Pifithrin-α hydrobromide from MedChemExpress

Product Specs
ItemPifithrin-α hydrobromide
CompanyMedChemExpress
Price $73.00Supplier Page View Company Product Page
Catalog NumberHY-15484
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity98.58%
TypeChemical
Molecular Weight367.3
FormulaC₁₆H₁₉BrN₂OS
Research AreaCancer

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(1) Anti-glioma mechanism of Angelica sinensis and stigmasterol: p53-associated ferroptosis identified via multi-method analysisScientific ReportsMay 13, 2026XueJiao Jiang, YuanYing Wang, YuDan Wang, YuTong Wu, Jun Si, XinLian Liu, Hui Cao, Cui Jia, YiJun Zeng, LuShun ZhangBio-Technology, B26043-1g) was dissolved in PBS, S (MCE, HY-N0131) in acetone, and Pifithrin-α (PFT-α) (MCE, HY-15484) and Ferrostatin-1 (Fer-1) (MCE, HY-100579) in dimethyl sulfoxide (DMSO). Corresponding solvent control groups

(2) Sec8: a novel positive regulator of RIG-I in anti-RNA viral defenseCell Death & DiseaseJanuary 24, 2026Lin Wang, Wenqing Ma, Peili Hou, Rong Jin, Xinxin Wei, Xingyu Li, Daniel Chang He, Hongmei Wang, Hongbin Heactivates MDA-5 upon transfection; LPS (S1732) specifically activates TLR4 [45–49]. CHX (HY-12320), PFT-α (HY-15484), MG132 (HY-13259), and CQ (HY-17589A) were purchased from MedChemExpress. DMSO (472301) was obtained

(3) Pterostilbene attenuates osteoarthritis progression through p53-dependent autophagy activation: evidence from network analysis and experimental validationFrontiers in PharmacologyJanuary 23, 2026Jiangping Wu, Chunpan Zhang, Yuanyuan Qin, Lixuan Zhu, Lingyan Liu, Fei XuChina). For mechanistic studies involving p53 transcriptional activity, pifithrin-α (PFT-α, 20 μM; HY-15484, MedChemExpress, Shanghai, China), a selective inhibitor of p53-dependent transcription, was added 2

(4) Iron overload-induced ferroptosis in CD8+ T cells leads to functional abnormalities that promote endometriosis progressionBMC MedOctober 27, 2025Shuang Wang, Le Xu, Xue Jiao, Xiaoyu Dong, Zhaoyang Zhong, Qianhui Ren, Xiaoxuan Liu, Ming Yuan, Guoyun Wangdeath. The transcriptional activity of p53 was inhibited by pifithrin-α hydrobromide (PFT-α) PFT-α (HY-15484, MCE, China) was employed to specifically inhibit p53 in wild-type cells [26]. The activation of AhR

(5) NAD+-dependent Sirt6 is a key regulator involved in telomere shortening of in vitro-cultured preimplantation embryosCommun BiolAugust 23, 2025Danjun Li, Wenzhi Li, Xiaoyu Liao, Shutian Jiang, Meng Ma, Zhijie Hu, Kaibo Lin, Weina Yu, Xue Sun, Yong Fan, et al.inhibitor treatment, we prepared solutions of Sirt6 inhibitor (JYQ-42) and Trp53 inhibitor (PTF-α; HY-15484, MedChemExpress) in dimethyl sulfoxide (DMSO). The embryos were subjected to in vitro culture in KSOM

(6) Loss of UBE3A impacts both neuronal and non-neuronal cells in human cerebral organoidsCommun BiolMay 30, 2025R. Chris Estridge, Z. Begum Yagci, Dilara Sen, Tyler J. Johnson, Gautami R. Kelkar, Travis S. Ptacek, Jeremy M. Simon, Albert J. Keung(MedChemExpress, HY-10182A), PF-573228 (MedChemExpress, HY-10461), pifithrin-α hydrobromide (MedChemExpress, HY-15484), Rapamycin (MedChemExpress, HY-10219), SH-42 (MedChemExpress, HY-143228), stattic (MedChemExpress,

