Description
A triterpenoid with diverse biological activities; inhibits HK2 (IC50 = 5.01 µM); reduces glucose uptake and lactate production in SK-BR-3 breast cancer cells; inhibits IL-1β-induced cPLA2 activation and PGE2 production in, and inhibits the proliferation of, A549 lung cancer cells; decreases tumor growth in an NCI H23 lung cancer mouse xenograft model at 30 and 60 mg/kg; prevents increases in serum urea and creatinine levels in a mouse model of renal ischemia-reperfusion injury at 10 and 20 mg/kg