Description
RU-505 is an effective inhibitor of the Abeta42-fibrinogen interaction with IC50 of 2.72uM in FP assays; restores Abeta-induced altered fibrin clot formation and degradation in vitro and inhibits vessel occlusion in AD transgenic mice, significantly reduces vascular amyloid deposition and microgliosis in the cortex and improves cognitive impairment in mouse models of AD