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Go 6983
Go 6983 from MedChemExpress
Be the first to write a review!
Citations:
(36)
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MedChemExpress for
Go 6983
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Description
Go 6983 is a pan-PKC inhibitor against for
PKCα
,
PKCβ
,
PKCγ
,
PKCδ
and
PKCζ
with
IC
50
of 7 nM, 7 nM, 6 nM, 10 nM and 60 nM, respectively
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Go 6983
Company
MedChemExpress
Price
$116.00
Supplier Page
View Company Product Page
Catalog Number
HY-13689
Quantity
10 mM * 1 mL
Applications
Bioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Purity
99.32%
Type
Chemical
Molecular Weight
442.51
Formula
C₂₆H₂₆N₄O₃
Research Area
Cancer
Add to Compare List
MedChemExpress
1 Deer Park Drive, Suite F
MONMOUTH JUNCTION
,
NJ
08852
United States
Phone
: US Tel: 609-228-6898
US Fax: 609-228-5909
EU Tel: +4686500910
Email: sales@medchemexpress.com
eu.sales@MedChemExpress.com
Company Profile
Website:
medchemexpress.com
Citations (36)
(1)
An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development
FASEB J
August 29, 2026
Rajnish Kumar, Purbasa Dasgupta, Soma Ray, Soumen Paul
nM
Lunresertib
,"
MedChemExpress
,
HY‐145817A
",
CTB
stage/PKMYT1 inhibitor,1 μM Go6983,"
MedChemExpress
,
HY‐13689
",STB stage/PKC inhibitor,10 μM
PF‐4618433
,"
MedChemExpress
,
HY‐18312
",EVT stage/PYK2
inhibitor
,20 μM
ITX3
,"
MedChemExpress
,
(2)
USP33 alleviates FIS1-dependent mitochondrial fission and cardiac microvascular injury in diabetic cardiomyopathy via deubiquitinating and stabilizing ATG7
Cell Death & Disease
May 30, 2026
Yuqiong Chen, Xiangyu Sun, Xinyan Li, Bo Guan, Xiaopei Yan, Chao Huang, Nannan Zhang, Wenjun Mao, Yuan Tian, Chao Chen,
et al.
cycloheximide (CHX, HY-12320), Rapamycin (
HY-10219
),
Tenilsetam
(
HY-131528
),
JSH-23
(
HY-13982
),
Go 6983
(
HY-13689
),
Tempol
(
HY-100561
) and
ML385
(
HY-100523
were purchased from
MedChemExpress
(USA). Anti-
USP33
antibody
(3)
Palmitoylation-mediated regulation of KAT2A promotes lung metastasis in breast cancer
Nature cell biology
April 1, 2026
Liu M, Vandekeere A, Liu XZ, Schenck S, Fernández-García J, Tricot T, Peng-Winkler Y, Demicco M, Broekaert D, Vermeire I,
et al
.
(
Proteintech
,
HZ-1019
; R&D Systems, 406-ML),
Fedratinib
(
MedChemExpress
,
HY-10409
),
Go 6983
(
MedChemExpress
,
HY-13689
),
STATTIC
(
MedChemExpress
,
HY-13818
), fatty acids: sodium palmitate, stearic acid, oleic acid (Sigma-Aldrich). Generation
(4)
Establishment of Human Formative Pluripotent Stem Cell‐Like Cells Exhibiting Amniotic Differentiation Potentials
Cell Proliferation
March 25, 2026
Xiaoxiao Wang, Qizhi Wang, Yu Wu, Chen Gu, Mingfei Li, Yong Fan, Xiangjin Kang, Lei Li, Zheng Gao, Mingyan Hei,
et al.
propagated in N2B27 with 1 mM PD0325901, 2 mM
XAV939
(
Sigma‐Aldrich
, Cat#
X3004
), 2 mM Gö 6983 (
MCE
, Cat#
HY‐13689
), and 1 × 103 units/mL recombinant human LIF (made in‐house) on irradiated MEF. ROCK inhibitor (Y‐27632)
(5)
GPR43 alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome activation via β-arrestin 2
Biology Direct
January 10, 2026
Changli Wang, Wangzheqi Zhang, Yu Guo, Yan Liao, Na Li, Yan Zhang, Lulong Bo, Jinjun Bian, Jia-feng Wang
experiments. Reagents
4-CMTB
(
HY-P1125
),
Nigericin
(
HY-127019
), Forskolin (
HY-15371
),
YM-254890
(
HY-111557
), and
Go 6983
(
HY-13689
) were purchased from
MedChemExpress
(
MCE
). LPS (437627),
ATP
(
A6559
), MSU (
U2875
), and PTX (
P7208
) were
(6)
Forsythiaside a facilitates autophagy to ameliorate chronic nonbacterial prostatitis in rats by blocking the PKCα/NF-κB pathway
Frontiers in Molecular Biosciences
January 7, 2026
Xingwei Yu, Hongao Tan, Yunqiu Gao, Dandan Qiu, Yan Zhu, Haixin Qi
(C29H36O15, purity ≥99%,
HY-N0028
) and Gö 6983 (specific protein kinase C (PKC)
inhibitor
; purity: 99.32%,
HY-13689
) were purchased from
MedChemExpress
(Monmouth Junction, NJ, USA). Ten percent dimethyl sulfoxide (
20-139
,
(7)
Steroid hormone ouabain cooperates with Na+,K+-ATPase to improve innate immunity against bacterial infections through a non-classic training mechanism regulated by mRNA reprogramming
Acta Pharmaceutica Sinica B
December 29, 2025
Lili Chen, Kuida Chen, RunRun Shan, Jinjun Bian, PeiPei Jin, Hao Lin, Jian Liu, Yan Chen, Siyao Zhu, Fangzhou Yin,
et al.
