Brequinar from MedChemExpress

Product Specs
ItemBrequinar
CompanyMedChemExpress
Price $92.00Supplier Page View Company Product Page
Catalog NumberHY-108325
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.89%
FormulaC23H15F2NO2
Research AreaInflammation/Immunology; Infection; Cancer
TypeChemical
Molecular Weight375.37
Quantity10 mM * 1 mL
Molecule NameBrequinar

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(1) Lysyl oxidase inhibition disrupts mitochondrial homeostasis to create vulnerability to ferroptosis in TNBCCell Reports MedicineSeptember 15, 2026Ozge Saatci, Burge Ulukan, Metin Cetin, Hellen Kuasne, Constanza Martinez, Elif Percin, Natalia Oleinik, Matthew T. Savoca, Ali Nehme, Aldo Hernández-Corchado, et al.proteins" ,, LXG6403,Cetin et al.28,N/A Leflunomide,MedChemExpress,Cat#HY-B0083 Brequinar,MedChemExpress,Cat#HY-108325 Liproxstatin-1,MedChemExpress,Cat#HY-12726 MG132,MedChemExpress,Cat#HY-13259 DMOG,MedChemExpress,Cat#HY-15893 MLN4924,MedChemExpress,Cat#HY-70062 TAK-981,MedChemExpress,Cat#HY-111789 17-AAG,MedChemExpress,Cat#HY-10211 Tetracycline,Sigma,Cat#T7660 ER-Tracker Blue-White DPX

(2) DHODH inhibition drives albumin-mediated drug resistance through TERF2IP lactylation-activated macropinosome-mitochondria contactNature CommunicationsAugust 14, 2026Junhu Yuan, Tan Wang, Yarui Ma, Guangyu Li, Chenxi Wang, Mei Liu, Zian Cai, Xiaoyue Wang, Xiaobing Wang, Hongying Wang, et al.Dual-Luciferase® Reporter Assay System (E1910, Promega), Leflunomide (HY-B0083, MedChemExpress), Brequinar (HY-108325, MedChemExpress), EIPA (HY-101840, MedChemExpress), IPA3 (HY-15663, MedChemExpress), Gefitinib (HY-50895,

(3) Metabolite glues as a means of purine sensing and chemotherapeutic responseNatureJuly 15, 2026Samuel R. Witus, Megan M. Kober, Heegwang Roh, Zhi Yang, Fouad Choueiry, Avani S. Ghate, Denis V. Titov, Michael Rapé(MedChemExpress, HY-14519), lometrexol (LMX; MedChemExpress, HY-14521), brequinar (MedChemExpress, HY-108325), rapamycin (Adooq Biosciences, A10782), 5-phospho-d-ribose 1-diphosphate (PRPP; Sigma-Aldrich, P8296),

(4) Novel noscapine derivative induces AML differentiation by dual-engaging DHODH and mitochondrial lipids to trigger a metabolic–epigenetic–transcriptional cascadeActa Pharmaceutica Sinica BMay 22, 2026Shuting Shen, Defeng Li, Youping Zhang, Shiwei Li, Lei Li, Wenhao Shen, Yujie Ma, Wenhao Zhang, Rong Tao, Wei Wang, et al.(Sigma‒Aldrich, D7128), Riboflavin phosphate sodium (Sigma‒Aldrich, F2253), Brequinar (MedChemExpress, HY-108325), A-485 (TargetMol, T14073), CTPB (Active Motif, 14065), Decylubiquinone (Cayman, 21027). CD11b-APC

(5) Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic MicroenvironmentAdvanced ScienceApril 3, 2026Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chenwere acquired from Sigma‐Aldrich (St. Louis, MO, USA). Pirfenidone (PFD) (HY‐B0673) and Brequinar (HY‐108325) were purchased from MedChemExpress (New Jersey, USA). Dulbecco's Modified Essential Medium (DMEM) (PM150210),

(6) Integrating network pharmacology, microbiomics, and metabolomics to uncover the therapeutic effect of Liubao tea on osteoarthritisFrontiers in ImmunologyFebruary 19, 2026Guoping Le, Riyou Wen, Zhifa Huang, Huaixi Fang, Jianwei Zheng, Yong Wang, Hanwen LuoTea, Grade 2). Brequinar was acquired from MedChemExpress (MCE, Monmouth Junction, NJ, USA; Cat. No.: HY-108325). 2.2 Animals The animal experiments were approved by the Animal Ethics Committee of Liuzhou Workers’

(7) African swine fever virus hijacks host pyrimidine metabolism to promote viral replicationJournal of VirologyNovember 25, 2025Zebu Song, Yilin Chen, Hui Guo, Guihong Zhang, Lang Gong, Zezhong Zhengand GOT2 (67738-1-Ig; Proteintech). The chemical reagents used were AVN-944 (HY-13560), brequinar (HY-108325), NAC (HY-B0215), V-9302 (HY-112683), AZD-8055 (HY-10422), uridine (HY-B1449), and AOA (HY-107994),

(8) Targeting pancreatic cancer glutamine dependency confers vulnerability to GPX4-dependent ferroptosisCell Reports MedicineFebruary 18, 2025Xuqing Shen, Yueyue Chen, Yingying Tang, Ping Lu, Mingzhu Liu, Tiebo Mao, Yawen Weng, Feier Yu, Yimei Liu, Yujie Tang, et al.(GCH1i),Selleck,Cat# S3688 iFSP1 (FSP1i),MedChemExpress,Cat# HY-136057 Brequinar (DHODHi),MedChemExpress,Cat# HY-108325 z-VAD-FMK (zVAD),Selleck,Cat# S7023 Necrostatin-1 (Nec-1),Selleck,Cat# S8037 Chloroquine (CQ),MedChemExpress,Cat#

