Description
A deoxyhypusine synthase inhibitor (Ki = 9.7 nM); inhibits the production of hypusine in CHO cells at 1 µM; inhibits activation of eIF5A2 and enhances the cytotoxicity of doxorubicin in Huh7 and HepG2 cells at 20 µM; reduces tumor growth in a Melan-a Tm5 murine melanoma model at 0.9 mg/kg