BAPTA-AM from MedChemExpress

Product Specs
ItemBAPTA-AM
CompanyMedChemExpress
Price $55.00Supplier Page View Company Product Page
Catalog NumberHY-100545
Quantity10 mM * 1 mL
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.68%
TypeChemical
Molecular Weight764.68
FormulaC₃₄H₄₀N₂O₁₈
Research AreaCardiovascular Disease

Add to Compare List

MedChemExpress

1 Deer Park Drive, Suite F

MONMOUTH JUNCTION, NJ 08852

United States

Phone: US Tel: 609-228-6898
US Fax: 609-228-5909
EU Tel: +4686500910

Email: sales@medchemexpress.com
eu.sales@MedChemExpress.com

Company Profile

Website: medchemexpress.com

(1) Pulpal Pressure Aggravates Pulpitis by Mechano-Inflammatory Signal SynergyInternational Dental JournalOctober 1, 2026Weiqi Hu, Hao Cui, Yajing Fu, Xinghong Luo, Lan Li, Zhengyan Wang, Lili Bao, Shengkai Gong, Haotian Luo, Siying Liu, et al.(MCE): Piezo1 agonist Yoda1 (HY-18723), Piezo1 inhibitor GsMTx4 (HY-P1410), Ca²⁺ chelator BAPTA-AM (HY-100545), TRAF6 inhibitor C25-140 (HY-120934), and YAP inhibitor verteporfin (VP; HY-B0146). Stock solutions

(2) TRPV4 drives macrophage pyroptosis via mitochondrial dysfunction and mtROS-dependent NLRP3 inflammasome activation in acute lung injuryRedox BiologySeptember 1, 2026Lan Luo, Xiaofang Yang, Shuyuan Yi, Ziyuan Dong, Kan Wang, Zicheng Zhu, Qian Gao, Jianxue Gao, Yu Jiang, Ming Gong, et al.were pretreated with intracellular calcium chelator BAPTA-AM (BAPTA; 10 μM, 30 min, MedChemExpress, HY-100545, USA), the TRPV4 agonist GSK1016790A (GSK; 300 nM, 30 min, MedChemExpress, HY-19708), the mitochondrial

(3) c-Fos enhances influenza virus replication by stabilizing the M2 protein and promoting autophagosome accumulationJournal of VirologyAugust 18, 2026Xiaonan Chen, Junyang Yan, Mengxue Li, Hanbin Liu, Daiqiang Lu, Yang Wang, Yun Liu, Qiao Zhang, Feng Gao, Jiaojiao Penganti-mouse (E030110-01; EarthOx) secondary antibodies were also employed. Key reagents included BAPTA-AM (HY-100545; MedChemExpress), T-5224 (B4664; APExBIO), cycloheximide (CHX, HY-12320; MedChemExpress), rapamycin

(4) TSPO Regulates TLR4-Mediated Inflammation Through Calcium Homeostasis and Immunometabolic AdaptationInt J Mol SciAugust 17, 2026Xiaoqin Wu, Yaru Zhu, Bo Liu, Xiaoni Liu, Xiangjun ChenmM anhydrous calcium chloride (CaCl2, HY-Y0406E, MCE, Monmouth Junction, NJ, USA) or 20 μM BAPTA-AM (HY-100545, MCE, Monmouth Junction, NJ, USA) was applied to WT and Tspo−/− BV2 cells. For all experiments, non-stimulated

(5) TPI1 Loss Triggers a Metabolite-Driven Mitochondrial Redox Vulnerability via the SARM1-cADPR-Ca2+ AxisAdv Sci (Weinh)July 17, 2026Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, et al.MitoSO Red (S0061S) was purchased from Beyotime. Mito‐TEMPO (HY‐112879), NAC (HY‐B0215), BAPTA‐AM (HY‐100545), EGTA (HY‐D0861), cADPR (HY‐N7395), 8‐Br‐ADPR (HY‐134261) and Rapamycin (HY‐10219) were purchased from

(6) Light-based modulation of astrocytic calcium for regulation of organelle dynamics and morphogenesisJ Cell BiolJuly 6, 2026Lan Yang, Mikael Björklund, Cong Yi, Shue Chen, Zhi Hongobtained from the following sources: rapamycin (HY-10219; MCE), 2-APB (HY-W009724; MCE), BAPTA-AM (HY-100545; MCE), W7 hydrochloride (HY-100912; MCE), SMIFH2 (HY-16931; MCE), EGTA (C17186299; MACKLIN), thapsigargin

