MLi-2 from MedChemExpress

Product Specs
ItemMLi-2
CompanyMedChemExpress
Price $198.00Supplier Page View Company Product Page
Catalog NumberHY-100411
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.80%
TypeChemical
Molecular Weight379.46
FormulaC₂₁H₂₅N₅O₂
Research AreaNeurological Disease

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(1) Targeting leucine-rich repeat kinase 2 overcomes resistance to oncolytic herpes simplex virus-based therapies in glioblastomaNature CommunicationsFebruary 28, 2026Yaning Qin, Zhiqi Liang, Mengqin Yu, Nanqian Lin, Naizhen Wang, Xuanke Huang, Shi Chen, Qun Peng, Yanhua Lin, Heqin Wang, et al.LRRK2-IN-1 (MedChemExpress, HY-10875), DCLK1-IN-1 (MedChemExpress, HY-135985), MLi-2 (MedChemExpress, HY-100411), Fludarabine (MedChemExpress, HY-B0069), PFE-360 (MedChemExpress, HY-120085), BX795 (TopScience, T1830),

(2) Phosphorylation-driven effector switching of Rab7 and Rab12 by the leucine-rich repeat kinase 1 in mast cellsFrontiers in ImmunologyNovember 21, 2025Jana Omar-Kabha, Sewar Omari, Yaara Gorzalczany, Fatima Amer-Sarsour, Elisabeth Kleeblatt, Mitsunori Fukuda, Avraham Ashkenazi, Ronit Sagi-Eisenberg(San Diego, CA, USA). LY333531 (cat #13964) was from Cayman Chemical (Ann Arbor, MI, USA). MLi-2 (cat #HY-100411) was from MedChemExpress (MCE), (Monmouth Junction, NJ, USA). ON-TARGETplus SMARTpool human LRRK1 siRNA

(3) JIP4 and RILPL1 utilize opposing motor force to dynamically regulate lysosomal tubulationJournal of Cell BiologyNovember 3, 2025Luis Bonet-Ponce, Tsion Tegicho, Nuria Fernandez-Martinez, Irene A. Rozenberg, Mia Ashriem, Alexandra Beilina, Jillian H. Kluss, Yan Li, Mark R. CooksonMedChemExpress) was diluted in DMSO and added at 1 mM for the indicated times. MLi-2 (5756; Tocris; and HY-100411; MedChemExpress) was used at 1 μM in DMSO for 90 min prior to LLOME incubation. Nocodazole (M1404; Sigma-Aldrich)

(4) Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone lossCell researchJanuary 1, 2025Fu W, Chen M, Wang K, Chen Y, Cui Y, Xie Y, Lei ZN, Hu W, Sun G, Huang G, et al.(HY-14660, MedChemExpress), 5 nM leucine-rich repeat serine/threonine protein kinase 2 inhibitor (MLi-2) (HY-100411, MedChemExpress), 10 mM GSK-3β inhibitor (LiCl) (7447-41-8, ThermoFisher Scientific) or 10 μM p50 inhibitor

(5) Opposing actions of JIP4 and RILPL1 provide antagonistic motor force to dynamically regulate membrane reformation during lysosomal tubulation/sorting driven by LRRK2bioRxivAugust 28, 2024Luis Bonet-Ponce, Tsion Tegicho, Alexandra Beilina, Jillian H. Kluss, Yan Li, Mark R. Cooksondimethyl sulfoxide (DMSO) and added at 1 mM for the indicated times. MLi-2 (Tocris, 5756; and MedChemExpress, HY-100411) was used at 1 μM in DMSO for 90 min prior to LLOME incubation. Nocodazole (Sigma-Aldrich, M1404) was

(6) High-content phenotyping of Parkinson's disease patient stem cell-derived midbrain dopaminergic neurons using machine learning classificationStem cell reportsOctober 11, 2022Vuidel A, Cousin L, Weykopf B, Haupt S, Hanifehlou Z, Wiest-Daesslé N, Segschneider M, Lee J, Kwon YJ, Peitz M, et al.Compound treatment with 0.1 μM GNE-7915 (MedChemExpress, #HY-18163), 0.1 μM MLi-2 (MedChemExpress, #HY-100411), 0.1 μM PFE-360 (MedChemExpress, #HY-120085), and 0.1 μM rotenone (Sigma, #R8875) was performed at

(7) MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase InhibitionThe Journal of pharmacology and experimental therapeuticsDecember 1, 2015Fell MJ, Mirescu C, Basu K, Cheewatrakoolpong B, DeMong DE, Ellis JM, Hyde LA, Lin Y, Markgraf CG, Mei H, et al.

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MLi-2 from MedChemExpress

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