Pinometostat from MedChemExpress

Product Specs
ItemPinometostat
CompanyMedChemExpress
Price $87.00Supplier Page View Company Product Page
Catalog NumberHY-15593
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.99%
TypeChemical
Molecular Weight562.71
FormulaC₃₀H₄₂N₈O₃
Research AreaCancer

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(1) Human iPSCs derived from cryopreserved testicular somatic cells enable germline regeneration in childhood cancer survivorsHuman Reproduction OpenJune 3, 2026Tiago Macedo, Claudia De Guidi, Leah Nic Aodha, Nageswara Rao Boggavarapu, Maja Piechocka, Xuan Ye, Francesca Mastropasqua, Victoria Keros, Ulrika Norén Nyström, Per Frisk, et al.until day 14 with 3 μM of the DOT1L inhibitor EPZ-5676 (MedChemExpress, Monmouth Junction, NJ, USA, #HY-15593) and 1 μM of the CREBBP/EP300 inhibitor SGC-CBP30 (MedChemExpress, #HY-15826) to enhance reprogramming

(2) Non-gene-edited neural stem cells reverse neuroinflammation and microbiota dysbiosis in a sprague-dawley rat model of autism spectrum disorderTranslational PsychiatryApril 1, 2026Zhaoming Liu, Caixia Wu, Xianjie Li, Han Wang, Muhammad Majid, Rajesh Basnet, Zhiyuan Li10 µM 616452 (Wuxi AppTec), 2 µM TTNPB (Wuxi AppTec), 0.5 µM SAG (Wuxi AppTec), 2 µM EPZ5676 (MCE, HY-15593), 0.05 µM DZNep (Wuxi AppTec), 1 µM Ruxolitinib (Selleckchem, S1378), 0.5 µM VTP50469 (Selleckchem,

(3) TET2 deficiency increases the competitive advantage of hematopoietic stem and progenitor cells through upregulation of thrombopoietin receptor signalingNat CommunMarch 10, 2025Yitong Yang, Severine Cathelin, Alex C. H. Liu, Amit Subedi, Abdula Maher, Mohsen Hosseini, Dhanoop Manikoth Ayyathan, Robert Vanner, Steven M. Chanper animal. Following four weeks of engraftment, mice were subject to pinometostat (60 mg/kg, MCE #HY-15593) or vehicle (10% DMSO, 40% PEG300, 5% Tween-80, and 45% saline) treatment through subcutaneous injection

(4) Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assaysElifeNovember 11, 2024Jonathan G Van Vranken, Jiaming Li, Julian Mintseris, Ting-Yu Wei, Catherine M Sniezek, Meagan Gadzuk-Shea, Steven P Gygi, Devin K Schweppecompound,Crizotinib,MedChemExpress,HY-50878, Chemical compound,PCI-34051,MedChemExpress,HY-15224, Chemical compound,Pinometostat,MedChemExpress,HY-15593, Chemical compound,SB 525334,MedChemExpress,HY-12043, Chemical compound,IRAK-1–4 Inhibitor I,MedChemExpress,HY-13329, Chemical

(5) CHIR99021 and Brdu Are Critical in Chicken iPSC Reprogramming via Small-Molecule ScreeningGenes (Basel)September 13, 2024Kai Jin, Jing Zhou, Gaoyuan Wu, Zeyu Li, Xilin Zhu, Youchen Liang, Tingting Li, Guohong Chen, Qisheng Zuo, Yingjie Niu, et al.HY-P7331), AM580 (MCE, Monmouth Junction, NJ, USA, HY-10475), and EPZ-5676 (MCE, Monmouth Junction, NJ, USA, HY-15593) for induction (Table 1). 2.5. Quantitative Real-Time Polymerase Chain Reaction RNA was extracted

(6) KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression ProgramsCancer discoveryMarch 1, 2022Yan F, Li J, Milosevic J, Petroni R, Liu S, Shi Z, Yuan S, Reynaga JM, Qi Y, Rico J, et al.MedChemExpress, HY-102060 WM-1119, MedChemExpress, HY-102058 SAHA, Cayman, 10009929 EPZ-5676, MedChemExpress, HY-15593 5-aza, Adooq Bioscience, A10105 Decitabine, Adooq Bioscience, A10292 ORY-1001, Cayman, 19136 SNDX-5613,

(7) Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic geneseLifeOctober 27, 2020Yi D, Nguyen HP, Dinh J, Viscarra JA, Xie Y, Lin F, Zhu M, Dempersmier JM, Wang Y, Sul HS.DNA library Preparation Kit Illumina 15028212 Chemical compound, drug EPZ5676 MedChemExpress HY-15593 Software, algorithm Partek Flow Genomics Suite Partek RRID:SCR_011860 Other Rectal probe Physitemp BAT-12 Additional

(8) DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cellsThe Journal of pharmacology and experimental therapeuticsSeptember 1, 2014Klaus CR, Iwanowicz D, Johnston D, Campbell CA, Smith JJ, Moyer MP, Copeland RA, Olhava EJ, Scott MP, Pollock RM, et al.

(9) Potent inhibition of DOT1L as treatment of MLL-fusion leukemiaBloodAugust 8, 2013Daigle SR, Olhava EJ, Therkelsen CA, Basavapathruni A, Jin L, Boriack-Sjodin PA, Allain CJ, Klaus CR, Raimondi A, Scott MP, et al.

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Pinometostat from MedChemExpress

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Pinometostat from MedChemExpress

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