Description
A potent, selective PKC inhibitor with IC50 of 50nM; displays a high degree of selectivity over PKA (IC50=2.4uM), S6 kinase (IC50=5.0uM) and EGFR (IC50=3.0uM) compared with Staurosporine; inhibits human brain tumors cells (mean IC50=0.4uM), displays antitumor activity in vivo. Blood Cancer Phase 3 Clinical