Description
A bacterial metabolite; an inhibitor of V-ATPases (Ki = 20 nM in N. crassa vacuolar membranes) and is selective for V-ATPases over P-type ATPases (Ki = 20,000 nM for the E. coli enzyme); induces autophagosome accumulation in MCF-7 cells from 10-1,000 nM; reduces viral genome copy numbers in the culture supernatant of Vero E6 cells infected with H1N1 influenza A