C29 from MedChemExpress

Product Specs
ItemC29
CompanyMedChemExpress
Price $188.00Supplier Page View Company Product Page
Catalog NumberHY-100461
Research AreaInflammation/Immunology
FormulaC₁₆H₁₅NO₄
Molecular Weight285.29
TypeChemical
Purity98.0%
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Quantity10 mM * 1 mL

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(1) TLR2 mediates cell cycle re-entry and survival of neonatal cardiomyocytes in response to injuryCell Commun SignalAugust 14, 2026Julia Nicke, Adrian Goldspink, Malte Menn, Bernd K. Fleischmann, Mona Malek Mohammadiexperiment, after 24 h of nCM seeding, nCM were treated with TLR2 inhibitor (C29) (100 µM in DMSO, MCE, HY-100461) or without as a control for 1 h. Then, nCM were treated with Pool3 for an additional 48 h. For TLR

(2) 10,11-Dehydrocurvularin attenuates LPS-induced neuroinflammation in BV2 cells by inhibiting the TLR2/MyD88/NLRP3 signaling pathwayBiochem Biophys RepJuly 18, 2026Chenggang Tian, Jian Sun, Jinting Wang, Yu Wang, Peifeng Wan, Guangqiang Sun, Yanling Mu, Meiyu Geng, Baofu Xu, Yu Zhangpharmacological inhibition experiments, cells were pretreated with 100 μg/mL of the TLR2 inhibitor C29 (MCE, HY-100461) or its vehicle for 2 h prior to stimulation with 1 μg/mL LPS alone or in combination with DCV. All

(3) A plant vesicle-dendritic cell chimera for enhancing cancer immunotherapyNature CommunicationsMay 28, 2026Wenzhe Yi, Xindi Qian, Wenlu Yan, Dan Yan, Zhiwen Zhao, Fang Sun, Qi Zhao, Dangge Wang, Yaping Liactivation, CCR2-BMDCs and BMDCs were treated with C29 (50 μM, TLR-2 inhibitor, MedChemExpress, cat.no. HY-100461) and resatorvid (100 nM, TLR-4 inhibitor, MedChemExpress, cat.no. HY-11109) for 4 h at 37°C. Then, CCR2-BMDCs

(4) Multi-omics investigation of perineural invasion in head and neck squamous cell carcinoma: neuroimmune mechanisms and clinical implicationsFront ImmunolMay 12, 2026Muling Deng, Yuhao Lin, Chenyu Fang, Jiaqi Cai, Chuanben Chen, Jianming Dingused to assess cell proliferation. Briefly, FaDu cells treated with DMSO or the TLR2 inhibitor C29(#HY-100461, MCE) were seeded into 24-well plates and incubated with EdU reagent. Cells were then fixed with 4%

(5) ADAR1 regulates dsRNA formation in nuclear and mitochondrial transcripts through editing-dependent and -independent mechanismsCell ReportsMarch 24, 2026Heegwon Shin, Tyler J. Dorrity, Justin Aruda, Kenenni A. Wiegand, Jung Seung Nam, Jiping Yang, Aidan S. Jones, Jake A. Gertie, Meera K. Singh, Yuanjun Yin, et al.,Thermo Fisher Scientific,Cat# 11668019 Actinomycin D,Sigma,Cat# A1410 α-Amanitin,Sigma,Cat# A2263 IMT1,MedChemExpress,Cat# HY-100461 Emricasan,Selleckchem,Cat# S7775 S63845,Selleckchem,Cat# S8383 RNASelect,Thermo Fisher Scientific,Cat#

(6) Lacticaseibacillus paracasei KBL382 contributes to the immunomodulation in THP-1 cellsJournal of MicrobiologyFebruary 28, 2026MinJoong Kim, Min Jung Jo, SungJun Park, Seoung Bum Lee, Sung Jae Jang, Cheonghoon Lee, Woon-Ki Kim, GwangPyo KoL. paracasei KBL382, THP‑1 cells were separately seeded and treated with TLR2 inhibitor C29 (100 μM; HY-100461, MedChemExpress, USA) for 1 h. Subsequently, a total of 4 × 106 CFUs of live or pasteurized L. paracasei

(7) Vaccination with Carbapenemase KPC-2 and Virulence Factor Pal Provided Robust Protection Against Klebsiella pneumoniae Lung InfectionVaccines (Basel)February 19, 2026Shichun Jiang, Yue Yuan, Yuanda Tang, Jingwen Liao, Zhifu Chen, Xiaoqian Yu, Jing Zhu, Qiang Gou, Haiming Jing, Xiaoyu Li, et al.µg/mL). Where indicated, cells were pre-incubated for 1 h with either the TLR2 inhibitor C29 (50 µM; HY-100461, MedChemExpress, Monmouth Junction, NJ, USA) or a TLR2-neutralizing antibody (TL2.1, NB100-56722, Novus Biologicals

