Description
PD 90780, a pyrazoloquinazolinone compound, is a nonpeptide inhibitor of NGF binding to p75NTR (IC50 ~ 1 µM in CHO cells), which binds NGF, not p75NTR. Differential activity of PD90780 suggests altered NGF-p75NTR interactions in the presence of TrkA. It may be useful in identifying the region(s) of nerve growth factor involved in binding to the p75 receptor and in clarifying the role of p75 receptor in the actions of the neurotrophins