Description
A TAAR1 antagonist (Ki = 0.9 nM for the mouse receptor); selectively inhibits β-phenylethylamine-induced cAMP production in HEK293 cells expressing mouse TAAR1 over human or rat TAAR1 (IC50s = 27.5, 7,487, and 4,539 nM, respectively); reduces p-tyramine-induced decreases in the firing frequency of dopaminergic neurons in mouse VTA slices at 10 nM