Description
A non-nucleoside DNMT1 inhibitor (IC50 = 10.3 µM); selective for DNMT1 over DNMT3A and DNMT3B (IC50s = >200 µM), as well as G9a, SUV39H1, MLL1, SET7/9, and PRMT1 (IC50s = >150, >150, >150, >150, and 37.1 µM, respectively); reduces proliferation of HCT116 colon cancer cells from 2.5-10 µM