(HY-P99145),
protein A/G magnetic beads
(
HY-K0202
), streptavidin magnetic beads (
HY-K0208
), Gö 6983 (
HY-13689
),
GSK-3β inhibitor 1
(
HY-126144
), SB203580 (
HY-10256
), BAY11-7082 (
HY-13453
), and erlotinib (
HY-50896
)
(8)
VAPB is a negative regulator of STING-mediated innate immune signaling
Sci Adv
December 5, 2025
Wangsheng Ji, Yin Zhang, Lianfei Zhang, Qingqing Liu, Shengbo Niu, Yuqun Feng, Feilong Chen, Xinqi Liu, Xia Li
Western blotting
) and goat anti-rabbit IgG-HRP (
1:10,000
;
Sigma-Aldrich
,
AP132
,
Western blotting
). Go6983 (
HY-13689
) and
Ruxolitinib
(
HY-50856
) were purchased from
MedChemExpress
.
2′,3′-cGAMP
(tlrl-nacga23) was purchased
(9)
Vitamin D and Retinoic Acid Require Protein Kinase C Activity and Reactive Oxygen Species as Opposing Signals Regulating PEIG-1/GPRC5A Expression in Caco-2 and T84 Colon Carcinoma Cells
Biomolecules
May 13, 2025
Pablo A. Iglesias González, Consuelo Mori, Ángel G. Valdivieso, Tomás A. Santa Coloma
(3-[1-[3-(dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione) (Cat. No.
HY-13689
) were obtained from MedChem Express (
MCE
, Monmouth Junction, NJ, USA). All other reagents were of analytical
(10)
IGF1R Promotes Th17/Treg Cell Development in Experimental Autoimmune Prostatitis
J Inflamm Res
April 30, 2025
Yu Guan, Shaoyu Yue, Yiding Chen, Andong Cheng, Hao Li, Feixiang Yang, Yi Liu, Chaozhao Liang, Jialin Meng
of 10ug/mL, cat.CR39, novoprotein, China), GO6983 (PKC-β
inhibitor
at a concentration of 7 nM, cat.
HY-13689
,
MedChemExpress
, China),
Prostratin
(PKC-β activator at a concentration of 12.5 nM, cat.
HY-107421
,
(11)
IGF1R Promotes Th17/Treg Cell Development in Experimental Autoimmune Prostatitis
Journal of Inflammation Research
April 30, 2025
Yu Guan, Shaoyu Yue, Yiding Chen, Andong Cheng, Hao Li, Feixiang Yang, Yi Liu, Chaozhao Liang, Jialin Meng
of 10ug/mL, cat.CR39, novoprotein, China), GO6983 (PKC-β
inhibitor
at a concentration of 7 nM, cat.
HY-13689
,
MedChemExpress
, China),
Prostratin
(PKC-β activator at a concentration of 12.5 nM, cat.
HY-107421
,
(12)
WNT11 Promotes immune evasion and resistance to Anti-PD-1 therapy in liver metastasis
Nature communications
February 7, 2025
Jiang W, Guan B, Sun H, Mi Y, Cai S, Wan R, Li X, Lian P, Li D, Zhao S.
(CAMKII, 100 nM,
MedChemExpress
, cat. no.
HY-18271
) and
Go 6983
(PKC, 100 nM,
MedChemExpress
, cat. no.
HY-13689
), as indicated in the figures. Cells were harvested at the indicated time points, and protein and RNA
(13)
Challenging the Astral mass analyzer to quantify up to 5,300 proteins per single cell at unseen accuracy to uncover cellular heterogeneity
Nature Methods
January 16, 2025
Julia A. Bubis, Tabiwang N. Arrey, Eugen Damoc, Bernard Delanghe, Jana Slovakova, Theresa M. Sommer, Harunobu Kagawa, Peter Pichler, Nicolas Rivron, Karl Mechtler,
et al.
