Description
TPMPA is a selective and competitive GABAA-ρ antagonist with 8-fold selectivity for human recombinant ρ1 receptors over ρ2 receptors. TPMPA exhibits minimal effects on GABAA and GABAB receptors (Kb = 2.1 µM (antagonist), 320 µM (antagonist) and EC50 ~ 500 µM (weak agonist) for GABAA-ρ, GABAA and GABAB receptors, respectively)