Description
STOCK2S 26016 is a cell-permeable lysine deficient protein kinase (WNK) signaling inhibitor (IC50 = 16 µM). STOCK2S 26016 inhibits the binding of WNK1 and WNK4 to SPAK and phosphorylation of downstream transporters, NKCC1 and NCC, in mouse vascular smooth muscle and distal convoluted tubule cell cultures exposed to hypotonic shock, respectively