Description
An inhibitor of the β-catenin-TCF4 protein-protein interaction; inhibits the β-catenin-TCF4 interaction in an immunoprecipitation assay and prevents β-catenin-induced inhibition of SCN5A promoter activity in HEK293 cells at 10 µM; increases levels of Nav1.5 in HL-1 cardiomyocytes; is cytotoxic to GES-1, HGC-27, MKN45, and AGS gastric cancer cells (IC50s = 24.68, 18.2, 489, and 56.76 µM, respectively); decreases PASP and RVHI in a rat model of total pneumonectomy-induced pulmonary hypertension at 25 mg/kg