1, 2010
Alzani R, Pedrini O, Albanese C, Ceruti R, Casolaro A, Patton V, Colotta F, Rambaldi A, Introna M, Pesenti E,
et al
.
(6)
Optimization of 6,6-dimethyl pyrrolo[3,4-c]pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing
Bioorganic & medicinal chemistry
March 1, 2010
Brasca MG, Albanese C, Alzani R, Amici R, Avanzi N, Ballinari D, Bischoff J, Borghi D, Casale E, Croci V,
et al
.
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PHA-793887 from MedChemExpress
Supplier Page
View Company Product Page
$61.00
Product Specs
Company Info
Citations
Reviews
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