Description
A furanocoumarin with diverse biological activities; scavenges DPPH and ABTS radicals (EC50s = 19.48 and 10.93 µM, respectively); reduces PMA-induced NETosis in DMSO-differentiated HL-60 neutrophil-like cells 10 nM; decreases HSV-1-induced cytopathic effect in Vero cells at 15.62 and 31.25 µg/ml; decreases Mcl-1 protein levels and increases mitochondrial membrane depolarization and apoptosis in R-HepG2 cells, an effect that can be reversed by overexpression of Mcl-1; inhibits LPS-induced increases in p38 MAPK, JNK, and IκBα phosphorylation, TNF-α, IL-6, and IL-1β protein levels, and nuclear localization of NF-κB p65 in RAW 264.7 macrophages; reduces tumor growth in an R-HepG2 liver cancer mouse xenograft model at 50 mg/kg