Description
A potent, selective small molecule Mcl-1 inhibitor that selectively targets the BH3-binding groove of Mcl-1; effectively competes with FITC-MCL-1 SAHBA and FITC-BID BH3 for MCL-1deltaNdeltaC binding with IC50 of 4.7 and 4.8uM, respectively; shows no activity for Bcl-xL; induces caspase activation and leukemia cell death in the specific context of MCL-1 dependence