Idasanutlin from MedChemExpress

Product Specs
ItemIdasanutlin
CompanyMedChemExpress
Price $95.00Supplier Page View Company Product Page
Catalog NumberHY-15676
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity99.93%
FormulaC31H29Cl2F2N3O4
Research AreaCancer
TypeChemical
Molecular Weight616.48
Quantity10 mM * 1 mL
Molecule NameIdasanutlin

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(1) PROTAC-Mediated Targeted Degradation of MDM2 Induces Tumor-Suppressive Signaling in Osteosarcoma CellsCellsMarch 5, 2026Yeongji Kim, Jin-Woo Kim, Junwon Choi, Jinhyeong Kim, Soyeon Park, Wonji Choi, Hyunju An, Jinman Kim, Minsup Kim, Sujin Choi, et al.No.,Company,Molecule Name,Cat. No.,Solvent 1,Sigma,Nutlin-3,N6287,DMSO 2,MCE,RG7112 (RO5045337),HY-15676,DMSO 3,MCE,Idasanutlin (RG7388),HY-15676,DMSO 4,MCE,Navtemadlin (AMG-232),HY-12296,DMSO 5,MCE,Alrizomadlin

(2) Mutant Isocitrate dehydrogenase 1 sensitizes intrahepatic cholangiocarcinoma cells to MDM2 inhibitorsCancer Research CommunicationsMarch 1, 2026Chien-Tsung Liu, Yung-Yeh Su, Nai-Jung Chiang, Chien-Feng Li, Yu-Chun Ma, Kung-Chao Chang, Yu-Hsuan Hung, Wen-Chun Hung, Li-Tzong ChenMedChemExpress, HY-18767), IDH-305 (MedChemExpress, HY-104036), idasanutlin (synonym: RG7388; MedChemExpress, HY-15676), siremadlin (synonyms: NVP-HDM201; HDM201; MedChemExpress, HY-18658), KDOAM-25 citrate (MedChemExpress,

(3) Mutant Isocitrate Dehydrogenase 1 Sensitizes Intrahepatic Cholangiocarcinoma Cells to MDM2 InhibitorsCancer Res CommunMarch 1, 2026Chien-Tsung Liu, Yung-Yeh Su, Nai-Jung Chiang, Chien-Feng Li, Yu-Chun Ma, Kung-Chao Chang, Yu-Hsuan Hung, Wen-Chun Hung, Li-Tzong ChenMedChemExpress, HY-18767), IDH-305 (MedChemExpress, HY-104036), idasanutlin (synonym: RG7388; MedChemExpress, HY-15676), siremadlin (synonyms: NVP-HDM201; HDM201; MedChemExpress, HY-18658), KDOAM-25 citrate (MedChemExpress,

(4) A triple-action PROTAC for wild-type p53 cancer therapyCell Reports MedicineDecember 16, 2025Gregory H. Bird, Utsarga Adhikary, Michael J. Schmidt, Marina Godes, Bethany Tesar, Christina M. Camara, Joao A. Paulo, Julia F. Vidlak, Thomas M. DeAngelo, Marilyn Marquez, et al.18140-122 (+)-JQ1,MedChemExpress,Cat# HY-13030 (+)-JQ1-carboxylic acid,MedChemExpress,Cat# HY-78695 RG7388,MedChemExpress,Cat# HY-15676 A1874,Selleckchem,Cat# S8785 dBET6,MedChemExpress,Cat# HY-112588 DMSO,Sigma,Cat# D2650-100ML "1M

(5) Deep CRISPR mutagenesis characterizes the functional diversity of TP53 mutationsNat GenetJanuary 7, 2025Julianne S. Funk, Maria Klimovich, Daniel Drangenstein, Ole Pielhoop, Pascal Hunold, Anna Borowek, Maxim Noeparast, Evangelos Pavlakis, Michelle Neumann, Dimitrios-Ilias Balourdas, et al.treated with 10 µM N3a (BOC Sciences, cat. no. B0084-425358), 75 nM RG7388 (MedChemExpress, cat. no. HY-15676), 10 µM RO-5963 (Calbiochem, cat. no. 444153), 1 µM MI-773 (Selleckchem, cat. no. S7649), 750 nM AMG

