Description
An inhibitor of STK33 (IC50 = 14 nM); has 700- and 550-fold selectivity for STK33 over PKA and Aurora B kinase, respectively; selective over 81 other kinases in a panel at a concentration of 1 µM; inhibits FLT3 and VEGFR2/KDR by greater than 25% at a concentration of 1 µM; does not decrease viability of KRAS-dependent or KRAS-independent cell lines