Description
An inhibitor of FTO (IC50 = 2.6 µM); reduces the proliferation of NB4 and Mono-Mac-6 cells (IC50s = 0.8 and 1.5 µM, respectively); increases m6A levels in isolated human bone marrow cells; suppresses the proliferation of isolated human bone marrow cells and a panel of AML cells (IC50s = 1.9-5.2 µM); delays disease onset and increases survival in a Mono-Mac-6 mouse xenograft model at 2 mg/kg