(8) A Bioorthogonal and Programmable Bacterial Delivery System for Spatiotemporally Targeted Therapy of Solid TumorsExploration (Beijing)December 18, 2025Yu‐Jia Wang, Wen‐Jie Jiang, Hua‐Jun Zhao, Jian‐Qun Deng, Yi‐Min Cai, Yi Li, Xiao‐Lin Meng, Jin Hou, Feng‐Shan Wang, Ju‐Zheng Shenglipopolysaccharides (LPS, HY‐D1056), hydroxychloroquine sulfate (HY‐B1370), CpG (HY‐146245C), C29 (HY‐100461), TH‐1020 (HY‐116961), H‐151 (HY‐112693), c‐di‐AMP‐disodium (HY‐12326A), NOD‐IN‐1 (HY‐100691), TriDAP

(9) A Bioorthogonal and Programmable Bacterial Delivery System for Spatiotemporally Targeted Therapy of Solid TumorsExploration (Beijing)December 18, 2025Yu‐Jia Wang, Wen‐Jie Jiang, Hua‐Jun Zhao, Jian‐Qun Deng, Yi‐Min Cai, Yi Li, Xiao‐Lin Meng, Jin Hou, Feng‐Shan Wang, Ju‐Zheng Shenglipopolysaccharides (LPS, HY‐D1056), hydroxychloroquine sulfate (HY‐B1370), CpG (HY‐146245C), C29 (HY‐100461), TH‐1020 (HY‐116961), H‐151 (HY‐112693), c‐di‐AMP‐disodium (HY‐12326A), NOD‐IN‐1 (HY‐100691), TriDAP

(10) Lacticaseibacillus rhamnosus LGG Suppresses Osteoclastogenesis via TLR6/NF-κB Modulation and Attenuates Ovariectomy-Induced Bone Loss in MiceProbiotics and Antimicrobial ProteinsSeptember 30, 2025Kangjun Xiong, Jianghua Li, Yaqing Liu, Yang Pan, Yiping Huang, Dongdong Zhan, Lutong Zhang, Ming Tang, Jing Li, Haohao Suntreated with LCM in the presence or absence of the TLR6 inhibitor CU-CPT22 (150 µM, 2 h treatment; Cat#HY-100461; MedChemExpress, USA) prior to endpoint analysis or as specified for particular assays. TRAP Staining When

(11) Calreticulin in the nasal mucus promotes neutrophil migration and pathogen clearanceCell Commun SignalAugust 26, 2025Yichao Ma, Xinming Qin, Shiqi Liu, Ruoyang Lin, Baoyan Meng, Jian Lin, Qian Yanginclude ICAM-1 inhibitor (Cat# HY-100226), TLR2 and TLR4 inhibitor (Cat# HY-116213), TLR2 inhibitor (Cat# HY-100461), and TLR4 inhibitor (Cat# HY-107575). All chemical compounds were dissolved in DMSO and stored at −

(12) Extracellular Vesicles Derived From Streptococcus anginosus Aggravate Lupus Nephritis by Triggering TLR2-MyD88-NF-κB Signalling in NK CellsJ Extracell VesiclesJuly 17, 2025Ying Gong, Lingyue Jin, Lina Duan, Jie Xiao, Yao Li, HongXia Wang, Haifang Wang, Wanying Lin, Yi Zhang, Xiufeng Gan, et al.ELISA kit (Cat: AKR‐5153) was bought from CELL BIOLABS (San Diego, USA). TLR2 inhibitor (C29, Cat: HY‐100461), TLR4 (Stepharine, HY‐N9347), TLR7 (Enpatoran, HY‐134581A), TLR9 (AT791, HY‐124603) and MyD88 inhibitor

(13) Akkermansia muciniphila‐derived hypoacylated rough‐type lipopolysaccharides alleviate diet‐induced obesity via activation of TLR4−IL‐23−IL‐22 immune axisiMetaJuly 17, 2025Li Sun, Yuting Zhang, Wang Dong, Jingzu Sun, Tao Wang, Fei Shao, Huanqin Dai, Junjie Han, Wenzhao Wang, Shuo Wang, et al.seeded into 24‐well plates and preincubated with 10 μM TAK242 (HY‐11109; MedChemExpress), 50 μM C29 (HY‐100461; MedChemExpress), or 25 μM CU‐CPT22 (T15020; TargetMol) for 1 h, respectively. The supernatant was then

