Description
A BMI1 inhibitor; inhibits proliferation of MOLM-13 AML and Rec-1 MCL cancer cells (IC50s = 22.4 and 136 nM, respectively); induces BMI1 degradation in, and apoptosis of, the same cells; reduces microtubule polymerization and induces cell cycle arrest at the G2/M phase in MM.1S multiple myeloma cells; decreases the number of side population cells in Rec-1 cells (IC50 = 138 nM); increases survival in a MOLM-13 mouse xenograft model at 5 mg/kg, p.o