Description
An antagonist of MCH1 (Ki = 2.2 nM for the recombinant rat receptor); selective for MHC1 over α1A-adrenergic and dopamine D2 receptors (Kis = 180 and 7,400 nM, respectively, for the recombinant human receptors); increases the time mice spend in the light side of the light/dark exploration test at 20 mg/kg; reduces food intake and body weight, as well as plasma levels of glucose, insulin, and triglycerides, in a mouse model of high-fat diet-induced obesity at 5 mg/kg in combination with rimonabant