Description
A dual angiotensin II receptor antagonist and neprilysin inhibitor; a combination of the nonpeptide angiotensin II receptor antagonist valsartan and AHU377, a prodrug of LBQ657, which is an inhibitor of the zinc metallopeptidase neprilysin; induces a dose-dependent decrease in mean arterial pressure in a rat double-transgenic model for angiotensin II-dependent hypertension