Description
A p38α MAP kinase inhibitor (IC50 = 13 nM); inhibits TNF-α production in PBMCs (IC50 = 50 nM); reduces LPS-induced TNF-α production up to 89% in mice at 5 mg/kg; reduces paw swelling in a rat adjuvant arthritis model when administered once per day (1, 10, or 100 mg/kg) or twice per day (1 or 5 mg/kg)