(7) Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 DegradationAdvanced ScienceMay 20, 2025Yiwei Lu, Tong Ji, Zhichao Ye, Jianing Yan, Chao Wang, Jiachen Chen, Ziyang Jin, Yongji Zhu, Xiujun Cai, Yifan WangP53 expression, mice received intraperitoneal injections of the P53 inhibitor pifithrin‐α (PFT; MCE, HY‐15484,2.2 mg kg−1, in physiological saline) or control vehicle dimethyl sulfoxide (DMSO; MCE, HY‐Y0320, in

(8) Features and mechanisms of long-lived Myotis somatic fibroblasts in response to DNA replication stressZoological ResearchMay 18, 2025Xiao-Yan Huang, 中国科学院昆明动物研究所, 云南昆明650201, 中国, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650201, China, Xiu-Yun Liu, Wei Wang, Gao-Jing Liu, You-Long Zhu, Xiao Wen, Kai-Qin Li, Bo Zhao, et al.from MCE (Cat. no. HY-100816, USA). Pifithrin-α hydrobromide (PFT-α) was purchased from MCE (Cat. no. HY-15484, USA). The following antibodies were obtained from the indicated suppliers: rat anti- 5-bromo-2'-deoxyuridine

(9) Epstein-Barr virus latent membrane protein 1 subverts IMPDH pathways to drive B-cell oncometabolismPLOS PathogensMay 14, 2025Eric M. Burton, Davide Maestri, Shaowen White, Jin-Hua Liang, Bidisha Mitra, John M. Asara, Benjamin E. Gewurzhyclate (Sigma, D9891-1G, 250 ng/mL), GTP (Roche, 10106399001, 100 μM), Pifithrin-α (MedChemExpress, HY-15484, 10 μM), pan-PKCi staurosporine (Selleckchem, S1421, 100 nM [105]), JNK inhibitor SP 600125 (Apex Bio,

(10) SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicityCell Death DisMarch 31, 2025Xu Yang, Yingjie Guan, George Bayliss, Ting C. Zhao, Shougang Zhuangantibodies UNC0379 (S7570) and Bpv (S8651) were purchased from Selleck Chemicals (Huston, TX, USA). PFA (HY-15484) was purchased from MedChemExpress (Monmouth, NJ, USA). TUNEL kit (11684795910) and CCK-8 assay (96998)

(11) Modulation of TCR stimulation and pifithrin-α improves the genomic safety profile of CRISPR-engineered human T cellsCell Reports MedicineDecember 4, 2024Laurenz T. Ursch, Jule S. Müschen, Julia Ritter, Julia Klermund, Bettina E. Bernard, Saskia Kolb, Linda Warmuth, Geoffroy Andrieux, Gregor Miller, Marina Jiménez-Muñoz, et al.proteins","Chemicals, peptides, and recombinant proteins" ,, cyclic pifithrin-α (hydrobromide),MedChemExpress,Cat#: HY-15484 pifithrin-μ,Calbiochem,Cat#: 506155 Recombinant human IL-2,Peprotech,Cat#: 200-02 Recombinant human IL-7

(12) SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicityResearch SquareAugust 28, 2024Xu Yang, Yingjie Guan, George Bayliss, Ting C. Zhao, Shougang Zhuangantibodies UNC0379 (S7570) and Bpv (S8651) were purchased from Selleck Chemicals (Huston, TX, USA). PFA (HY-15484) was purchased from MedChemExpress (Monmouth, NJ, USA). TUNEL kit (11684795910), and CCK-8 assay (96998)

(13) Aquaporin 1 is renoprotective in septic acute kidney injury by attenuating inflammation, apoptosis and fibrosis through inhibition of P53 expressionFrontiers in ImmunologyAugust 22, 2024Wuyang Lv, Jia Liao, Cuicui Li, Dongyang Liu, Xiaoxiao Luo, RuXue Diao, YuChen Wang, Yingyu JinSciences, Beijing, China). BCA Protein Assay kit (Solarboi life Sciences, Beijing, China). Pifithrin-α (HY-15484), Kevetrin hydrochloride (HY-16271) and Cell Counting Kit-8(CCK8, HY-K0301) assay kit were obtained