(7) VSIG4 suppresses antitumor T cell immunity via the SLC3A2-dependent metabolic-ionic checkpointJ Immunother CancerJune 8, 2026Guoling Huang, Ruirui He, Wei Wang, Heping Wang, Yangyang Li, Bo Zeng, Panyin Shu, Ting Pan, Ming Yi, Lingyun Feng, et al.Beyotime), pH 7.4; for Ca²+ studies, the cells were treated with RPMI 1640 containing BAPTA-AM (Cat# HY-100545, MCE) for 30 min at 37°C. Pretreated Jurkat cells (5×10⁴ cells/well) were seeded into anti-hCD3/CD28

(8) P2RY6+ tumor-associated macrophages as a therapeutic target: suppressing tumor growth and enhancing chemosensitivity in triple-negative breast cancerCell Oncol (Dordr)June 6, 2026Xin Wang, Mingyue Ma, Mingyu Zhang, Han Lu, Ying Liu, Yang Zhou, Bing Han(HY-13104), recombinant human S100A9 (rhS100A9; HY-P70532), U-73122 (HY-13419), 2-APB (HY-W009724), BAPTA-AM (HY-100545), TAK-242 (HY-11109), FPS-ZM1 (HY-19370) and 666-15 (HY-101120) were purchased from MedChemExpress (USA). Bioinformatics

(9) Codonopsis pilosula polysaccharide attenuates the inflammatory response in macrophages induced by Brucella abortus outer membrane protein 19 via regulating ATP2A1 to modulate cell adhesion and calcium signalingFront ImmunolJune 2, 2026Xuxu Wang, Zhiyong Zhou, Nan Zhang, Ziying Zhang, Xingyue Qi, Xingguang Zhang, Zhiguo Gong, Wuzhi Zhong, Kun Liu, Yuan Shenplatform. 2.12 The calcium ion chelator BAPTA-AM Following a 1 h pretreatment with 100 µM BAPTA-AM (MCE, HY-100545, China), mouse peritoneal macrophages were sequentially treated with 50 µg·mL-1 CPPS for 12 h and stimulated

(10) A dual-pronged host-directed therapeutic targeting cyclophilin A and pathogenic interferon response abrogates virus-triggered pregnancy pathologiesNature CommunicationsMay 29, 2026Wenzhe Yu, Hongmin Cao, Zhifang Deng, Jiahao Chen, Beiang Zhang, Shuai Zhu, Dunjin Chen, Xiaoqian Hu, Bin CaoTMN355 (MedChemExpress, # HY-107635), NIM811 (MedChemExpress, #HY-P0025)), BAPTA‑AM (MedChemExpress, #HY-100545), and mPTP-IN-1 (MedChemExpress, #HY-172959) for 48 h. The half-maximal cytotoxic concentration value

(11) Ultrasound-targeted microbubble cavitation enhances anti–PD-L1 therapy in TNBC via eNOS-mediated reoxygenationJCI InsightMay 22, 2026Zhiyu Zhao, Li Ba, Siwei Li, Jianxin Wang, Yuzhou Luo, Sihan Wang, Yan Jin, Changjun Wurole of intracellular Ca2+ in UTMC-induced NO production, cells were pretreated with 50 μM BAPTA-AM (HY-100545, MedChemExpress; an intracellular Ca2+ chelator that buffers cytosolic Ca2+ and prevents Ca2+/calmodulin-dependent

(12) Tanshinone IIA inhibits foam cell formation and alleviates atherosclerosis by regulating the Hedgehog signaling pathway through TRPM2 suppressionScientific ReportsMay 18, 2026Yajuan Yin, Xiaocui Shi, Wenyun Tan, Xiao Zhang, Xiufang Jiang, Mei Liu, Jianan Xu, Da Liu, Le Wang, Mei Wei, et al.treatment. Materials and methods Reagents Tan IIA (Cat# T4952, Sigma, USA); SAG (Cat# HY-12848) and BAPTA-AM (Cat# HY-100545) were obtained from MCE (USA); Oil Red O (ORO) solution (Cat# G1260, Solarbio, China); HE staining kit

(13) Shexiang Tongxin Dropping Pills targeting Piezo1/Ca2+/NLRP3 axis attenuates vascular endothelial inflammationChin MedApril 29, 2026Jingya Liu, Ke Wang, Hongjing You, Liang Long, Yue Xu, Qiuhe Chen, Yang Chen(Sigma-Aldrich, SML1558, USA), Fura-2/AM (F1201, Invitrogen, USA), Lipo8000 (C0533, Beyotime, China), BAPTA-AM (HY-100545, MCE, China). Donkey serum (JAC-017-000-121, Jackson, USA). Antibodies used include: Anti-Piezo1 (DF12083,

