Description
Relebactam (MK-7655) is a novel beta-lactamase inhibitor that inhibited both class A and C beta-lactamases in vitro; effectively restored imipenem's activity against imipenem-resistant Pseudomonas and Klebsiella strains at clinically achievable concentrations; reduces imipenem MICs for Enterobacteriaceae with KPC carbapenemases from 16-64mg/L to 0.12-1mg/L at a concentration of 4mg/L. Bacterial Infection Phase 3 Clinical