(14) Cyclin B2 impairs the p53 signaling in nasopharyngeal carcinomaBMC cancerJanuary 2, 2024Liu Q, Yuan Y, Shang X, Xin L.a 6–8 h transfection in a 5% CO2 incubator at 37°C. The cells were treated with Pifithrin-α (PFTα, HY-15484, MedChemExpress, Monmouth Junction, NJ, USA), an inhibitor of the p53 pathway, at a concentration of

(15) Histone methyltransferase MLL1 drives renal tubular cell apoptosis by p53-dependent repression of E-cadherin during cisplatin-induced acute kidney injuryCell death & diseaseSeptember 6, 2022Zhang C, Guan Y, Zou J, Yang X, Bayliss G, Zhuang S.induced by cisplatin. Materials and methods Reagents and antibodies MM102 (HY-12220A) and PFA (HY-15484) were purchased from MedChemExpress (NJ, USA). Cisplatin was purchased from the Pharmacy of Rhode Island

(16) Pharmacological CDK4/6 inhibition reveals a p53-dependent senescent state with restricted toxicityThe EMBO journalMarch 15, 2022Wang B, Varela-Eirin M, Brandenburg SM, Hernandez-Segura A, van Vliet T, Jongbloed EM, Wilting SM, Ohtani N, Jager A, Demaria M.(MedChemExpress, HY‐10029) was dissolved in DMSO at 10 mM as stock. Pifithrin‐α hydrobromide (MedChemExpress, HY‐15484) was dissolved in DMSO at 10 mM as stock. All the drugs were further diluted in above‐mentioned DMEM

(17) TNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-β1/Smads and activating P53 signaling pathwaysCell Death & DiseaseJanuary 22, 2020Lei Gao et al.from Sigma-Aldrich, Co. (T1512, St. Louis, MO, USA). Pifithrin-α hydrobromide was from MedChemExpress (HY-15484, Monmouth Junction, NJ, USA). Recombinant Human TGF-β1 Protein was from R&D Systems, Inc. (Minneapolis,

(18) JS‑K induces G2/M phase cell cycle arrest and apoptosis in A549 and H460 cells via the p53/p21WAF1/CIP1 and p27KIP1 pathwaysOncology ReportsApril 9, 2019Zeqing Song, Yongxin Yin, Siyuan Hao, Jianmao Wei, Bin Liu, Xiaojie Huang, Chenfeng Gao, Runzhi Zhu, Weiguo Liao, De Caipresent study was <0.1%. Pifithrin‑α (PFT‑α) was purchased from MedChemExpress (New Jersey, USA; cat. no. HY‑15484) and diluted to a final concentration of 30 µM with 100% DMSO. Antibodies against caspase‑3 (cat. no.

(19) Bioinformatics Analysis Identifies p53 as a Candidate Prognostic Biomarker for Neuropathic PainFrontiers in geneticsJanuary 1, 2018Gao Y, Sun N, Wang L, Wu Y, Ma L, Hong J, Ren J, Zhu B, Yu L, Yan M.cages. Intrathecal Injections of Pifithrin-α Intrathecal injections of the p53 inhibitor pifithrin-α (HY-15484; MedChemExpress, United States) were administered as described by Mestre et al. (1994). In short, the

(20) FOXE3 mutations predispose to thoracic aortic aneurysms and dissectionsThe Journal of clinical investigationMarch 1, 2016Kuang SQ, Medina-Martinez O, Guo DC, Gong L, Regalado ES, Reynolds CL, Boileau C, Jondeau G, Prakash SK, Kwartler CS, et al.

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Pifithrin-α hydrobromide from MedChemExpress

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Pifithrin-α hydrobromide from MedChemExpress

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