Description
A xanthine derivative and neuroprotective agent; increases NGF production in primary mouse astroglia maximally at 1.11 mM; reduces Aβ42-induced cell death in primary rat hippocampal neurons at 20 µg/ml; reduces infarct volume in a rat model of ischemic brain damage induced by permanent MCAO when administered following MCAO as an i.v. infusion at 0.01, 0.05, and 0.1 mg/kg per minute; inhibits cAMP phosphodiesterases, is an antagonist of adenosine A1 and A2 receptors, and binds to adenosine transporters