Description
SGC-iMLLT is the first small molecule chemical probe for the YD of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with Kd of 129 and 77nM respectively, IC50 of 0.26uM (MLLT1); SGC-iMLLT is a potent and selective inhibitor of MLLT1/3-histone interaction; dsiplays excellent selectivity over other human YD proteins (YEATS2/4) and bromodomains