Description
A piperidine nitroxide and spin label with SOD mimetic activity; inhibits lipid peroxidation in rat liver microsomes (IP50s = 117, 61, and 381 µM for peroxidation induced by iron plus NADPH, iron plus ascorbate, and t-butylhydroperoxide, respectively); inhibits production of superoxide anions by 92% via a xanthine-xanthine oxidase reaction in vitro at 1 mM; reduces mean arterial pressure and heart rate in spontaneously hypertensive rats (ED50s = 70 and 63 µmol/kg, respectively) when administered intravenously; a cell-permeable spin label that has been used to quantify intracellular oxygen in various cell types by ESR