Centrinone from MedChemExpress

Product Specs
ItemCentrinone
CompanyMedChemExpress
Price $201.00Supplier Page View Company Product Page
Catalog NumberHY-18682
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity98.28%
TypeChemical
Molecular Weight633.65
FormulaC₂₆H₂₅F₂N₇O₆S₂
Research AreaCancer

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(1) Centrosome migration and apical membrane formation during epithelial polarization in MDCK cystsElifeSeptember 8, 2026Po-Kai Wang, Keng-Hui Lin, Tang K Tangcentrosome depletion assay, we pre-treated MDCK WT and p53-KO cells with 300 nM centrinone (LCR-263, HY-18682, MedChemExpress, Monmouth Junction, NJ) (Wong et al., 2015) for 3 days on a petri dish to achieve >80%

(2) Adaptable centriole biogenesis via the intrinsically disordered protein ALMS1Nature CommunicationsJune 30, 2026Kanako Ozaki, Ting-Jui Ben Chang, Wen-Qing Yang, Avital Shulman, Denisse Izquierdo, Wann-Neng Jane, Won-Jing Wang, Tim Stearns, Jens Lüders, T. Tony Yang, et al.was used at 200 nM to inhibit PLK1. MG132 was used at 10 μM to inhibit the proteasome. Centrinone (HY-18682, MCE) was used at 125 nM to inhibit PLK4. Cells in which the endogenous PLK4 was replaced with the PLK4

(3) McIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylationEMBO ReportsFebruary 5, 2026Marina Arbi, Margarita Skamnelou, Lydia Koufoudaki, Vasiliki Bakali, Spyridoula Bournaka, Sihem Zitouni, Stavroula Tsaridou, Ozge Karayel, Catherine G Vasilopoulou, Aikaterini C Tsika, et al.tetracycline-dependent promoter were cultured overnight in the presence of 100 nM centrinone (MedChemExpress, HY-18682) or DMSO (Sigma-Aldrich) as a control. HU-induced centriole amplification assay and transfections U2OS

(4) Aurora A regulates the material property of spindle poles to orchestrate nuclear organization at mitotic exitThe EMBO journalDecember 1, 2025Rajeevan A, Olakkal V, Balakrishnan M, Chakrabarty D, Charon F, Noordermeer D, Kotak S.reagents","Chemicals, enzymes, and other reagents" BSA,HiMedia,Cat# MB083 Centrinone,MedChemExpress,Cat# HY-18682 Clarity Western ECL Substrate,Bio-Rad,Cat# 170-5060 DMEM,HiMedia,Cat# AL007A DMEM,MP Biomedicals,Cat#

(5) Rapid and sustained degradation of the essential centrosome protein CEP192 in live mice using the AID2 systemSci AdvFebruary 28, 2025Valentina C. Sladky, Margaret A. Strong, Daniel Tapias-Gomez, Cayla E. Jewett, Chelsea G. Drown, Phillip M. Scott, Andrew J. HollandμM 5-Ph-IAA. To dilute out centrioles, MEFs were treated with 500 nM centrinone (MedChemExpress, no. HY-18682) for up to 72 hours. Imaging Immunofluorescence: Fresh tissue was embedded in TissueTek O.C.T. compound

(6) Centriolar subdistal appendages promote double‐strand break repair through homologous recombinationEMBO reportsOctober 9, 2023Guillermo Rodríguez‐Real, Andrés Domínguez‐Calvo, Rosario Prados‐Carvajal, Aleix Bayona‐Feliú, Sonia Gomes‐Pereira, Fernando R Balestra, Pablo Huertas(CellDrop FL‐UNLTD). To obtain centriole‐less cells, media was supplemented with 125 nM centrinone (Hy‐18682, MCE) for at least 7 days. In clonogenic survival experiments, cells were exposed to centrinone for

(7) CenFind: a deep-learning pipeline for efficient centriole detection in microscopy datasetsBMC bioinformaticsMarch 28, 2023Bürgy L, Weigert M, Hatzopoulos G, Minder M, Journé A, Rahi SJ, Gönczy P.cells were cultured in DMEM (Thermo Fisher Scientific) with 10 % FBS (Merck). Centrinone (MCE Cat# HY-18682) was used at a final concentration of 250 nM for 48 h. For sample preparation, cells were grown on 15

(8) Defect of IL17 Signaling, but Not Centrinone, Inhibits the Development of Psoriasis and Skin Papilloma in Mouse ModelsBiomedicinesAugust 15, 2022Jin B, Zhang Y, Miller HD, He L, Ge D, Wang AR, You Z.Il17rc-KO mice for 5 consecutive days. On the right side of the back skin, 8 µM of centrinone (cat# HY-18682, MedChemExpress, Monmouth Junction, NJ, USA) dissolved in 200 µL of acetone (VWR) was topically administrated

(9) Chlamydia and HPV induce centrosome amplification in the host cell through additive mechanismsCellular MicrobiologyDecember 1, 2021Kevin Wang, Karissa J. Muñoz, Ming Tan, Christine Sütterlinand HPV+Chlamydia cells were incubated with 125nM of the Plk4 inhibitor centrinone (MedChemExpress HY-18682) in standard growth medium starting at 1 hpi. The experiment was evaluated by immunofluorescence microscopy

(10) Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4Science (New York, N.Y.)June 5, 2015Wong YL, Anzola JV, Davis RL, Yoon M, Motamedi A, Kroll A, Seo CP, Hsia JE, Kim SK, Mitchell JW, et al.

(11) Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congressionCurrent biology : CBJanuary 1, 0001"Wu J, Larreategui-Aparicio A, Lambers MLA, Bodor DL, Klaasen SJ, Tollenaar E, de Ruijter-Villani M, Kops GJPL."which centrosome duplication was inhibited, cells were treated with 250 nM centrinone (MedChemExpress, HY-18682) for 10 days. In the co-immunoprecipitation experiments, HeLa cells overexpressing LIC1 were treated

(12) PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studiesPhotochemistry and photobiologyJanuary 1, 0001"Ndiaye MA, Garvey DR, Chhabra G, Singh CK, Nihal M, Ahmad N."using STR testing through the TRIP lab core. Centrinone was purchased from MedChemExpress (catalog #HY-18682) and CFI-400945 was purchased from Selleckchem (catalog #S7552). RealTime-Glo assay: Initial cell

(13) MicroRNA‑155‑5p inhibits trophoblast cell proliferation and invasion by disrupting centrosomal functionMolecular medicine reportsJanuary 1, 0001"Tsai YC, Kuo TN, Lin RC, Tsai HL, Chao YY, Lee PR, Su PJ, Wang CY."h. To block centrosome amplification, cells were treated with 250 nM Centrinone (LCR-263, cat. no. HY-18682; MedChemExpress) at 37°C for 72 h. To activate p38, cells were treated with 1 µM sodium salicylate (cat.

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Centrinone from MedChemExpress

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Centrinone from MedChemExpress

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