Devimistat from MedChemExpress

Product Specs
ItemDevimistat
CompanyMedChemExpress
Price $73.00Supplier Page View Company Product Page
Catalog NumberHY-15453
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.59%
TypeChemical
Molecular Weight388.59
FormulaC₂₂H₂₈O₂S₂
Research AreaCancer

Add to Compare List

MedChemExpress

1 Deer Park Drive, Suite F

MONMOUTH JUNCTION, NJ 08852

United States

Phone: US Tel: 609-228-6898
US Fax: 609-228-5909
EU Tel: +4686500910

Email: sales@medchemexpress.com
eu.sales@MedChemExpress.com

Company Profile

Website: medchemexpress.com

(1) ALDH1A3 promotes the lung metastatic organotropism of pancreatic ductal adenocarcinoma through semaphorin signalingiScienceJune 19, 2026Shanshan Shen, Xuetian Qian, Zhao Shi, Yuting Wu, Zitong Zhou, Shuang Nie, Yuanyuan Yu, Siqi Zhou, Kun Liu, Quan Zhou, et al.13778100 Disulfiram,MCE,Cat# HY-B0240 MCI-INI-3,MCE,Cat# HY-169884 Devimistat (CPI-613),MCE,Cat# HY-15453 fetal bovine serum,Biological Industries,Cat# 04-001-1A Geneticin,Thermo Fisher Scientific,Cat# 10131027 Puromycin,Tocris Bioscience

(2) Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell ProfilingCell ProliferationApril 27, 2026Hao Luo, Xiaona Yin, Hongxin He, Yaning Wang, Hongbo ZhangMedChemExpress), Mdivi‐1 (HY‐15886, MedChemExpress), UK‐5099 (HY‐15475, MedChemExpress), devimistat (HY‐15453, MedChemExpress), ammonium tetrathiomolybdate (HY‐W076067, MedChemExpress), 3‐nitropropanoic acid (HY‐W012875,

(3) Metabolic Imbalance Triggers Adaptive Remodeling to Accelerate Diploidization in Murine Haploid Embryonic Stem CellsAdvanced ScienceApril 22, 2026Yi Fu, Wenhao Zhang, Yifan Zhang, Yu He, Yi Du, Yiding Zhao, Chunmeng Yao, Shengyi Sun, Xiaoyan Sheng, Qian Gao, et al.MCE, USA). Inhibitors, including UK5099 (HY‐15475; MCE, USA), 2‐DG (HY‐13966; MCE, USA), devimistat (HY‐15453; MCE, USA), mitoquinone mesylate (HY‐100116A; MCE, USA), emricasan (HY‐10396; MCE, USA), fosfructose

(4) Single‐Mitochondrion ATP Profiling Directs Discovery of Targetable OXPHOS Dependency in CancersAdvanced ScienceFebruary 13, 2026Xu Xiao, Cheng Lu, Hao Chen, Jing Zhou, Yunyun Hu, Haonan Di, Guoqiang Su, Xiaomei Yan(HY‐17471), VLX600 (HY‐12406), BPTES (HY‐12683), C‐968 (HY‐12682), CB‐839 (HY‐11248), and CPI‐613 (HY‐15453) were acquired from MedChemExpress. 5’‐Nucleotides & Nucleosides (K10025A), paraformaldehyde (30525‐89‐4),

(5) A two-strata energy flux system driven by a stress hormone prioritizes cardiac energeticsSignal Transduction and Targeted TherapySeptember 26, 2025Zhiheng Rao, Zhichao Chen, Yuxuan Bao, Zhenzhen Lu, Yuli Tang, Jiamei Zhu, Jianjia Ma, Siyang Dong, Jiawei Shi, Suhui Sheng, et al.palmitate,Sigma-Aldrich,P9767 Atglistatin,MedChemExpress,HY-15859 AICAR,MedChemExpress,HY-13417 L-Leucine,MedChemExpress,HY-N0486 Torin 1,MedChemExpress,HY-13003 Devimistat,MedChemExpress,HY-15453 iFluor 488-Wheat Germ Agglutinin (WGA) Conjugate,Solarbio,I3300 Glucose monohydrate,Sigma-Aldrich,Y0001745 4.

(6) Impaired mitochondrial metabolism is a critical cancer vulnerability for MYC inhibitorsSci AdvJuly 18, 2025William Yang, Qianyu Guo, Songhua Quan, Zachary R. Chalmers, J. Brandon Parker, Mihai Truica, Mary F. Dufficy, Megan M. Kerber, Karthik Vasan, Dikshat G. Gupta, et al.R-GNE-140 (LDHA inhibitor, MedChemExpress, no. HY-100742A), CPI-613 (PDH inhibitor, MedChemExpress, no. HY-15453), and PC-IN-1 (pyruvate carboxylase inhibitor, MedChemExpress, no. HY-142684) were dissolved in DMSO

(7) Acute myeloid leukemia mitochondria hydrolyze ATP to support oxidative metabolism and resist chemotherapySci AdvApril 11, 2025James T. Hagen, McLane M. Montgomery, Raphael T. Aruleba, Brett R. Chrest, Polina Krassovskaia, Thomas D. Green, Emely A. Pacheco, Miki Kassai, Tonya N. Zeczycki, Cameron A. Schmidt, et al.(10 to 1000 nM), CB-839 (5 μM) (MedChemExpress, no. HY-12248), CPI-613 (200 μM) (MedChemExpress, no. HY-15453), or 2-DG (50 mM), where indicated, for 15 min at 37°C. FCCP (10 μM) or alamethicin (0.03 mg/ml) was

(8) Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanomaNat GenetMarch 11, 2025Long Liang, Xinwei Kuang, Yi He, Lin Zhu, Poyee Lau, Xin Li, Dingan Luo, Lan Gong, Wenbin Zhou, Fanglin Zhang, et al.HY-10809), tunicamycin (cat. no. HY-A0098), hygromycin B (cat. no. HY-K1051) and CPI-613 (cat. no. HY-15453) were from MedChemExpress. In vivo anti-mouse CTLA-4 mAb (cat. no. BE0164) and anti-mouse CD8α mAb (cat.

