Description
An Mcl-1 inhibitor (Ki = 0.19 nM); induces cell death in multiple myeloma, leukemia, and lymphoma cell lines (IC50s = via mitochondrial apoptosis; acts synergistically with trametinib, lapatinib, PLX4032, and erlotinib to reduce proliferation of SK-MEL-2, BT474, A2058, and PC9 cells, respectively; reduces tumor volume in a MV4-11 acute myeloid leukemia mouse xenograft model in a dose-dependent manner