Lactic acid from MedChemExpress

Product Specs
ItemLactic acid
CompanyMedChemExpress
Price $50.00Supplier Page View Company Product Page
Catalog NumberHY-B2227
Quantity100 mg
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
TypeChemical
Molecular Weight90.08
FormulaC₃H₆O₃
Research AreaMetabolic Disease; Inflammation/Immunology; Infection; Cancer

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(1) Metabolic-pathway-based classification of tendinopathy reveals a precise therapeutic strategy targeting chondro-modulatory tenocytesBone ResAugust 27, 2026Junchao Luo, Zetao Wang, Ruifu Lin, Jiayun Huang, Chenqi Tang, Honglu Cai, Yang Fei, Dengfeng Ruan, Xinji Wang, Peiru Li, et al.quality. Compounds PX-478 (HY-10231), sodium oxamate (HY-W013032A), temsirolimus (HY-50910), and lactate (HY-B2227) were purchased from MedChemExpress. LOX from Aerococcus viridans (L9795), CAT from bovine liver (SRE0041)

(2) DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated-Acute Kidney InjuryAdv Sci (Weinh)August 17, 2026Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun WangLactylation Assay Recombinant HIS‐histone H3 (Ag10644, Proteintech, China) was incubated with 5 mM lactate (HY‐B2227, MCE, China) and recombinant DDX3x protein (Ag29972, Proteintech, China; 25–100 nM) in reaction buffer

(3) HSPE1 promotes immune evasion in lung adenocarcinoma by mediating mitochondrial oxidative stress via histone lactylation-mediated SDHA transcriptional activationTransl OncolJuly 14, 2026Tao Xie, Manxiang Liplate. After 24 h of culture, the medium was replaced with a fresh one containing 5 mM or 10 mM lactate (HY-B2227, MCE, USA). The cells were collected for subsequent testing after 24 h of cultivation. The cell lines

(4) TRAF6 Lactylation in Glycolytic Macrophages Drives NF-κB Signaling and M1 Polarization During Orthodontic Tooth MovementAdv Sci (Weinh)July 14, 2026Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zhengof 2 g/cm2. Lactate intervention was performed using lactic acid (10 mm in vitro and 500 mm in vivo, HY‐B2227, MCE). The pH of the culture medium was balanced and adjusted in each group by sodium hydroxide (NaOH)

(5) Keratin 18 functions as a lactyltransferase to trigger necroptosis in diabetic kidney disease by modulating Fas transcriptionExperimental & Molecular MedicineJune 12, 2026Qiao Zhao, Xu Liu, Yangliang Yang, Fufen Meng, Zhipeng Meng, Minmin Zhuused to treat the mice in this study. Mice that were intraperitoneally injected with 1 g/kg lactate (HY-B2227; MCE) once a day after the injection of citrate buffer or STZ were assigned to the lactate group (n

(6) Integrating single-cell and bulk transcriptomic analyses to explore key lactylation-related genes in benign prostatic hyperplasiaScientific ReportsMay 25, 2026Xiaotong Pang, Deyong Zheng, Rongbin Zhou, Kun Dong, Fubo Wangtreatment BPH-1 cells were cultured in a medium supplemented with 10 mM or 20 mM exogenous lactate (MCE, HY-B2227) for 48 h to investigate the direct regulatory effects of lactate on IL-6 and IL-8 secretion. Upon completion

(7) G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal TransitionAdvanced ScienceMay 10, 2026Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, et al.2‐deoxy‐D‐glucose (2‐DG, HY‐13966, MedChemExpress, 500 mg/kg, purity: 99.93%, dissolved in PBS), lactate (HY‐B2227, MedChemExpress, 500 mg/kg, purity: 85.12%, dissolved in a mixture of DMSO, PEG300, Tween‐80, and saline),

