Description
A broad-spectrum glutamatergic antagonist; inhibits electrically stimulated synaptic transmission in rabbit hippocampal slices at 2.5 mM; depresses NMDA-, L-homocysteate-, or kainate-induced depolarizations in isolated frog spinal cord at 1 mM; inhibits ibotenate-, quisqualate-, L-glutamate-, and L-aspartate-induced inositol accumulation in rat hippocampal slices at 0.2 mM