Description
ML324 is a potent, selective JMJD2 demethylase (KDM4) inhibitor with IC50 of 920nM for JMJD2E, shows no activity against LSD1 (>100-fold selectivity); causes depression-like phenotype even in absence of stress exposure, which is associated with an increase in transcriptionally repressive epigenetic marks H3K9me2/me3 in nucleus accumbens (NAc); blocks TNF-alpha-mediated neutrophil adhesion, reduces TNF-alpha-induced ICAM1 protein expression in cerebral microvessels