(6) Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assaysElifeNovember 11, 2024Jonathan G Van Vranken, Jiaming Li, Julian Mintseris, Ting-Yu Wei, Catherine M Sniezek, Meagan Gadzuk-Shea, Steven P Gygi, Devin K Schweppecompound,FTI-277 (hydrochloride),MedChemExpress,HY-15872A, Chemical compound,Idasanutlin,MedChemExpress,HY-15676, Chemical compound,SP600125,MedChemExpress,HY-12041, Chemical compound,PRT062607 (Hydrochloride),MedChemExpress,HY-15323, Chemical

(7) Ubiquitin-specific protease 7 inhibitors reveal a differentiated mechanism of p53-driven anti-cancer activityiScienceMay 17, 2024Alan S. Futran, Tao Lu, Katherine Amberg-Johnson, Jiayi Xu, Xiaoxiao Yang, Saidi He, Sarah Boyce, Jeffrey A. Bell, Robert Pelletier, Takao Suzuki, et al.used to determine cell viability (normalized to untreated control wells). Compounds Idasanutlin (HY-15676) and Venetoclax (HY-15531) were purchased from MedChemExpress. All other chemicals were purchased from

(8) A platform for efficient establishment and drug-response profiling of high-grade serous ovarian cancer organoidsDevelopmental CellJune 19, 2023Wojciech Senkowski, Laura Gall-Mas, Matías Marín Falco, Yilin Li, Kari Lavikka, Mette C. Kriegbaum, Jaana Oikkonen, Daria Bulanova, Elin J. Pietras, Karolin Voßgröne, et al.L8008 Triiodothyronine,Sigma-Aldrich,Cat# T6397 CHIR-99021,MedChemExpress,Cat# HY-10182 Idasanutlin,MedChemExpress,Cat# HY-15676 Formaldehyde,Sigma-Aldrich,Cat# 252549 HistoGel,ThermoFisher,Cat# HG-4000-012 Tissue clear,Sakura,Cat#

(9) LIN28B inhibition sensitizes cells to p53-restoring PPI therapy through unleashed translational suppressionOncogenesisJuly 2, 2022Shi J, Jin X, Wang Y, Zhu T, Zhang D, Li Q, Zhong X, Deng Y, Shen J, Fan X.at 450 nm by a microplate reader (BioTek). Nutlin-3a (HY-10029), Siremadlin (HY-18658), Idasanutlin (HY-15676), and HY-100692 were purchased from MCE MedChemExpress. MI773 (S7649) was purchased from Selleck. Immunohistochemistry Immunohistochemistry

(10) MDM2 inhibitor APG-115 exerts potent antitumor activity and synergizes with standard-of-care agents in preclinical acute myeloid leukemia modelsCell Death DiscoveryJune 1, 2021Douglas D. Fang et al.assays and saline for in vivo studies. RG-7388 (idasanutlin, MDM2-P53 inhibitor, MedChemExpress, Cat# HY-15676) was dissolved in DMSO for in vitro assays. Cell viability assay AML cells were seeded at a density

(11) MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid TumorsCancer ResearchMay 1, 2019Thomas P. Howard et al.In vitro Sensitivity For dose curves, cells were treated for 72 hrs with idasanutlin (MedChemExpress #HY-15676; nine-point half-log curve from 50 μM to 5 nM at 0.5% DMSO) or ATSP-7041 [synthesized as published (24,

(12) MDM2 and MDM4 are Therapeutic Vulnerabilities in Malignant Rhabdoid TumorsCancer Res.February 12, 2019Thomas P. Howard, Taylor E. Arnoff, Melinda R. Song, Andrew O. Giacomelli, Xiaofeng Wang, Andrew L. Hong, Neekesh V. Dharia, Su Wang, Francisca Vazquez, Minh-Tam Pham, et al.In vitro Sensitivity For dose curves, cells were treated for 72 hrs with idasanutlin (MedChemExpress #HY-15676; nine-point half-log curve from 50 μM to 5 nM at 0.5% DMSO) or ATSP-7041 [synthesized as published (24,

(13) Preclinical optimization of MDM2 antagonist scheduling for cancer treatment by using a model-based approachClinical cancer research : an official journal of the American Association for Cancer ResearchJuly 15, 2014Higgins B, Glenn K, Walz A, Tovar C, Filipovic Z, Hussain S, Lee E, Kolinsky K, Tannu S, Adames V, et al.

(14) Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical developmentJournal of medicinal chemistryJuly 25, 2013Ding Q, Zhang Z, Liu JJ, Jiang N, Zhang J, Ross TM, Chu XJ, Bartkovitz D, Podlaski F, Janson C, et al.

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Idasanutlin from MedChemExpress

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Idasanutlin from MedChemExpress

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