(9) Combination decoction of Astragalus mongholicus and Salvia miltiorrhiza mitigates pressure-overload cardiac dysfunction by inhibiting multiple ferroptosis pathwaysFrontiers in PharmacologyDecember 16, 2024Qiyao Xu, Xuan Liu, Zhaoyang Chen, Can Guo, Pengyu Lu, Sujie Zhang, Xindong Wang, Jianping Shen(AngII) (S25704, Yuanye, China), Ferrostatin-1 (Fer-1) (S7243, Selleck, United States), Brequinar (BQR) (HY108325, MedChemExpress), Erastin (Era) (S7242, Selleck, United States), inhibitor of ferroptosis suppressor

(10) Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hubRedox biologyMay 1, 2024Su G, Liu J, Duan C, Fang P, Fang L, Zhou Y, Xiao S.acid (αKG; HY-W013636), CB839 (HY-12248), aspartic acid (Asp; HY-N0666), 6-TG (HY-13765), Brequinar (HY-108325), Aminooxyacetic acid (AOA; HY-107994), glutamic acid (Glu; HY-14608), serine (Ser; HY-N0650), and glycine

(11) 7-Dehydrocholesterol dictates ferroptosis sensitivityNatureFebruary 1, 2024Li Y, Ran Q, Duan Q, Jin J, Wang Y, Yu L, Wang C, Zhu Z, Chen X, Weng L, et al.metabolites including RSL3 (Selleck, S8155), ML210 (MCE, S0788), Erastin (Sigma, E7781), Brequinar (MCE, HY-108325), Ferrostatin-1 (Selleck, S7243), Liproxstatin-1 (Selleck, S7699), AY9944 (APExBIO, A8658), Cariprazine

(12) 17β-oestradiol inhibits ferroptosis in the hippocampus by upregulating DHODH and further improves memory decline after ovariectomyRedox biologyJune 1, 2023Tian Y, Xie Y, Guo Z, Feng P, You Y, Yu Q.ferric ammonium citrate (FAC, 0.5 mg/L, #A9181, Solarbio), Lip-1 (10 μM, S7699, Selleck) and BQR (5 μM, HY- 108325, MCE) for 12 h. Vehicle treatment was used for controls. 2.14 Immunofluorescence staining for cell

(13) Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor–mediated synergistic antileukemic actionsScience AdvancesSeptember 16, 2022Pu Zhang et al.(dinaciclib/gilteritinib); the second cohort: oral gavage of brequinar (25 mg/kg) (MedChemExpress, HY-108325) on days 1 and 4 on a 7-day schedule for a total of six doses, PRT808 at 5 mg/kg formulated in high-fat

(14) Vitamin K1 inhibits ferroptosis and counteracts a detrimental effect of phenprocoumon in experimental acute kidney injuryCellular and molecular life sciences : CMLSJune 28, 2022Kolbrink B, von Samson-Himmelstjerna FA, Messtorff ML, Riebeling T, Nische R, Schmitz J, Bräsen JH, Kunzendorf U, Krautwald S.(SML0583), phenprocoumon (SML2365) and iFSP1 (SML2749) were purchased from Sigma-Aldrich. Brequinar (HY-108325) was purchased from MedChemExpress (via Hölzel Diagnostika, Cologne, Germany). Vitamin K1 (phytomenadione)

(15) Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma TherapyAdvanced science (Weinheim, Baden-Wurttemberg, Germany)June 1, 2022Li B, Chen X, Qiu W, Zhao R, Duan J, Zhang S, Pan Z, Zhao S, Guo Q, Qi Y, et al.Measurements Cooperation). Drug Loading The DHODH inhibitor Brequinar (BQR) was purchased from MCE (HY‐108325) and Selleck (S6626) and used according to the instructions. Fe3O4@SiO2‐NH2 NPs were mixed with BQR

(16) Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2NatureApril 1, 2022Schultz DC, Johnson RM, Ayyanathan K, Miller J, Whig K, Kamalia B, Dittmar M, Weston S, Hammond HL, Dillen C, et al.corn oil (8267, Sigma) and 10% DMSO (2438, Sigma), with dosing twice a day as oral gavage. Brequinar (#HY-108325, MedChemExpress) was resuspended in 10% DMSO and sterile saline, with dosing daily as intraperitoneal injection

(17) Development of accelerated high-throughput antiviral screening systems for emerging orthomyxovirusesAntiviral researchApril 1, 2022Yamaoka S, Weisend CM, Swenson VA, Ebihara H.compounds Antiviral Compound Library (HY-L027), hDHODH-IN-4 (HY-128787; CAS No. 1644156-56-8), brequinar (HY-108325; CAS No. 96187-53-0), and sofosbuvir (HY-15005; CAS No. 1190307-88-0) were purchased from MedChemExpress.

(18) Bifunctional Naphtho[2,3-d][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species ProductionJournal of medicinal chemistryJuly 23, 2020Zuo Z, Liu X, Qian X, Zeng T, Sang N, Liu H, Zhou Y, Tao L, Zhou X, Su N, et al.

(19) Potent antiviral activity of brequinar against the emerging Cantagalo virus in cell cultureInternational journal of antimicrobial agentsNovember 1, 2011Schnellrath LC, Damaso CR.

(20) Characterization of dengue virus resistance to brequinar in cell cultureAntimicrobial agents and chemotherapySeptember 1, 2010Qing M, Zou G, Wang QY, Xu HY, Dong H, Yuan Z, Shi PY.

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Brequinar from MedChemExpress

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Brequinar from MedChemExpress

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