(8) Inducible secretion of LIGHT by engineered probiotics enables localized cytokine therapy and robust antitumor immunityRSC AdvApril 8, 2026Xinyu Li, Shuaijie Ding, Biao Yang, Yi Wang, Wei XieExperimental section 2.1. Materials EcN was purchased from Baosai Biotech Company. Lactic acid (catalog no. HY-B2227, CAS no. 50-21-5) was purchased from MCE. APC/Cy7 anti-mouse CD45, FITC anti-mouse CD3, PE anti-mouse CD80

(9) PER2 knockdown drives immunotherapy resistance in gastric cancer via metabolic reprogramming of myeloid-derived suppressor cellsCancer & MetabolismApril 2, 2026Shenggang Zhan, Shixi Lu, Feng Xiong, Haitao Li, Wenbiao ChenM-MDSCs at a 1:1 ratio. Experimental groups included the Con group, the lactate-treated group (10 mM; HY-B2227, MedChemExpress, USA), the fatty acid-treated group (20 µM; HY-L182, MedChemExpress, USA), the lactate

(10) Hypoxia‐Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via the Wnt/β‐Catenin PathwayThe Kaohsiung Journal of Medical SciencesApril 1, 2026Xin‐Hua Zhu, Jing‐Wen Hou, Zhong‐Ying Lv, Ming‐Hui Sun, Xiao‐Yang Zhang, Lei Zhang, Mei WangAC16 cells, followed by 24‐h culture under hypoxic conditions [18]; (e) hypoxia + LA group: 15 μM LA (HY‐B2227; MCE) was added to the culture medium of AC16 cells, followed by 24‐h incubation under hypoxic conditions

(11) Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidationRen FailMarch 11, 2026Weili Wang, Yilin Gao, Yizhen Chen, Meng Cheng, Liuting Wei, Yonghao Sang, Lei Zhang, Rong Dai, Yiping Wangidentifies potential therapeutic targets. 2. Material and methods 2.1. Chemicals and reagents Lactate (HY-B2227, purity = 85.12%) and oxamic acid sodium (HY-W013032A, purity = 99.72%) were purchased from MedChemExpress

(12) Lactate induces renal lipid accumulation and aggravates renal fibrosis by inhibiting the PPARα signaling pathway and fatty acid oxidationRen FailMarch 10, 2026Weili Wang, Yilin Gao, Yizhen Chen, Meng Cheng, Liuting Wei, Yonghao Sang, Lei Zhang, Rong Dai, Yiping Wangidentifies potential therapeutic targets. 2. Material and methods 2.1. Chemicals and reagents Lactate (HY-B2227, purity = 85.12%) and oxamic acid sodium (HY-W013032A, purity = 99.72%) were purchased from MedChemExpress

(13) NPM3 functions as a lactyltransferase to promote necroptosis in male diabetic cardiomyopathy mice models via FASN transcription modulationNature CommunicationsMarch 9, 2026Hongjiao Xu, Xinyu Jiang, Fangrui Wang, Fufen Meng, Yue Liu, Jiechun Huang, Jinbao Li, Minmin Zhuincubated with recombinant human His-histone H3 (Ag10644; Proteintech, Wuhan, China) and lactate (5 mM; HY-B2227; MCE, China) in incubation buffer (50 mM HEPES, 25 mM KCl, 2 mM MgCl2, and 4 mM ATP; pH 7.5) for 3 h

(14) The glycolytic enzyme PFKM promotes renal fibrosis by activating the NF-κB pathway via lactate-mediated H3K18 lactylationCellular and Molecular Life SciencesFebruary 19, 2026Yizhen Chen, Weili Wang, Meng Cheng, Liuting Wei, Yonghao Sang, Yilin Gao, Wei Zhang, Lei Zhang, Rong Dai, Yiping Wang(HY-13453, MCE, New Jersey, USA), 2-Deoxy-D-glucose (2-DG) (HY-13966, MCE, New Jersey, USA), or Lactate (HY-B2227, MCE, New Jersey, USA) for 1 h before TGF-β1stumulation. RNA-seq Total RNA was extracted from renal