(14) Phosphoinositide kinase PIKfyve inhibitor apilimod blocks hepatitis E virus infectioneGastroenterologyMarch 31, 2026Julian J Ring, Sarah Schlienkamp, Maria L Goussain Darido, Xin Zhang, Olinda Pinto Veiga, Jil Alexandra Haase, Emely Richter, André Gömer, Rebecca Menhua Fu, Viet Loan Dao Thi, et al.MedChemExpress (MCE, Monmouth Junction, New Jersey, USA): K11777 (HY-119293), ponesimod (HY-10569), BAPTA-AM (HY-100545), fulvestrant (HY-13636), simvastatin (HY-17502), niclosamide (HY-B0497), raloxifen (HY-13738), verapamil

(15) Piezo1 mediates electrotaxis of alveolar epithelial cells via calcium-dependent PI3K/Akt signalingChinese Journal of TraumatologyMarch 7, 2026Huanyu Luo, Yang Dai, Conghua Lu, Chengjun Shi, Wenyi Liu, Wanda Bi, Juan Du, Li Liindicated. For calcium chelation experiments, cells were pre-treated with 2.5 μM BAPTA-AM (MedChemExpress HY-100545) for 30 min at 37 °C before EF stimulation. BAPTA-AM was maintained in the culture medium during EF

(16) Deficiency of lysosomal TMEM175 in myeloid macrophages exerts anti-tumor immunity via inflammasome and cross-presentation pathwayNature CommunicationsFebruary 14, 2026Ziqi Zhang, Xue li, Tianqi Lu, Jingyun Yang, Xuejiao Han, Zhenfei Bi, Jingwen Luo, Aqu Alu, Weiqi Hong, Siyuan Chen, et al.BAPTA-AM treatment, mice were intratumorally injected with CA-074 (MCE, HY-103350) or BAPTA-AM (MCE, HY-100545) or vehicle (containing 10% DMSO, 40% PEG400, and 50% saline) at a dose of 200 µg/20 g body weight at

(17) Disruption of cellular calcium homeostasis by duck Tembusu virus facilitates viral replication via AMPK pathway activationFrontiers in Cellular and Infection MicrobiologyFebruary 9, 2026Ziding Yu, Xiaoyong Chen, Wenxiao Zhuo, Zhenxing Ma, Zejun Xu, Kuanhui Liu, Julong Wang, Ting Li, Guangshuang Zhu, Benzhong Wang, et al.HY-14656), the AMPK inhibitor Compound C (Cat# HY-13418A), and calcium chelating agent BAPTA-AM (Cat# HY-100545) were purchased from MedChemExpress (Monmouth Junction, NJ, USA). All drugs were dissolved and stored

(18) Lactate-driven ATP6V1B2 lactylation triggers asthmatic inflammation by linking lysosomal dysfunction to mitochondrial ROS-dependent pyroptosisRedox BiologyJanuary 30, 2026Qiaoyun Bai, Ningpo Ding, Rixin Feng, Fengxiang Shang, Zongqi Wang, Liangchang Li, Zhiguang Wang, Yihua Piao, Guangyu Jin, Yilan Song, et al.HY-100350, MCE), BID inhibitor BI-6C9 (Cat# HY-103661, MCE), and calcium chelator BAPTA-AM (10 μM, Cat# HY-100545, MCE). Plasmid transfection was performed using Lipofectamine 3000 (Cat# L3000015, Thermo Scientific);

(19) Intracellular Ca2+ is not essential for SHH signaling but is promoted by Shh ligand in embryonic fibroblastsBMC Molecular and Cell BiologyJanuary 18, 2026Xuanming Shi, Zhaomin Wang, Shupeng Li, Yiming Pan, Bing Shen, Shuzhen Liuat a 1:25 dilution, or with 100 nM SAG for 24 h. To manipulate Ca2+ levels, BAPTA (BAPTA-AM, MCE, #HY-100545) or Ca2+ was added to the culture media in the presence or absence of SHH activators (Shh, ShhN, and

(20) Abnormal mechanical load aggravates subchondral bone remodeling and uneven tibial plateau settlement in knee osteoarthritis via activation of osteoblast Piezo1-Ca²⁺-JAK2/STAT3 signalingInternational Journal of Biological SciencesJanuary 15, 2026Handi Li, Shuo Zhang, Chen Feng, Fangyan Cheng, Yuanyuan Han, Mengxue Wang, Shuai Zhou, Wenbo Shao, Wenzhong Chen, Jingguo Chen, et al.37 °C for 20 min. Cells were then stimulated with 10 μM Yoda1 (MCE, HY-18723), 20 μM BAPTA-AM (MCE, HY-100545), or 5 μM ionomycin (MCE, HY-13434). Fluorescence signals were measured on a flow cytometer (BD FACSCelesta,

Be the First to Write a Review!

BAPTA-AM from MedChemExpress

Description

MedChemExpress

Citations (63)

Reviews

BAPTA-AM from MedChemExpress

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map