(14) Chlorella pyrenoidosa Polysaccharide CPP-3a Promotes M1 Polarization of Macrophages via TLR4/2-MyD88-NF-κB/p38 MAPK Signaling PathwaysMar DrugsJuly 16, 2025Yihua Pi, Qingxia Yuan, Shaoting Qin, Chundie Lan, Qingdong Nong, Chenxia Yun, Haibo Tang, Jing Leng, Jian Xiao, Longyan Zhao, et al.isothiocyanate (FITC)-dextran (Mw 10,000) were obtained from MedChemExpress (Shanghai, China, #HY-11109, #HY-100461, #HY-12031A, #HY-10256, #HY-12041, #HY-18738, #HY-128868, respectively). Human TruStain FcX was purchased

(15) Melanoma-derived versican reactivates tumor-associated macrophages by upregulating pyruvate carboxylase through TLR2-MyD88-RelB axis under normoxiaActa Biochimica et Biophysica SinicaJune 1, 2025Yuxin Shu, Linmin Zhou, Jinqin Qian, Wei-Guo Zhuwere purchased from Beyotime (Shanghai, China). BAY 11-7082 (HY-13453), SR113021 (HY-15870) and C29 (HY-100461) were purchased from MCE (Monmouth Junction, USA). Cell culture 293T and B16 cells were purchased

(16) NETs activate the GAS6-AXL-NLRP3 axis in macrophages to drive morphine toleranceCell Commun SignalApril 11, 2025Qingyan Tian, Haiyue Guo, Mengyao Zhang, Kunmao Jiang, Fan Hu, Yan Xu, Li Wan, Xiaokai Zhou, Yinbing Pan, Wentao Liu, et al.critical in NETs-triggered cytokine production, BMDMs were pretreated with inhibitors of TLR2 (C29, 10 µM, HY-100461, MedChemExpress), TLR4 (TAK242, 10 µM, HY-11109, MedChemExpress), TLR7 (IRS661, 1 µM, GenePharma), TLR8

(17) Mycobacterium tuberculosis specific protein Rv1509 modulates osteoblast and osteoclast differentiation via TLR2 signalingiScienceMarch 21, 2025Liu P, Deng J, Yang Y, Bai W, Dong S, Zhang Z.A103539 Calcein,Chongqing Boer Biotech,Cat#BS41339 RANKL,R&D,Cat# 462-TEC M-CSF,R&D,Cat# 416-ML C29,MedChemexpress,Cat# HY-100461 "Collagenase, Type 2",Diamond,Cat#A004174 0.25%Trypsin,Biosharp,Cat# BL512A Fetal Bovine Serum,Gibco,Cat#10270106 1%

(18) High mortality of Acinetobacter baumannii infection is attributed to macrophage-mediated induction of cytokine storm but preventable by naproxenEBioMedicineOctober 1, 2024Wang H, Xu Q, Heng H, Zhao W, Ni H, Chen K, Wai Chan BK, Tang Y, Xie M, Peng M, et al.culture medium, C29 (100 μM),29 TJ-M2010-5 (20 μM),30 JSH-23 (30 μM),28 and NPXS (30 μM, 60 μM) (MCE, Cat#HY-100461, Cat#HY-139397, Cat#HY-13982, and Cat#HY-15030A) respectively, and then stimulated with Ab (MOI = 5)

(19) TLR2 promotes traumatic deep venous thrombosis of the lower extremity following femoral fracture by activating the NF‑κB/COX‑2 signaling pathway in ratsExperimental and Therapeutic MedicineSeptember 20, 2024Tianting Guo, Lijiao Xiong, Junbin Xie, Jiwei Zeng, Zhihua Huang, Mengting Yao, Xiaoan Zhang, Jianwen Moinjected with an equal volume of physiological saline; the C29 group received 5 mg/kg C29 (cat. no. HY-100461; MedChemExpress) (20) and the Pan3CSK4 group received 1 mg/kg Pam3CSK4 (InvivoGen) (21,22), Based on

(20) Association of IL-9 Cytokines with Hepatic Injury in Echinococcus granulosus InfectionBiomoleculesAugust 14, 2024Tanfang Zhou, Xinlu Xu, Jiang Zhu, Mayire Aizezi, Aili Aierken, Menggen Meng, Rongdong He, Kalibixiati Aimulajiang, Hao Wen(Diprovocim, HY-123942, 500 nM, MCE, Monmouth Junction, NJ, USA) and 2 μL of the TLR2 inhibitor (C29, HY-100461, 50 μM, MCE, Monmouth Junction, NJ, USA). Negative controls (NC) were injected with an equivalent volume

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