(15) Targeting mesenchymal monocyte-derived macrophages to enhance the sensitivity of glioblastoma to temozolomide by inhibiting TNF/CELSR2/p65/Kla-HDAC1/EPAS1 axisJournal of advanced researchFebruary 1, 2026Gao W, Long X, Lin X, Deng K, Li D, Huang M, Wang X, Liu Q, Wu M.(https://www.genechem.com.cn/). TREM1 inhibitory peptide GF9 (MCE, HY-P10086) and LP17 (MCE, HY-P3400). Lactate (MCE, HY-B2227). Oxamic acid (MCE; HY-W013032). Cell counting kit-8 (CCK-8; MedChemExpress, HY-K0301). Annexin V-FITC/PI

(16) Hyperglycemia exacerbates osteoarthritis by impairing macrophage efferocytosis through modulation of CD11b lactylationNature CommunicationsDecember 12, 2025Hao Zhou, Yong Xiao, Xinchen Xue, Jiuxiang Liu, Hongtao Xu, Jinwen Wang, Jinchun Zhou, Qiang Zuo, Wenwei Liang, Huanghe Song, et al.effect of lactylation modifications on synovial macrophage efferocytosis, we administered lactate (MCE, HY-B2227) to OA mice via intraperitoneal injection. Following OA induction, mice received weekly intraperitoneal injections

(17) Deoxynivalenol induces ferroptosis via inhibiting glycolysis-H3K18la-STEAP3 axis to promote ovary damage in pigletsCommunications BiologyNovember 20, 2025Shuhao Fan, Ren Zhou, Xiaoshu Xue, Haibo Ye, Qianqian Wang, Jinyu Guan, Fang Tian, Lei Yang, Guangpei Xu, Dalong Ren, et al.containing 5% CO2 and 95% air. Drug treatments 2-DG (MCE; Cat. No. HY-13966), lactate (MCE; Cat. No. HY-B2227), Nala (Macklin; S817880), and melatonin (MCE; Cat. No. HY-B0075) were dissolved in water as per the

(18) AARS1-mediated lactylation of H3K18 and STAT1 promotes ferroptosis in diabetic nephropathyCell Death & DifferentiationSeptember 23, 2025Jia Hong, Hongjiao Xu, Lang Yu, Zhuang Yu, Xiangyuan Chen, Zhipeng Meng, Jiali Zhu, Jinbao Li, Minmin ZhuProteintech, Wuhan, China) or GST-H3 (1 μg, ab159999, Abcam, Cambridge, UK) along with lactate (5 mM; HY-B2227, MCE, China) in incubation buffer (50 mM HEPEs, 25 mM KCl, 2 mM MgCl2, 4 mM ATP, pH 7.5) for 3 h at

(19) Global Lactylome Reveals Lactylation‐Dependent Mechanisms Underlying CXC Motif Chemokine Ligand 12 Expression in Pulmonary Endothelium During Acute Respiratory Distress SyndromeMedComm (2020)August 29, 2025Xu Liu, Haofei Wang, Weijie Ni, Xuecheng Dong, Mingzhu Zheng, Wei Changperitoneal cavity, and the incision was closed with 4‐0 silk. Lactate (pH 6.8, 0.5 g/kg body weight, HY‐B2227, MedChemExpress, USA) was injected intraperitoneally 6 h after procedures in the mouse model. OXA (0.5

(20) ASH2L‐K312‐Lac Stimulates Angiogenesis in Tumors to Expedite the Malignant Progression of Hepatocellular CarcinomaAdvanced ScienceJuly 29, 2025Hexu Han, Shuai Wang, Lixing Ma, Haimeng Yin, Xinxiang Cheng, YiFan Wang, Suqin Xia, Yi Zhang, Yue Zhang, Rong Zhu, et al.(A19571, Abclonal; 1:1000 for western blotting, 5 µg/reaction for co‐IP, RRID:AB_2862675). Lactic acid (HY‐B2227) was obtained from MedChemExpress. To establish a range of concentration and time gradients, lactic

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Lactic acid from MedChemExpress

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Lactic acid from MedChemExpress

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