Description
A TRPM8 antagonist (IC50s = 13 and 20 for the human and rat channels, respectively); selective for TRPM8 over TRPV1, TRPV3, TRPV4, and TRPA1 (IC50s = >20, >20, >20, and >40 µM, respectively), as well as a panel of 100 kinases and 144 additional targets at 1 and 10 µM, respectively; decreases icilin-induced wet-dog shakes in rats from 0.6-3 mg/kg