(
MedChemExpress
,
HY-10254
), 1 µM
XAV-939
(
MedChemExpress
,
HY-15147
), 2 µM Gö 6983 (
MedChemExpress
,
HY-13689
) and 10 ng ml–1
human
leukemia
inhibitory factor (made in-house). Formulation of the N2B27 basal medium
(14)
Downregulation of PIK3IP1/TrIP on T cells is controlled by TCR signal strength, PKC, and metalloprotease-mediated cleavage
The Journal of biological chemistry
December 1, 2024
Murter BM, Robinson SC, Banerjee H, Lau L, Uche UN, Szymczak-Workman AL, Kane LP.
bisindolylmaleimide I
(
Selleckchem
;
S7208
), 10 μM; sotrastaurin (Selleckchem; S279101), 5 μM; Go6983 (
MedChemExpress
;
HY-13689
), 2.5 μM;
Go6976
(
MedChemExpress
;
HY-10183
) 1.25 μM
GW280264X
(Bio-Techne; Cat# 7030), 1 μM; GI254023X
(15)
Platelet Glycoprotein Ibα Cytoplasmic Tail Exacerbates Thrombosis During Bacterial Sepsis
International Journal of Molecular Sciences
October 27, 2024
Yue Xia, Chenglin Sun, Kangxi Zhou, Jie Shen, Jiaojiao Li, Qiuxia Huang, Jiahao Du, Sai Zhang, Kang Sun, Renping Hu,
et al.
PE-conjugated
rat
anti-
mouse
Integrin (
clone
JON/A) came from Emfret Analytics (Eibelstadt, Germany). GO6983 (
HY-13689
) and
Calcein-AM
(
HY-D0041
) were from
MedChemExpress
(Monmouth Junction, NJ, USA). Rabbit antibodies
(16)
ICA1 affects APP processing through the PICK1‐PKCα signaling pathway
CNS Neuroscience & Therapeutics
June 17, 2024
Liangye Ji, ZiJun Meng, Xiangjun Dong, Qunxian Wang, Yanshuang Jiang, Jie Zhang, Dongjie Hu, Shipeng Guo, Weihui Zhou, Weihong Song
and cultured with 90% DMEM and 10% FBS containing 100 μg/mL zeocin. For PKC inhibition, 2 μM
Go 6983
(
HY‐13689
,
MedChemExpress
) or 100 nM aprinocarsen sodium (
HY‐148413
,
MedChemExpress
) were used to treat the 20E2
(17)
Automated, High‐Throughput Phenotypic Screening and Analysis Platform to Study Pre‐ and Post‐Implantation Morphogenesis in Stem Cell‐Derived Embryo‐Like Structures
Advanced Science
January 1, 2024
Vinidhra Shankar, Clemens van Blitterswijk, Erik Vrij, Stefan Giselbrecht
2HCl,ROCK inhibitor,
Enzo life sciences
ALX‐270‐333‐M005
,2 µm Gö 6983,PKC inhibitor,
MedChemExpress
HY‐13689
,2 µm HA‐100 dihydrochloride,PKC inhibitor,SelleckChem S2964,10 µm Indolactam V,PKC activator,
MedChemExpress
(18)
Generating human blastoids modeling blastocyst-stage embryos and implantation
Nature protocols
May 1, 2023
Heidari Khoei H, Javali A, Kagawa H, Sommer TM, Sestini G, David L, Slovakova J, Novatchkova M, Scholte Op Reimer Y, Rivron N.
(MedChemExpress, cat. no.
HY-10254
)
XAV-939
(
MedChemExpress
, cat. no.
HY-15147
) Gö 6983 (
MedChemExpress
, cat. no.
HY-13689
) Human leukemia inhibitory factor (hLIF) (in house) or (
Qkine
, cat. no.
Qk036
) A83-01 (
MedChemExpress
,
(19)
Stiff matrix induced srGAP2 tension gradients control migration direction in triple-negative breast cancer
Theranostics
January 1, 2023
Li C, Zheng Z, Wu X, Xie Q, Liu P, Hu Y, Chen M, Liu L, Zhao W, Chen L,
et al
.
Blebbistatin (
Bleb
) was from Aladdin (Shanghai, China). PMA (PKC activator;
HY-18739
),
Go 6983
(PKC inhibitor;
HY-13689
) and LY-294002 (PI3K inhibitor;
HY-10108
) were obtained from
MedChemExpress
. The following antibodies
(20)
12-O-tetradecanoylphorbol-13-acetate Reduces Activation of Hepatic Stellate Cells by Inhibiting the Hippo Pathway Transcriptional Coactivator YAP
Cells
December 26, 2022
Kim CW, Yoon Y, Kim MY, Baik SK, Ryu H, Park IH, Eom YW.
(4’,6-diamidino-2-phenylindole;
P36930
) was purchased from
Invitrogen
(Waltham, MA, USA), while the pan-PKC inhibitor Gö 6983 (
HY-13689
) was acquired from
MedChemExpress
(Princeton, NJ, USA). All other materials were purchased from Sigma-Aldrich
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Reviews
Be the First to Write a Review!
Go 6983 from MedChemExpress
Supplier Page
View Company Product Page
$116.00
Product Specs
Company Info
Citations
Reviews
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