(9) Pyruvate dehydrogenase alleviates macrophage autophagy in Hcy-induced ApoE<sup>–/–</sup> miceActa Biochimica et Biophysica SinicaFebruary 21, 2025Qiujun Liu, Feng Li, Shutong Hu, Ning Ding, Fang Ma, Yinju Hao, Guizhong Li, Jiantuan Xiong, Huiping Zhang, Yideng Jiang(2-DG, HY-13966; MCE, New Jersey, USA), the CPI-613 group was treated with 1.25 μM devimistat (CPI-613, HY-15453; MCE), and the bafilomycin A1 (BafA1, HY-100558; MCE) group was treated with 2.5 μM BafA1 for 24 h. Proteomic

(10) KRAS(G12D)-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDACCell reports. MedicineFebruary 18, 2025Jiang X, Wang T, Zhao B, Sun H, Dong Y, Ma Y, Li Z, Wu Y, Wang K, Guan X, et al.and the solubility of RRx-001, PFK-158 (MCE, #HY-12203), PKM2-IN-1(MCE, #HY-103617), CPI-613 (MCE, #HY-15453), MRTX1133 and PGG, six drug concentrations gradients were set for RRx-001, PFK-158, PKM2-IN-1, CPI-613,

(11) OGDH and Bcl-xL loss causes synthetic lethality in glioblastomaJCI InsightMarch 14, 2024Trang T.T. Nguyen, Consuelo Torrini, Enyuan Shang, Chang Shu, Jeong-Yeon Mun, Qiuqiang Gao, Nelson Humala, Hasan O. Akman, Guoan Zhang, Mike-Andrew Westhoff, et al.treatment. All cells were incubated and maintained at 37°C and 5% CO2. Reagents. CPI-613 (devimistat; HY-15453), navitoclax (ABT-263; HY-10087), A-1210477 (HY-12468), and venetoclax (ABT-199; HY-15531) were purchased

(12) Inhibition of TCA cycle improves the anti-PD-1 immunotherapy efficacy in melanoma cells via ATF3-mediated PD-L1 expression and glycolysisJournal for immunotherapy of cancerSeptember 1, 2023Liu N, Yan M, Tao Q, Wu J, Chen J, Chen X, Peng C.IgG2a (Bio X Cell, USA; #BE0089), PD-1 monoclonal antibody (mAb) (Bio X Cell; #BE0146), CPI613 (MCE, #HY-15453, USA), and PD-1 mAb combined with CPI613 were administered to treat the tumor-bearing mice, and the

(13) Suppression of PFKFB3-driven glycolysis restrains endothelial-to-mesenchymal transition and fibrotic responseSignal transduction and targeted therapySeptember 1, 2022Zeng H, Pan T, Zhan M, Hailiwu R, Liu B, Yang H, Li P.(T8691) were from Sigma-Aldrich (St. Louis, MO, USA). PFK-015 (HY-12204), 3PO (HY-19824), devimistat (HY-15453), dichloroacetate (DCA, HY-Y0445A), galactose (HY-N0210), cycloheximide (HY-12320) were from MedChemExpress

(14) α-Ketoglutarate-Mediated DNA Demethylation Sustains T-Acute Lymphoblastic Leukemia upon TCA Cycle TargetingCancersJune 16, 2022Wang Y, Shen N, Spurlin G, Korm S, Huang S, Anderson NM, Huiting LN, Liu H, Feng H.post-fertilization (dpf). For the drug treatment experiment, fish embryos were treated with vehicle, 2 μM CPI-613 (HY-15453, MCE, NJ, USA), 4 μM Bobcat339 (HY-111558A, MCE), or a combination of 2 μM CPI-613 and 4 μM Bobcat339.

(15) DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancerCommunications biologyNovember 16, 2021Shen N, Korm S, Karantanos T, Li D, Zhang X, Ritou E, Xu H, Lam A, English J, Zong WX, et al.Hs578T cells transduced with pWPI-RFP were injected to fish embryos that were treated with 5 μM CPI-613 (HY-15453, MCE) or vehicle. On day 2 post-transplantation, zebrafish were euthanized and fixed with 4% Paraformaldehyde

(16) Downregulation of ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakiri-mediated apoptosis pathwayVirchows Archiv : an international journal of pathologyMarch 1, 2021Sakuratani T, Takeuchi T, Yasufuku I, Iwata Y, Saigo C, Kito Y, Yoshida K.

(17) Kissing nevus of the penis. Report of two cases and review of the literatureAnais brasileiros de dermatologiaMarch 1, 2014Wang S, Zhou M, Qiao J.

Be the First to Write a Review!

Devimistat from MedChemExpress

Description

MedChemExpress

Citations (17)

Reviews

Devimistat from MedChemExpress

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map