ML355 from MedChemExpress

Product Specs
ItemML355
CompanyMedChemExpress
Price $132.00Supplier Page View Company Product Page
Catalog NumberHY-12341
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity98.11%
TypeChemical
Molecular Weight441.52
FormulaC₂₁H₁₉N₃O₄S₂
Research AreaInflammation/Immunology

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(1) ALOX12 suppresses colon cancer progression by promoting p53-mediated ferroptosis through upregulating ROS-induced stressTranslational Cancer ResearchJuly 31, 2026Junjie Wu, Congxing Liu, Yaya Sun, Guangqing Jiang, Yupeng Zhao, Yihong Zhang, Yiping Yin, Xin Shiliproxstatin-1 (Lip-1, ferroptosis inhibitor) (HY-12726; MCE, Shanghai, China) and ML355 (ALOX12 inhibitor) (HY-12341; MCE, Shanghai, China). All drugs and inhibitors mentioned above were used at different doses depending

(2) Pla2g7 regulates bone homeostasis via Alox12/12-HETE/Gpr31 signaling axisNat CommunDecember 10, 2025Jiayan Jin, Zeyu Zheng, Jiaxuan Gu, Qibin Zhang, Zhikun Xu, Zhenhua Feng, Siyue Tao, Shumin He, Jiao Cheng, Jian Wang, et al.human M-CSF (Cat#11682-HNCH, SinoBiological) and RANKL (Cat#11792-HNAH, SinoBiological). ML355 (Cat#HY-12341) and Darapladib (Cat#HY-10521) were purchased from MedChemExpress. Pla2g7 (Cat#C624, Novoprotein). 12-HETE

(3) 12/15-lipoxygenases mediate toll-like receptor 4-dependent nociplastic pain hypersensitivity in female micePainDecember 1, 2025Cristina Miliano, Irene Chen, Brieann Brown, Laura B. Murdaugh, Yuyang Dong, Kelly A. Eddinger, Shuo Geng, Liwu Li, Tony L. Yaksh, Michael D. Burton, et al.HY-111310, lot# 110818) and 12-LOX-p (ML355, Cayman Catalog # 18537, lot# 0555321–8 or MCE Catalog # HY-12341, lot# 29241) for unlabeled investigational use only were prepared in a vehicle (VEH) of a 1:1 mix of

(4) Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cellsCell Stem CellAugust 1, 2024Jason S. Kirk, Jie Wang, Mark Long, Spencer Rosario, Amanda Tracz, Yibing Ji, Rahul Kumar, Xiaozhuo Liu, Anmbreen Jamroze, Prashant K. Singh, et al.QID, 1x/every 4 days; IP injection; #HY-15147, MCE), ML-355 (30 mg/kg QOD, 3x/week; IP injection; #HY-12341, MCE), Bortezomib (1 mg/kg QD, 1x/week; IV injection; #HY-10227, MCE), Tanzisertib (10 mg/kg QD, 5x/week;

(5) ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escapeCell Death DisDecember 7, 2023Tianyao Liu, Xinyan Xu, Jiazheng Li, Ming Bai, Wenjie Zhu, Yanqing Liu, Siyang Liu, Zihan Zhao, Tianhang Li, Ning Jiang, et al.R)-RSL3 (RSL3, ferroptosis inducer, CSN17581) was obtained from CSNpharm (USA). ML355 (ALOX12 inhibitor, HY-12341) and Zileuton (ALOX5 inhibitor, HY-14164) were purchased from MedChemExpress (MCE, USA). All the above-mentioned

(6) TRPM2 Mediates Hepatic Ischemia–Reperfusion Injury via Ca 2+ -Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 ExpressionResearch (Wash D C)May 31, 2023Cheng Zhong, Jing Yang, Yiyin Zhang, Xiaoxiao Fan, Yang Fan, Ning Hua, Duguang Li, Shengxi Jin, Yirun Li, Peng Chen, et al.plates, respectively. The next day, cells were treated with 10 μM A10 or 5 μM Fer-1, 0.1 μM ML355 (HY-12341; MCE, New Jersey, USA), or 10 μM MCU-i4 (HY-138620; MCE) for 30 min at 37 °C during exposure to 10 μM

(7) An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injuryNature medicineJanuary 1, 2018Zhang XJ, Cheng X, Yan ZZ, Fang J, Wang X, Wang W, Liu ZY, Shen LJ, Zhang P, Wang PX, et al.

(8) First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on HemostasisArteriosclerosis, thrombosis, and vascular biologyOctober 1, 2017Adili R, Tourdot BE, Mast K, Yeung J, Freedman JC, Green A, Luci DK, Jadhav A, Simeonov A, Maloney DJ, et al.

(9) Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenaseJournal of medicinal chemistryJanuary 23, 2014Luci DK, Jameson JB 2nd, Yasgar A, Diaz G, Joshi N, Kantz A, Markham K, Perry S, Kuhn N, Yeung J, et al.

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